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B9DW16

- SYL_STRU0

UniProt

B9DW16 - SYL_STRU0

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei613 – 6131ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSUBE218495:GJ7D-1765-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SUB1729
OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)
Taxonomic identifieri218495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000449: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Leucine--tRNA ligasePRO_1000199230Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218495.SUB1729.

Structurei

3D structure databases

ProteinModelPortaliB9DW16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi610 – 6145"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9DW16 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTFYNHKEIE PKWQDFWAKN HTFKTGTDSS KPKFYALDMF PYPSGAGLHV
60 70 80 90 100
GHPEGYTATD ILSRFKRAQG YNVLHPMGWD AFGLPAEQYA MDTGNDPADF
110 120 130 140 150
TAENIANFKR QINSLGFSYD WDREVNTTDP NYYKWTQWIF TKLYEKGLAY
160 170 180 190 200
EAEVPVNWVE ELGTAIANEE VLPDGTSERG GYPVVRKPMR QWMLKITAYA
210 220 230 240 250
ERLLEDLEEV DWPESIKDMQ RNWIGKSVGA NITFNVKDSE ESFTVFTTRP
260 270 280 290 300
DTLFGATYAV LAPEHALVDA ITTEEQAEAI AEYKRQASLK SDLARTDLAK
310 320 330 340 350
EKTGVWTGAY AINPVNGKEM PIWIADYVLS SYGTGAIMAV PAHDERDWEF
360 370 380 390 400
AKQFHLDIIP VLEGGNVQEA AYTEDGLHIN SDFLDGLNKE EAIAKTVAWL
410 420 430 440 450
EEKEVGNEKV SYRLRDWLFS RQRYWGEPIP IIHWEDGTST AVPEDQLPLI
460 470 480 490 500
LPVTKDIHPS GTGESPLANI TDWLEVTRED GVKGRRETNT MPQWAGSSWY
510 520 530 540 550
YLRYIDPKND KAIADPDLLK QWLPVDIYVG GAEHAVLHLL YARFWHKVLY
560 570 580 590 600
DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVATDKVEK REGSYFHIET
610 620 630 640 650
GEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS
660 670 680 690 700
EEGLEGSRKF LDRVYRLITT KEMTGDNSGA LDKVYHETVK AVTEQIESMK
710 720 730 740 750
FNTAIAQLMI FVNAANKEDK LYKEQAKGFV QLIAPFAPHL GEELWQVLTD
760 770 780 790 800
SNQSISHVAW PTWDENKLVE NDVEIVVQIK GKVKAKLVLA KDLSKEELEA
810 820 830
AALSHEKIQA EIAGKEIVKV IAVPNKLVNI VVK
Length:833
Mass (Da):94,401
Last modified:March 24, 2009 - v1
Checksum:i4D1D1C7B10460FC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM946015 Genomic DNA. Translation: CAR43674.1.
RefSeqiWP_015912021.1. NC_012004.1.
YP_002563002.1. NC_012004.1.

Genome annotation databases

EnsemblBacteriaiCAR43674; CAR43674; SUB1729.
GeneIDi7392057.
KEGGisub:SUB1729.
PATRICi19809169. VBIStrUbe20775_1687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM946015 Genomic DNA. Translation: CAR43674.1 .
RefSeqi WP_015912021.1. NC_012004.1.
YP_002563002.1. NC_012004.1.

3D structure databases

ProteinModelPortali B9DW16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218495.SUB1729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR43674 ; CAR43674 ; SUB1729 .
GeneIDi 7392057.
KEGGi sub:SUB1729.
PATRICi 19809169. VBIStrUbe20775_1687.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SUBE218495:GJ7D-1765-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-854 / 0140J.

Entry informationi

Entry nameiSYL_STRU0
AccessioniPrimary (citable) accession number: B9DW16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3