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B9DRC8

- B9DRC8_STRU0

UniProt

B9DRC8 - B9DRC8_STRU0

Protein

Methionine--tRNA ligase

Gene

metG

Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611ZincUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. methionine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
    Alternative name(s):
    Methionyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:metGUniRule annotationImported
    Ordered Locus Names:SUB0459Imported
    OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)Imported
    Taxonomic identifieri218495 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000449: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi218495.SUBp02.

    Structurei

    3D structure databases

    ProteinModelPortaliB9DRC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini565 – 668104tRNA-bindingUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi14 – 2411"HIGH" regionUniRule annotationAdd
    BLAST
    Motifi311 – 3155"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.UniRule annotation
    Contains 1 tRNA-binding domain.UniRule annotation
    Contains tRNA-binding domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0143.
    KOiK01874.
    OMAiNQCIYVC.
    OrthoDBiEOG6CVV9B.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_01228. Met_tRNA_synth_type2.
    InterProiIPR014758. Met-tRNA_synth.
    IPR023457. Met-tRNA_synth_2.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR012340. NA-bd_OB-fold.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002547. tRNA-bd_dom.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PfamiPF09334. tRNA-synt_1g. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view]
    PRINTSiPR01041. TRNASYNTHMET.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00398. metG. 1 hit.
    PROSITEiPS50886. TRBD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9DRC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDKKPFYIT TPIYYPSGKL HIGSAYTTIA CDVLARYKRM MNHQVFYLTG    50
    LDEHGQKIQT KAEEAGITPQ EYVDGMAKGV KELWELLDIS YDKFIRTTDD 100
    YHEEVVAAVF EKLLAQDDIY LGEYSGWYSV SDEEFFTESQ LEEVFRDENG 150
    NVIGGIAPSG HEVEWVSEES YFLRLGKYAD KLVAFFNEHP EFIQPEGRMN 200
    EMIKNFIEPG LEDLAVSRTT FTWGVKVPSN PKHVVYVWID ALLNYATALG 250
    YGQEDKANFE TFWNNGTVFH MVGKDILRFH SIYWPILLMM LDMKLPERLI 300
    AHGWFVMKDG KMSKSKGNVV YPEMLVERFG LDPLRYYLMR SLPVGSDGTF 350
    TPEDYVGRIN YELANDLGNL LNRTVAMINK YFGGKIPAYT ENVTAFDGEL 400
    QDLVTEKITD YHKQMETVDY PRALDAIWAI ISRANKYIDE TAPWVLAKED 450
    GDKEQLASVM AHLAASLRVV AHLIQPFMMT TSNAIMEQLG LGQSFDLENL 500
    SLAGMPSDIT VISKGQPIFP RLDMEEEIAY IKEQMEGGSA IPQEKEWIPE 550
    EVDLKSEKEE IKFETFDACE IRVAEVKEVS KVEGSDKLLR FRLDAGDGED 600
    RQILSGIAKF YPNEQELVGK KLQIVANLKP RKMMKKYVSQ GMILSAEHDG 650
    KLTVLTVDPA VPNGSIIG 668
    Length:668
    Mass (Da):75,922
    Last modified:March 24, 2009 - v1
    Checksum:i93731954856237CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM946015 Genomic DNA. Translation: CAR41140.1.
    RefSeqiWP_012657994.1. NC_012004.1.
    YP_002561812.1. NC_012004.1.

    Genome annotation databases

    EnsemblBacteriaiCAR41140; CAR41140; SUB0459.
    GeneIDi7392232.
    KEGGisub:SUBp02.
    PATRICi19806638. VBIStrUbe20775_0440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM946015 Genomic DNA. Translation: CAR41140.1 .
    RefSeqi WP_012657994.1. NC_012004.1.
    YP_002561812.1. NC_012004.1.

    3D structure databases

    ProteinModelPortali B9DRC8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218495.SUBp02.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR41140 ; CAR41140 ; SUB0459 .
    GeneIDi 7392232.
    KEGGi sub:SUBp02.
    PATRICi 19806638. VBIStrUbe20775_0440.

    Phylogenomic databases

    eggNOGi COG0143.
    KOi K01874.
    OMAi NQCIYVC.
    OrthoDBi EOG6CVV9B.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_01228. Met_tRNA_synth_type2.
    InterProi IPR014758. Met-tRNA_synth.
    IPR023457. Met-tRNA_synth_2.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR012340. NA-bd_OB-fold.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002547. tRNA-bd_dom.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    Pfami PF09334. tRNA-synt_1g. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view ]
    PRINTSi PR01041. TRNASYNTHMET.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00398. metG. 1 hit.
    PROSITEi PS50886. TRBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-854 / 0140JImported.

    Entry informationi

    Entry nameiB9DRC8_STRU0
    AccessioniPrimary (citable) accession number: B9DRC8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3