Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAR396513:G1G1Q-1339-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sca_1337
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001852631 – 555Formate--tetrahydrofolate ligaseAdd BLAST555

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_1337

Structurei

3D structure databases

SMRiB9DN77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

B9DN77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHLSDLDIA NQATIKPISE IAEKIGIPED ALEQYGHYKA KIDINKLDDK
60 70 80 90 100
GDRGKVVLVT AMSPTPAGEG KSTVTVGLAD AFHELGENVM MALREPALGP
110 120 130 140 150
VFGIKGGATG GGYAQVLPME DINLHFNGDF HAITTANNAL AAFIDNHIHQ
160 170 180 190 200
GNELGIDQRR IEWKRVLDMN DRELRKVVVG LGGPTQGVPR EDGFNITVAS
210 220 230 240 250
EIMTILCLST GLKDLKASIA NITIGYTRDR KPVTVADLKV EGALAMILKD
260 270 280 290 300
AIKPNLVQSI EGTPALIHGG PFANIAHGCN SIIATETARK LADIVVTEAG
310 320 330 340 350
FGSDLGAEKF MNIKARKAGF EPSAAVVVAT IRALKMHGGV AKDDLKEENV
360 370 380 390 400
QAVRDGLANL ERHIENIRSF GVEPVVALNA FVSDTEAEEQ VVEDWAKEHG
410 420 430 440 450
VRIALTEVWE KGGKGGVELA KQVQEVLNEK HDFKHTYDLD LPIEEKIEKV
460 470 480 490 500
VTNIYGGNKV TFTSGALKQL KQIKENGWDN YPVCMAKTQY SFTDDKDRLG
510 520 530 540 550
APDDFEITIR ELQPKTGAGF IVALTGAIMT MPGLPKKPAA LNMDVTEDGH

AKGLF
Length:555
Mass (Da):59,962
Last modified:March 24, 2009 - v1
Checksum:iE66582F8793796D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295250 Genomic DNA Translation: CAL28242.1
RefSeqiWP_015900582.1, NC_012121.1

Genome annotation databases

KEGGisca:SCA_1337

Similar proteinsi

Entry informationi

Entry nameiFTHS_STACT
AccessioniPrimary (citable) accession number: B9DN77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 25, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health