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B9DNN6 (GCSPA_STACT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Sca_1160
OrganismStaphylococcus carnosus (strain TM300) [Complete proteome] [HAMAP]
Taxonomic identifier396513 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147991

Sequences

Sequence LengthMass (Da)Tools
B9DNN6 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: C1697FFB80A44042

FASTA44849,668
        10         20         30         40         50         60 
MSHRYIPLTE KDKQEMLETI GANSIEELFG DVPKEILLDR ELDIPNGEDE TTLLKRLSRI 

        70         80         90        100        110        120 
AKKNITKEDY TSFLGAGVYD HYTPAVVDAM ISRSEFYTAY TPYQPEISQG ELQAIFEFQT 

       130        140        150        160        170        180 
LICELTGMDV ANSSMYDGIT AFAEACILAF SQTKKNKIVV SKGLHYQALQ VLHTYSKIRN 

       190        200        210        220        230        240 
DYEIVEVDLD GTVTDLEKLE DAIDDETAAV AVQYPNFYGS IEDLEKIKSL IKNKKTLFIV 

       250        260        270        280        290        300 
YTNPLSLGLL TPPGDFGADI VVGDTQPFGI PAQFGGPHCG FFATTKKLMR KVPGRLVGQT 

       310        320        330        340        350        360 
EDDHGNRGFV LTLQAREQHI RRDKATSNIC SNQALNALAS SIAMSALGKQ GLQDIAVQNF 

       370        380        390        400        410        420 
ENANYAKNQF KDAGIEVLPG TSFNEFVIKL DKPVKEVNDK LLEEGIIGGF DLSEVNEEFG 

       430        440 
QAMLIAVTEL RTKDEIDTFV KKVGEING 

« Hide

References

[1]"Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TM300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM295250 Genomic DNA. Translation: CAL28068.1.
RefSeqYP_002634253.1. NC_012121.1.

3D structure databases

ProteinModelPortalB9DNN6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING396513.Sca_1160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7551618.
KEGGsca:Sca_1160.
PATRIC19603090. VBIStaCar105558_1159.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycSCAR396513:GJ9G-1173-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_STACT
AccessionPrimary (citable) accession number: B9DNN6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families