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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciSUBE218495:GJ7D-1310-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:SUB1276
OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)
Taxonomic identifieri218495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000449 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Exodeoxyribonuclease 7 large subunitPRO_1000200686Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi218495.SUB1276.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiFRKRPNH.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

B9DUT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYLSVSHL TKYLKMKFDR DPYLERVYLT GQVSNFRKRP NHQYFSLKDE
60 70 80 90 100
NAVIQATMWA SAYKRLAFDL EEGMKINVIG RVQIYEPSGS YSIIIEEAVP
110 120 130 140 150
DGIGALAIQF EQLKKKLTNE GFFDDKHKQD LPQFVQKVGV ITSPSGAVIR
160 170 180 190 200
DIITTISRRF PGVEILLFPT KVQGEGAAEE IVANISKANQ REDLDLLIVG
210 220 230 240 250
RGGGSIEDLW AFNEEIVVHA IFASQLPIIS SVGHETDVTL SDFVADRRAA
260 270 280 290 300
TPTAAAELAT PVTKADIISW ISERQNRSYQ ATLRLLHQKR DQVMVLGQSV
310 320 330 340 350
IFRQPERLYD AYLQKIDRLH NSLLNSIKSK LSDSRQAEMT VSHRLQTMNL
360 370 380 390 400
LSTINRYQER LMTLNQWLNV DMQKQFDQLR TRFEKAQDAL LTLDTKRIVA
410 420 430 440
RGYSIVRQED KIISSVKDVS TGDLLAIEMR DGQIEVEVKN GN
Length:442
Mass (Da):50,209
Last modified:March 24, 2009 - v1
Checksum:i5F4262F44517DB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM946015 Genomic DNA. Translation: CAR42780.1.
RefSeqiWP_012658750.1. NC_012004.1.

Genome annotation databases

EnsemblBacteriaiCAR42780; CAR42780; SUB1276.
GeneIDi24161599.
KEGGisub:SUB1276.
PATRICi19808260. VBIStrUbe20775_1246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM946015 Genomic DNA. Translation: CAR42780.1.
RefSeqiWP_012658750.1. NC_012004.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218495.SUB1276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR42780; CAR42780; SUB1276.
GeneIDi24161599.
KEGGisub:SUB1276.
PATRICi19808260. VBIStrUbe20775_1246.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiFRKRPNH.
OrthoDBiEOG64R65J.

Enzyme and pathway databases

BioCyciSUBE218495:GJ7D-1310-MONOMER.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-854 / 0140J.

Entry informationi

Entry nameiEX7L_STRU0
AccessioniPrimary (citable) accession number: B9DUT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: December 9, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.