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B9DSR6

- PUR9_STRU0

UniProt

B9DSR6 - PUR9_STRU0

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciSUBE218495:GJ7D-51-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:SUB0030
    OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)
    Taxonomic identifieri218495 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000449: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Bifunctional purine biosynthesis protein PurHPRO_1000122975Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi218495.SUB0030.

    Structurei

    3D structure databases

    ProteinModelPortaliB9DSR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9DSR6-1 [UniParc]FASTAAdd to Basket

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    MTKRALISVS DKAGIVDFAQ ELKKLGWDII STGGTKTALD TAGIKTIAID    50
    DITGFPEMMD GRVKTLHPNI HGGLLARRDL DTHLKAAQEN GIELIDLVVV 100
    NLYPFKETIL RPDVTYAQAV ENIDIGGPSM LRSAAKNHAS VTVVVDPSDY 150
    ERVLAELTEI GETTYETRQA LAAKVFRHTA AYDALIAEYF TAQVGETKPE 200
    KLTLTYDLKQ EMRYGENPQQ AADFYQKALP TDYSIASAKQ LNGKELSFNN 250
    IRDADAAIRI IRDFKERPTV VALKHMNPCG IGQADTIEKA WDYAYEADSV 300
    SIFGGIVVLN REVDKATAEK MHPIFLEIII APSYSDEALA ILTNKKKNLR 350
    ILQLPFEGQA ASEIEAEYTG VVGGMLVQNQ DVIEEKADAW EVVTERQPSD 400
    DEKEALEFAW RAIKYVKSNG ILIANNHMTL GVGPGQTNRV ASVRIAIEQA 450
    KDRLEGAALA SDAFFPFADN IEEIAAAGIK AIIQPGGSVR DQESIDAANK 500
    HGIAMIFTGV RHFRH 515
    Length:515
    Mass (Da):56,571
    Last modified:March 24, 2009 - v1
    Checksum:i5D4680607974EBC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM946015 Genomic DNA. Translation: CAR40373.1.
    RefSeqiWP_012657600.1. NC_012004.1.
    YP_002561406.1. NC_012004.1.

    Genome annotation databases

    EnsemblBacteriaiCAR40373; CAR40373; SUB0030.
    GeneIDi7392433.
    KEGGisub:SUB0030.
    PATRICi19805754. VBIStrUbe20775_0029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM946015 Genomic DNA. Translation: CAR40373.1 .
    RefSeqi WP_012657600.1. NC_012004.1.
    YP_002561406.1. NC_012004.1.

    3D structure databases

    ProteinModelPortali B9DSR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218495.SUB0030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR40373 ; CAR40373 ; SUB0030 .
    GeneIDi 7392433.
    KEGGi sub:SUB0030.
    PATRICi 19805754. VBIStrUbe20775_0029.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci SUBE218495:GJ7D-51-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-854 / 0140J.

    Entry informationi

    Entry nameiPUR9_STRU0
    AccessioniPrimary (citable) accession number: B9DSR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3