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B9DMZ9

- B9DMZ9_STACT

UniProt

B9DMZ9 - B9DMZ9_STACT

Protein

Ferrochelatase

Gene

hemH

Organism
Staphylococcus carnosus (strain TM300)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

    Catalytic activityi

    Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi183 – 1831IronUniRule annotation
    Metal bindingi265 – 2651IronUniRule annotation

    GO - Molecular functioni

    1. ferrochelatase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Heme biosynthesisUniRule annotationSAAS annotation, Porphyrin biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    IronUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciSCAR396513:GJ9G-1425-MONOMER.
    UniPathwayiUPA00252; UER00325.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
    Alternative name(s):
    Heme synthaseUniRule annotation
    Protoheme ferro-lyaseUniRule annotation
    Gene namesi
    Name:hemHUniRule annotationImported
    Ordered Locus Names:Sca_1407Imported
    ORF Names:SCA_1407Imported
    OrganismiStaphylococcus carnosus (strain TM300)Imported
    Taxonomic identifieri396513 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000444: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi396513.Sca_1407.

    Structurei

    3D structure databases

    ProteinModelPortaliB9DMZ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ferrochelatase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0276.
    HOGENOMiHOG000060729.
    KOiK01772.
    OMAiHYEIGWQ.
    OrthoDBiEOG6XHC5H.

    Family and domain databases

    HAMAPiMF_00323. Ferrochelatase.
    InterProiIPR001015. Ferrochelatase.
    [Graphical view]
    PANTHERiPTHR11108. PTHR11108. 1 hit.
    PfamiPF00762. Ferrochelatase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00109. hemH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9DMZ9-1 [UniParc]FASTAAdd to Basket

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    MTKTVGLLVM AYGTPYKESD IEAYYTDIRH GKKPSPEEVQ DLKDRYKFIG    50
    GISPLAKITD EQAEALKDNL NLMYKDKDIE FKLYVGLKHI HPYIEDALKQ 100
    MNEDGIEEAV TIVLAPHFSN FSVGSYDKRA DEEAEKYGIR LMHVKSFYQQ 150
    PKFIQYWVKQ INKTLSDIPE EEQDDTVLVV SAHSLPEKMI VESHDPYPHQ 200
    LADTKNLLEE LSNVKHAAQG WQSEGNTGTP WLGPDVQDLT RTLYQEHGYK 250
    HFIYTPVGFV CNHLEVLYDN DHECKVVCDE IGAEYHRPPM PNTDPLFIGA 300
    MADEVYSVFS VKEVGQHD 318
    Length:318
    Mass (Da):36,428
    Last modified:March 24, 2009 - v1
    Checksum:i694297864694D131
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM295250 Genomic DNA. Translation: CAL28312.1.
    RefSeqiYP_002634497.1. NC_012121.1.

    Genome annotation databases

    GeneIDi7551687.
    KEGGisca:Sca_1407.
    PATRICi19603600. VBIStaCar105558_1406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM295250 Genomic DNA. Translation: CAL28312.1 .
    RefSeqi YP_002634497.1. NC_012121.1.

    3D structure databases

    ProteinModelPortali B9DMZ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 396513.Sca_1407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7551687.
    KEGGi sca:Sca_1407.
    PATRICi 19603600. VBIStaCar105558_1406.

    Phylogenomic databases

    eggNOGi COG0276.
    HOGENOMi HOG000060729.
    KOi K01772.
    OMAi HYEIGWQ.
    OrthoDBi EOG6XHC5H.

    Enzyme and pathway databases

    UniPathwayi UPA00252 ; UER00325 .
    BioCyci SCAR396513:GJ9G-1425-MONOMER.

    Family and domain databases

    HAMAPi MF_00323. Ferrochelatase.
    InterProi IPR001015. Ferrochelatase.
    [Graphical view ]
    PANTHERi PTHR11108. PTHR11108. 1 hit.
    Pfami PF00762. Ferrochelatase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00109. hemH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
      Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
      Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TM300Imported.

    Entry informationi

    Entry nameiB9DMZ9_STACT
    AccessioniPrimary (citable) accession number: B9DMZ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3