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B9DRC8

- B9DRC8_STRU0

UniProt

B9DRC8 - B9DRC8_STRU0

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Protein
Methionine--tRNA ligase
Gene
metG, SUB0459
Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Zinc By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. methionine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationsImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
Alternative name(s):
Methionyl-tRNA synthetase
Gene namesi
Name:metGUniRule annotationImported
Ordered Locus Names:SUB0459Imported
OrganismiStreptococcus uberis (strain ATCC BAA-854 / 0140J)Imported
Taxonomic identifieri218495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000449: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi218495.SUBp02.

Structurei

3D structure databases

ProteinModelPortaliB9DRC8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini565 – 668104tRNA-binding By similarityUniRule annotation
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi14 – 2411"HIGH" region By similarityUniRule annotation
Add
BLAST
Motifi311 – 3155"KMSKS" region By similarityUniRule annotation

Sequence similaritiesi

Contains 1 tRNA-binding domain.UniRule annotation
Contains tRNA-binding domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG0143.
KOiK01874.
OMAiNQCIYVC.
OrthoDBiEOG6CVV9B.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_01228. Met_tRNA_synth_type2.
InterProiIPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiPS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9DRC8-1 [UniParc]FASTAAdd to Basket

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MTDKKPFYIT TPIYYPSGKL HIGSAYTTIA CDVLARYKRM MNHQVFYLTG    50
LDEHGQKIQT KAEEAGITPQ EYVDGMAKGV KELWELLDIS YDKFIRTTDD 100
YHEEVVAAVF EKLLAQDDIY LGEYSGWYSV SDEEFFTESQ LEEVFRDENG 150
NVIGGIAPSG HEVEWVSEES YFLRLGKYAD KLVAFFNEHP EFIQPEGRMN 200
EMIKNFIEPG LEDLAVSRTT FTWGVKVPSN PKHVVYVWID ALLNYATALG 250
YGQEDKANFE TFWNNGTVFH MVGKDILRFH SIYWPILLMM LDMKLPERLI 300
AHGWFVMKDG KMSKSKGNVV YPEMLVERFG LDPLRYYLMR SLPVGSDGTF 350
TPEDYVGRIN YELANDLGNL LNRTVAMINK YFGGKIPAYT ENVTAFDGEL 400
QDLVTEKITD YHKQMETVDY PRALDAIWAI ISRANKYIDE TAPWVLAKED 450
GDKEQLASVM AHLAASLRVV AHLIQPFMMT TSNAIMEQLG LGQSFDLENL 500
SLAGMPSDIT VISKGQPIFP RLDMEEEIAY IKEQMEGGSA IPQEKEWIPE 550
EVDLKSEKEE IKFETFDACE IRVAEVKEVS KVEGSDKLLR FRLDAGDGED 600
RQILSGIAKF YPNEQELVGK KLQIVANLKP RKMMKKYVSQ GMILSAEHDG 650
KLTVLTVDPA VPNGSIIG 668
Length:668
Mass (Da):75,922
Last modified:March 24, 2009 - v1
Checksum:i93731954856237CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM946015 Genomic DNA. Translation: CAR41140.1.
RefSeqiWP_012657994.1. NC_012004.1.
YP_002561812.1. NC_012004.1.

Genome annotation databases

EnsemblBacteriaiCAR41140; CAR41140; SUB0459.
GeneIDi7392232.
KEGGisub:SUBp02.
PATRICi19806638. VBIStrUbe20775_0440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM946015 Genomic DNA. Translation: CAR41140.1 .
RefSeqi WP_012657994.1. NC_012004.1.
YP_002561812.1. NC_012004.1.

3D structure databases

ProteinModelPortali B9DRC8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 218495.SUBp02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR41140 ; CAR41140 ; SUB0459 .
GeneIDi 7392232.
KEGGi sub:SUBp02.
PATRICi 19806638. VBIStrUbe20775_0440.

Phylogenomic databases

eggNOGi COG0143.
KOi K01874.
OMAi NQCIYVC.
OrthoDBi EOG6CVV9B.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_01228. Met_tRNA_synth_type2.
InterProi IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF09334. tRNA-synt_1g. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
PRINTSi PR01041. TRNASYNTHMET.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00398. metG. 1 hit.
PROSITEi PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-854 / 0140J.

Entry informationi

Entry nameiB9DRC8_STRU0
AccessioniPrimary (citable) accession number: B9DRC8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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