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B9DS83

- FTHS_STRU0

UniProt

B9DS83 - FTHS_STRU0

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSUBE218495:GJ7D-980-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SUB0942
OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)
Taxonomic identifieri218495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000449: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000185267Add
BLAST

Proteomic databases

PRIDEiB9DS83.

Interactioni

Protein-protein interaction databases

STRINGi218495.SUB0942.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9DS83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIEIAQS IALKPITEIV EKVGIAFDDI ELYGKYKAKL SFDKINEVKS
60 70 80 90 100
NPVGKLILVT AINPTPAGEG KSTMSIGLAD ALNKIGKKTM IALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLQQ
160 170 180 190 200
GNELGIDQRR IIWKRVLDLN DRALRHVIVG LGSPVNGVPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DLKDLKERLA NIVVAYDYNR KPVYVRDLKV EGALTLILRD
260 270 280 290 300
AIKPNLVQTI YGTPALVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LDIKVPNLPT SPDAVVVVAT LRALKMHGGV AKTDLNQENV
360 370 380 390 400
EAVRAGFANL ERHVNNMRQY GVPVVVAINE FVADTEAEIA VLKELCQSID
410 420 430 440 450
VPVELASVWA NGAEGGVALA ETVVKVIEQE KANYQRLYND QDSVEEKVRK
460 470 480 490 500
IVKNIYGGDA VQFSAKAKNQ LKQFAEFGWD KLPVCMAKTQ YSFSDNPNLL
510 520 530 540 550
GAPSGFDITI REFVPKTGAG FIVALTGDVM TMPGLPKHPA ALNMDVSEEG

TAIGLF
Length:556
Mass (Da):59,791
Last modified:March 24, 2009 - v1
Checksum:i947A67FAB67DAB44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM946015 Genomic DNA. Translation: CAR42098.1.
RefSeqiYP_002562268.1. NC_012004.1.

Genome annotation databases

EnsemblBacteriaiCAR42098; CAR42098; SUB0942.
GeneIDi7391410.
KEGGisub:SUB0942.
PATRICi19807580. VBIStrUbe20775_0910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM946015 Genomic DNA. Translation: CAR42098.1 .
RefSeqi YP_002562268.1. NC_012004.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218495.SUB0942.

Proteomic databases

PRIDEi B9DS83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR42098 ; CAR42098 ; SUB0942 .
GeneIDi 7391410.
KEGGi sub:SUB0942.
PATRICi 19807580. VBIStrUbe20775_0910.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SUBE218495:GJ7D-980-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-854 / 0140J.

Entry informationi

Entry nameiFTHS_STRU0
AccessioniPrimary (citable) accession number: B9DS83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3