Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSUBE218495:G1G1Y-1439-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:SUB1418
OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)
Taxonomic identifieri218495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000449 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei53 – 73HelicalUniRule annotationAdd BLAST21
Transmembranei78 – 98HelicalUniRule annotationAdd BLAST21
Transmembranei118 – 138HelicalUniRule annotationAdd BLAST21
Transmembranei143 – 163HelicalUniRule annotationAdd BLAST21
Transmembranei175 – 195HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei226 – 246HelicalUniRule annotationAdd BLAST21
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21
Transmembranei314 – 334HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001172001 – 335Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST335

Interactioni

Protein-protein interaction databases

STRINGi218495.SUB1418

Structurei

3D structure databases

SMRiB9DV75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

B9DV75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTLIAGLI SLLLTALIMP HFIKFYQMKK IGGQQMHEDV KQHLAKAGTP
60 70 80 90 100
TMGGTVFLLV ASFVSFLFAI LFFSHGKSMG LITGILAIVL IYGFIGFLDD
110 120 130 140 150
FLKIFKQINE GLTPIQKLSL QIVGGLIFYF LHVVPSGIDA INVFGFPVHL
160 170 180 190 200
GLLYIFFVLF WVVGFSNAVN LTDGIDGLAS ISVVISLLTY SVIAIHQNQY
210 220 230 240 250
DVLLLCGIMI GALLGFFIFN HKPAKVFMGD VGSLALGAML AAISIALRQE
260 270 280 290 300
WTLLVIGLVY VFETSSVMLQ VSYFKYTKKK FGEGRRIFRM TPFHHHLELG
310 320 330
GLSGKAERWS EWKVDAFLWS VGAVSSLIVL AILYL
Length:335
Mass (Da):37,057
Last modified:March 24, 2009 - v1
Checksum:iB951224237D41A85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM946015 Genomic DNA Translation: CAR43074.1
RefSeqiWP_015911738.1, NC_012004.1

Genome annotation databases

EnsemblBacteriaiCAR43074; CAR43074; SUB1418
GeneIDi24161434
KEGGisub:SUB1418

Similar proteinsi

Entry informationi

Entry nameiMRAY_STRU0
AccessioniPrimary (citable) accession number: B9DV75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health