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B9DSR4

- PUR5_STRU0

UniProt

B9DSR4 - PUR5_STRU0

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSUBE218495:GJ7D-49-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:SUB0028
OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)
Taxonomic identifieri218495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000449: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148301Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218495.SUB0028.

Structurei

3D structure databases

ProteinModelPortaliB9DSR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B9DSR4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEKNAYAQS GVDVEAGYEV VERIKKHVAR TERAGVMGAL GGFGGMFDLS
60 70 80 90 100
KTGVKEPVLI SGTDGVGTKL MLAIKYDKHD TIGQDCVAMC VNDIIAAGAE
110 120 130 140 150
PLYFLDYIAT GKNEPAKLEQ VVAGVAEGCV QAGAALIGGE TAEMPGMYGE
160 170 180 190 200
DDYDLAGFAV GIAEKSQIID GSKVSEGDVL LGLASSGIHS NGYSLVRRVF
210 220 230 240 250
ADYEGEAILP ELEGKALKEV LLEPTRIYVK AVLPLVKENL VNGIAHITGG
260 270 280 290 300
GFIENVPRMF SEELAAEIWE EKVPVLPIFK ALETYGEIKH DEMFEIFNMG
310 320 330 340
IGMMLAVKAE NVARVKELLD EPVYEIGRII KKEDKSVIIK
Length:340
Mass (Da):36,577
Last modified:March 24, 2009 - v1
Checksum:iDA2A1C5FA4632DF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM946015 Genomic DNA. Translation: CAR40369.1.
RefSeqiYP_002561404.1. NC_012004.1.

Genome annotation databases

EnsemblBacteriaiCAR40369; CAR40369; SUB0028.
GeneIDi7392429.
KEGGisub:SUB0028.
PATRICi19805750. VBIStrUbe20775_0027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM946015 Genomic DNA. Translation: CAR40369.1 .
RefSeqi YP_002561404.1. NC_012004.1.

3D structure databases

ProteinModelPortali B9DSR4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218495.SUB0028.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR40369 ; CAR40369 ; SUB0028 .
GeneIDi 7392429.
KEGGi sub:SUB0028.
PATRICi 19805750. VBIStrUbe20775_0027.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SUBE218495:GJ7D-49-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-854 / 0140J.

Entry informationi

Entry nameiPUR5_STRU0
AccessioniPrimary (citable) accession number: B9DSR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3