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B9DNZ3 (B9DNZ3_STACT) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169

EC=1.2.4.2 HAMAP-Rule MF_01169
Alternative name(s):
Alpha-ketoglutarate dehydrogenase HAMAP-Rule MF_01169
Gene names
Name:odhA HAMAP-Rule MF_01169 EMBL CAL27966.1
Ordered Locus Names:Sca_1058 EMBL CAL27966.1
ORF Names:SCA_1058 EMBL CAL27966.1
OrganismStaphylococcus carnosus (strain TM300) [Complete proteome] [HAMAP]
Taxonomic identifier396513 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length931 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. SAAS SAAS023784 HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. SAAS SAAS023784 HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family. HAMAP-Rule MF_01169

Sequences

Sequence LengthMass (Da)Tools
B9DNZ3 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 5F7C559FD4DF1E5E

FASTA931105,560
        10         20         30         40         50         60 
MTKDKQVSEA PVNFGANLGV IIDLYDQYLQ DPTSVSEDLQ ILFSTINNDN REVAASPASS 

        70         80         90        100        110        120 
SSDSTIKQVM RLVDNIRQYG HLQSDIYPVN RPERKHVPKL TIEDFNLSKD DLEKISPGIV 

       130        140        150        160        170        180 
SDHFSDIYDY AYEAIKRMEK RYKGPIAFEY THINNNTERT WLKRRIETPY KADLNKNQKI 

       190        200        210        220        230        240 
NLFKTLAHVE GFEKYLHKNF VGAKRFSIEG VDTLVPMLQE TLRRAAKEEI KNIQIGMAHR 

       250        260        270        280        290        300 
GRLNVLTHVL EKPYEMMISE FMHTDPMKFL PEDGSLELTS GNAWTSDVKY HLGGIKTTDT 

       310        320        330        340        350        360 
YGTEQRISLA NNPSHLEIVA PVVLGKTRSV QDDTHEGGKV QTDFSKSMPI LIHGDAAYPG 

       370        380        390        400        410        420 
QGINFEAMNL GNLDGYSTGG SLHIITNNRI GFTTEARDGR STTYSTDVAK GYDIPIMHVN 

       430        440        450        460        470        480 
ADNVEATIEA IDIAMDFRKE FNKDVVIDLV GYRRYGHNEM DEPSITNPLP YHAIRKHPTV 

       490        500        510        520        530        540 
DKIYGEQLVD EGVISKEEME QTLDDVQKEL RNSHDKIDKN DKTTTKDMSK PESVEEPLQP 

       550        560        570        580        590        600 
DKNNVSYDDL KTINDALLTY PTGFEVLKKL NKVLEKRREP FEKEDGLVDW AQAEQLAFAT 

       610        620        630        640        650        660 
IMQNGTPIRL TGQDSERGTF SHRHAVLHNP DNGDEYVPLQ NVPNQKASFD VHNSPLSEAA 

       670        680        690        700        710        720 
VVGFEYGYNV ENKGTMNIWE AQYGDFANMA QMMFDNFLFS SYAKWGERSG LTLFLPHSYE 

       730        740        750        760        770        780 
GQGPEHSSAR LERFLQLSAE NNSTVVNLSS SANYYHLLRA QAASLDTDAM RPLVVMSPKS 

       790        800        810        820        830        840 
LLRNKTVADT IDKFTEGYFK PILPEAHDEK KIKKLILASG KMFIDLKERL QKEPDESILL 

       850        860        870        880        890        900 
VAVERLYPFP VEEVREVINS LPNLETIAWV QEEPQNQGAW SFVYPYLSDL ASDKYELQYS 

       910        920        930 
GRIKRSAPAE GDGENHKLVQ NSIIEESLNK N 

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References

[1]"Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TM300 EMBL CAL27966.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM295250 Genomic DNA. Translation: CAL27966.1.
RefSeqYP_002634151.1. NC_012121.1.

3D structure databases

ProteinModelPortalB9DNZ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING396513.Sca_1058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7551878.
KEGGsca:Sca_1058.
PATRIC19602884. VBIStaCar105558_1056.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMANEGVANE.
OrthoDBEOG6V1M1F.
ProtClustDBPRK09404.

Enzyme and pathway databases

BioCycSCAR396513:GJ9G-1071-MONOMER.

Family and domain databases

HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB9DNZ3_STACT
AccessionPrimary (citable) accession number: B9DNZ3
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)