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B9DUH9

- PYRF_STRU0

UniProt

B9DUH9 - PYRF_STRU0

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei34 – 341SubstrateUniRule annotation
Active sitei63 – 631Proton donorUniRule annotation
Binding sitei117 – 1171SubstrateUniRule annotation
Binding sitei179 – 1791SubstrateUniRule annotation
Binding sitei188 – 1881SubstrateUniRule annotation
Binding sitei208 – 2081Substrate; via amide nitrogenUniRule annotation
Binding sitei209 – 2091SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSUBE218495:GJ7D-1066-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:SUB1025
OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)
Taxonomic identifieri218495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000449: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Orotidine 5'-phosphate decarboxylasePRO_1000164582Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi218495.SUB1025.

Structurei

3D structure databases

ProteinModelPortaliB9DUH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 7010Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9DUH9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MREQRPIIAL DFPDFDTLKD FLNQFPKDEA LYVKIGMELY YAVGPEIVRY
60 70 80 90 100
VKSLGHSVFL DLKLHDIPNT VKSTMKVLAK MGIDMTTVQA AGGVEMLEAA
110 120 130 140 150
REGLGDDPIL IAVTQLTSTS EEQMREDQNI QTTLTESVLH YAKRTALAKL
160 170 180 190 200
DGVVCSAHEV EAIKSVTSKD FLCLTPGIRP KGTDIGDQKR VMTPQEAKAI
210 220 230
GSDFIVVGRP ITQAPDPLAA YHAIKADWNA
Length:230
Mass (Da):25,317
Last modified:March 24, 2009 - v1
Checksum:i9082C5D0CBA32CA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM946015 Genomic DNA. Translation: CAR42289.1.
RefSeqiWP_012658522.1. NC_012004.1.
YP_002562350.1. NC_012004.1.

Genome annotation databases

EnsemblBacteriaiCAR42289; CAR42289; SUB1025.
GeneIDi7392439.
KEGGisub:SUB1025.
PATRICi19807752. VBIStrUbe20775_0993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM946015 Genomic DNA. Translation: CAR42289.1 .
RefSeqi WP_012658522.1. NC_012004.1.
YP_002562350.1. NC_012004.1.

3D structure databases

ProteinModelPortali B9DUH9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218495.SUB1025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR42289 ; CAR42289 ; SUB1025 .
GeneIDi 7392439.
KEGGi sub:SUB1025.
PATRICi 19807752. VBIStrUbe20775_0993.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SUBE218495:GJ7D-1066-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-854 / 0140J.

Entry informationi

Entry nameiPYRF_STRU0
AccessioniPrimary (citable) accession number: B9DUH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3