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B9DW16

- SYL_STRU0

UniProt

B9DW16 - SYL_STRU0

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Protein

Leucine--tRNA ligase

Gene
leuS, SUB1729
Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei613 – 6131ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSUBE218495:GJ7D-1765-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SUB1729
OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)
Taxonomic identifieri218495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000449: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Leucine--tRNA ligaseUniRule annotationPRO_1000199230Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218495.SUB1729.

Structurei

3D structure databases

ProteinModelPortaliB9DW16.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionUniRule annotationAdd
BLAST
Motifi610 – 6145"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9DW16-1 [UniParc]FASTAAdd to Basket

« Hide

MTFYNHKEIE PKWQDFWAKN HTFKTGTDSS KPKFYALDMF PYPSGAGLHV    50
GHPEGYTATD ILSRFKRAQG YNVLHPMGWD AFGLPAEQYA MDTGNDPADF 100
TAENIANFKR QINSLGFSYD WDREVNTTDP NYYKWTQWIF TKLYEKGLAY 150
EAEVPVNWVE ELGTAIANEE VLPDGTSERG GYPVVRKPMR QWMLKITAYA 200
ERLLEDLEEV DWPESIKDMQ RNWIGKSVGA NITFNVKDSE ESFTVFTTRP 250
DTLFGATYAV LAPEHALVDA ITTEEQAEAI AEYKRQASLK SDLARTDLAK 300
EKTGVWTGAY AINPVNGKEM PIWIADYVLS SYGTGAIMAV PAHDERDWEF 350
AKQFHLDIIP VLEGGNVQEA AYTEDGLHIN SDFLDGLNKE EAIAKTVAWL 400
EEKEVGNEKV SYRLRDWLFS RQRYWGEPIP IIHWEDGTST AVPEDQLPLI 450
LPVTKDIHPS GTGESPLANI TDWLEVTRED GVKGRRETNT MPQWAGSSWY 500
YLRYIDPKND KAIADPDLLK QWLPVDIYVG GAEHAVLHLL YARFWHKVLY 550
DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVATDKVEK REGSYFHIET 600
GEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS 650
EEGLEGSRKF LDRVYRLITT KEMTGDNSGA LDKVYHETVK AVTEQIESMK 700
FNTAIAQLMI FVNAANKEDK LYKEQAKGFV QLIAPFAPHL GEELWQVLTD 750
SNQSISHVAW PTWDENKLVE NDVEIVVQIK GKVKAKLVLA KDLSKEELEA 800
AALSHEKIQA EIAGKEIVKV IAVPNKLVNI VVK 833
Length:833
Mass (Da):94,401
Last modified:March 24, 2009 - v1
Checksum:i4D1D1C7B10460FC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM946015 Genomic DNA. Translation: CAR43674.1.
RefSeqiYP_002563002.1. NC_012004.1.

Genome annotation databases

EnsemblBacteriaiCAR43674; CAR43674; SUB1729.
GeneIDi7392057.
KEGGisub:SUB1729.
PATRICi19809169. VBIStrUbe20775_1687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM946015 Genomic DNA. Translation: CAR43674.1 .
RefSeqi YP_002563002.1. NC_012004.1.

3D structure databases

ProteinModelPortali B9DW16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218495.SUB1729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR43674 ; CAR43674 ; SUB1729 .
GeneIDi 7392057.
KEGGi sub:SUB1729.
PATRICi 19809169. VBIStrUbe20775_1687.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SUBE218495:GJ7D-1765-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-854 / 0140J.

Entry informationi

Entry nameiSYL_STRU0
AccessioniPrimary (citable) accession number: B9DW16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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