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B9DN77

- FTHS_STACT

UniProt

B9DN77 - FTHS_STACT

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Sca_1337
Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAR396513:GJ9G-1347-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Sca_1337
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000444: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000185263Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_1337.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9DN77-1 [UniParc]FASTAAdd to Basket

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MTHLSDLDIA NQATIKPISE IAEKIGIPED ALEQYGHYKA KIDINKLDDK    50
GDRGKVVLVT AMSPTPAGEG KSTVTVGLAD AFHELGENVM MALREPALGP 100
VFGIKGGATG GGYAQVLPME DINLHFNGDF HAITTANNAL AAFIDNHIHQ 150
GNELGIDQRR IEWKRVLDMN DRELRKVVVG LGGPTQGVPR EDGFNITVAS 200
EIMTILCLST GLKDLKASIA NITIGYTRDR KPVTVADLKV EGALAMILKD 250
AIKPNLVQSI EGTPALIHGG PFANIAHGCN SIIATETARK LADIVVTEAG 300
FGSDLGAEKF MNIKARKAGF EPSAAVVVAT IRALKMHGGV AKDDLKEENV 350
QAVRDGLANL ERHIENIRSF GVEPVVALNA FVSDTEAEEQ VVEDWAKEHG 400
VRIALTEVWE KGGKGGVELA KQVQEVLNEK HDFKHTYDLD LPIEEKIEKV 450
VTNIYGGNKV TFTSGALKQL KQIKENGWDN YPVCMAKTQY SFTDDKDRLG 500
APDDFEITIR ELQPKTGAGF IVALTGAIMT MPGLPKKPAA LNMDVTEDGH 550
AKGLF 555
Length:555
Mass (Da):59,962
Last modified:March 24, 2009 - v1
Checksum:iE66582F8793796D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295250 Genomic DNA. Translation: CAL28242.1.
RefSeqiYP_002634427.1. NC_012121.1.

Genome annotation databases

GeneIDi7552128.
KEGGisca:Sca_1337.
PATRICi19603440. VBIStaCar105558_1334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295250 Genomic DNA. Translation: CAL28242.1 .
RefSeqi YP_002634427.1. NC_012121.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 396513.Sca_1337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7552128.
KEGGi sca:Sca_1337.
PATRICi 19603440. VBIStaCar105558_1334.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SCAR396513:GJ9G-1347-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
    Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
    Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM300.

Entry informationi

Entry nameiFTHS_STACT
AccessioniPrimary (citable) accession number: B9DN77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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