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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Staphylococcus carnosus (strain TM300)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

Cofactori

thiamine diphosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processGlycolysisUniRule annotationSAAS annotation
LigandThiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSCAR396513:G1G1Q-1067-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotationSAAS annotation (EC:1.2.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotationImported
Ordered Locus Names:Sca_1058Imported
OrganismiStaphylococcus carnosus (strain TM300)Imported
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi396513.Sca_1058

Structurei

3D structure databases

ProteinModelPortaliB9DNZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini588 – 784Transket_pyrInterPro annotationAdd BLAST197

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili496 – 516Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C7P Bacteria
COG0567 LUCA
HOGENOMiHOG000259588
KOiK00164
OMAiIDMVCYR

Family and domain databases

HAMAPiMF_01169 SucA_OdhA, 1 hit
InterProiView protein in InterPro
IPR011603 2oxoglutarate_DH_E1
IPR023784 2oxoglutarate_DH_E1_bac
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequencei

Sequence statusi: Complete.

B9DNZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDKQVSEA PVNFGANLGV IIDLYDQYLQ DPTSVSEDLQ ILFSTINNDN
60 70 80 90 100
REVAASPASS SSDSTIKQVM RLVDNIRQYG HLQSDIYPVN RPERKHVPKL
110 120 130 140 150
TIEDFNLSKD DLEKISPGIV SDHFSDIYDY AYEAIKRMEK RYKGPIAFEY
160 170 180 190 200
THINNNTERT WLKRRIETPY KADLNKNQKI NLFKTLAHVE GFEKYLHKNF
210 220 230 240 250
VGAKRFSIEG VDTLVPMLQE TLRRAAKEEI KNIQIGMAHR GRLNVLTHVL
260 270 280 290 300
EKPYEMMISE FMHTDPMKFL PEDGSLELTS GNAWTSDVKY HLGGIKTTDT
310 320 330 340 350
YGTEQRISLA NNPSHLEIVA PVVLGKTRSV QDDTHEGGKV QTDFSKSMPI
360 370 380 390 400
LIHGDAAYPG QGINFEAMNL GNLDGYSTGG SLHIITNNRI GFTTEARDGR
410 420 430 440 450
STTYSTDVAK GYDIPIMHVN ADNVEATIEA IDIAMDFRKE FNKDVVIDLV
460 470 480 490 500
GYRRYGHNEM DEPSITNPLP YHAIRKHPTV DKIYGEQLVD EGVISKEEME
510 520 530 540 550
QTLDDVQKEL RNSHDKIDKN DKTTTKDMSK PESVEEPLQP DKNNVSYDDL
560 570 580 590 600
KTINDALLTY PTGFEVLKKL NKVLEKRREP FEKEDGLVDW AQAEQLAFAT
610 620 630 640 650
IMQNGTPIRL TGQDSERGTF SHRHAVLHNP DNGDEYVPLQ NVPNQKASFD
660 670 680 690 700
VHNSPLSEAA VVGFEYGYNV ENKGTMNIWE AQYGDFANMA QMMFDNFLFS
710 720 730 740 750
SYAKWGERSG LTLFLPHSYE GQGPEHSSAR LERFLQLSAE NNSTVVNLSS
760 770 780 790 800
SANYYHLLRA QAASLDTDAM RPLVVMSPKS LLRNKTVADT IDKFTEGYFK
810 820 830 840 850
PILPEAHDEK KIKKLILASG KMFIDLKERL QKEPDESILL VAVERLYPFP
860 870 880 890 900
VEEVREVINS LPNLETIAWV QEEPQNQGAW SFVYPYLSDL ASDKYELQYS
910 920 930
GRIKRSAPAE GDGENHKLVQ NSIIEESLNK N
Length:931
Mass (Da):105,560
Last modified:March 24, 2009 - v1
Checksum:i5F7C559FD4DF1E5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295250 Genomic DNA Translation: CAL27966.1
RefSeqiWP_015900307.1, NC_012121.1

Genome annotation databases

KEGGisca:SCA_1058

Similar proteinsi

Entry informationi

Entry nameiB9DNZ3_STACT
AccessioniPrimary (citable) accession number: B9DNZ3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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