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Protein

Ferrochelatase

Gene

hemH

Organism
Staphylococcus carnosus (strain TM300)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi183 – 1831IronUniRule annotation
Metal bindingi265 – 2651IronUniRule annotation

GO - Molecular functioni

  1. ferrochelatase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Heme biosynthesisUniRule annotationSAAS annotation, Porphyrin biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

IronUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSCAR396513:GJ9G-1425-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotationSAAS annotation (EC:4.99.1.1UniRule annotationSAAS annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotationImported
Ordered Locus Names:Sca_1407Imported
ORF Names:SCA_1407Imported
OrganismiStaphylococcus carnosus (strain TM300)Imported
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000444 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_1407.

Structurei

3D structure databases

ProteinModelPortaliB9DMZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0276.
HOGENOMiHOG000060729.
KOiK01772.
OMAiESWYDEP.
OrthoDBiEOG6XHC5H.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.

Sequencei

Sequence statusi: Complete.

B9DMZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTVGLLVM AYGTPYKESD IEAYYTDIRH GKKPSPEEVQ DLKDRYKFIG
60 70 80 90 100
GISPLAKITD EQAEALKDNL NLMYKDKDIE FKLYVGLKHI HPYIEDALKQ
110 120 130 140 150
MNEDGIEEAV TIVLAPHFSN FSVGSYDKRA DEEAEKYGIR LMHVKSFYQQ
160 170 180 190 200
PKFIQYWVKQ INKTLSDIPE EEQDDTVLVV SAHSLPEKMI VESHDPYPHQ
210 220 230 240 250
LADTKNLLEE LSNVKHAAQG WQSEGNTGTP WLGPDVQDLT RTLYQEHGYK
260 270 280 290 300
HFIYTPVGFV CNHLEVLYDN DHECKVVCDE IGAEYHRPPM PNTDPLFIGA
310
MADEVYSVFS VKEVGQHD
Length:318
Mass (Da):36,428
Last modified:March 24, 2009 - v1
Checksum:i694297864694D131
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295250 Genomic DNA. Translation: CAL28312.1.
RefSeqiWP_015900652.1. NC_012121.1.
YP_002634497.1. NC_012121.1.

Genome annotation databases

KEGGisca:Sca_1407.
PATRICi19603600. VBIStaCar105558_1406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295250 Genomic DNA. Translation: CAL28312.1.
RefSeqiWP_015900652.1. NC_012121.1.
YP_002634497.1. NC_012121.1.

3D structure databases

ProteinModelPortaliB9DMZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi396513.Sca_1407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGisca:Sca_1407.
PATRICi19603600. VBIStaCar105558_1406.

Phylogenomic databases

eggNOGiCOG0276.
HOGENOMiHOG000060729.
KOiK01772.
OMAiESWYDEP.
OrthoDBiEOG6XHC5H.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.
BioCyciSCAR396513:GJ9G-1425-MONOMER.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
    Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
    Appl. Environ. Microbiol. 75:811-822(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM300Imported.

Entry informationi

Entry nameiB9DMZ9_STACT
AccessioniPrimary (citable) accession number: B9DMZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 1, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.