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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAR396513:G1G1Q-708-MONOMER
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:Sca_0688
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001229301 – 234Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST234

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_0688

Structurei

3D structure databases

ProteinModelPortaliB9DQ35
SMRiB9DQ35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8V Bacteria
COG0152 LUCA
HOGENOMiHOG000082629
KOiK01923
OMAiFNAQKRG

Family and domain databases

CDDicd01415 SAICAR_synt_PurC, 1 hit
HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR033934 SAICAR_synt_PurC
IPR001636 SAICAR_synth
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR00081 purC, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit
PS01058 SAICAR_SYNTHETASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B9DQ35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLYEGKAK RIFSTDEDGV LRVEYKDEVT AGNGAKKDHI DGKGRLNNQI
60 70 80 90 100
TSIIFEHLKK HGIKSHFIEQ TSETEQLVRS VEIIPLEVVV RNIAAGSITK
110 120 130 140 150
RLGFEKGHEF ETPLVEFFYK NDDLNDPLIT DDHVKLLNIA NDEEIAKLKK
160 170 180 190 200
MALEINKALV EMLDSINLRL VDFKIEFGRT EDGDILLADE ISPDTCRIWE
210 220 230
KDSDTNFDKD VYREDRGSII DTYQTFLNKL EALK
Length:234
Mass (Da):26,802
Last modified:March 24, 2009 - v1
Checksum:i0A7A5858655C81E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295250 Genomic DNA Translation: CAL27599.1
RefSeqiWP_015899942.1, NC_012121.1

Genome annotation databases

KEGGisca:SCA_0688

Similar proteinsi

Entry informationi

Entry nameiPUR7_STACT
AccessioniPrimary (citable) accession number: B9DQ35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health