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Protein

Processive diacylglycerol beta-glucosyltransferase

Gene

ugtP

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).UniRule annotation

Catalytic activityi

UDP-alpha-D-glucose + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-(beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol + UDP.
UDP-glucose + 1,2-diacyl-sn-glycerol = UDP + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol.UniRule annotation

Pathwayi: diglucosyl-diacylglycerol biosynthesis

This protein is involved in the pathway diglucosyl-diacylglycerol biosynthesis, which is part of Glycolipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway diglucosyl-diacylglycerol biosynthesis and in Glycolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCarbohydrate metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSCAR396513:G1G1Q-638-MONOMER
UniPathwayiUPA00894

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
Processive diacylglycerol beta-glucosyltransferaseUniRule annotation (EC:2.4.1.315)
Alternative name(s):
Beta-diglucosyldiacylglycerol synthaseUniRule annotation
Short name:
Beta-DGSUniRule annotation
Short name:
DGlcDAG synthaseUniRule annotation
Short name:
Glc2-DAG synthaseUniRule annotation
Beta-gentiobiosyldiacylglycerol synthaseUniRule annotation
Beta-monoglucosyldiacylglycerol synthaseUniRule annotation
Short name:
Beta-MGSUniRule annotation
Short name:
MGlcDAG synthaseUniRule annotation
Diglucosyl diacylglycerol synthase (1,6-linking)
Glucosyl-beta-1,6-glucosyldiacylglycerol synthaseUniRule annotation
UDP glucosyltransferaseUniRule annotation
UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferaseUniRule annotation
Gene namesi
Name:ugtPUniRule annotation
Ordered Locus Names:Sca_0619
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001652351 – 391Processive diacylglycerol beta-glucosyltransferaseAdd BLAST391

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_0619

Structurei

3D structure databases

SMRiB9DQ98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. UgtP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108QBV Bacteria
COG0707 LUCA
HOGENOMiHOG000221565
KOiK03429
OMAiVTECLCA

Family and domain databases

HAMAPiMF_01280 Diacylglyc_glucosyltr, 1 hit
InterProiView protein in InterPro
IPR009695 Diacylglyc_glucosyltr_N
IPR007235 Glyco_trans_28_C
IPR023589 Pro_diacylglycrl_glcsylTrfase
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF06925 MGDG_synth, 1 hit

Sequencei

Sequence statusi: Complete.

B9DQ98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTQNKKILI ITGSFGNGHL QVTNSVVNQL NEMNLKHLSV IEHDLFMEAH
60 70 80 90 100
PILTSICKKY YINSFKYFRN SYKQFYYSRP EDVNKCFYKY YGLNKLINLL
110 120 130 140 150
IKEKPDLILL TFPTPVMSVL TEQFNMNIPI ATVMTDYRLH KNWVTPHSSR
160 170 180 190 200
YYVATPDLKQ EFVNVGVPED IIKITGIPIS EQFDEDIDTK VWMHKNHLDP
210 220 230 240 250
NRPTILMSAG AFGVSKGFDV MISDILERSP ETQIVMICGR NKELKRALRQ
260 270 280 290 300
QFKEYANVLI LGYTHHMNEW MASSHLMVTK PGGITISEAL ARKIPMIFLD
310 320 330 340 350
PAPGQELENA HYFQSKGMGK IADTTEEAIQ LITELTQDEN ALAHMAEQMQ
360 370 380 390
DLKVKYPTYK LCRDLLHLLD HSSQFEEIYG KVPMYAKLFI K
Length:391
Mass (Da):45,153
Last modified:March 24, 2009 - v1
Checksum:iE8791136429A8FCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295250 Genomic DNA Translation: CAL27533.1
RefSeqiWP_015899876.1, NC_012121.1

Genome annotation databases

KEGGisca:SCA_0619

Similar proteinsi

Entry informationi

Entry nameiUGTP_STACT
AccessioniPrimary (citable) accession number: B9DQ98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 25, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health