B9DKM0 (DEOB_STACT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphopentomutase
EC=5.4.2.7

Alternative name(s):
Phosphodeoxyribomutase

Gene names

Name:	deoB
Ordered Locus Names:	Sca_2011

Organism

Staphylococcus carnosus (strain TM300) [Complete proteome] [HAMAP]

Taxonomic identifier

396513 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus carnosus › Staphylococcus carnosus subsp. carnosus

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphotransfer between the C1 and C5 carbon atoms of pentose By similarity. HAMAP-Rule MF_00740
Catalytic activity	Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate. HAMAP-Rule MF_00740 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate. HAMAP-Rule MF_00740
Cofactor	Binds 1 or 2 manganese ions Potential.
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3. HAMAP-Rule MF_00740
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphopentomutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	5-phosphoribose 1-diphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cellular metabolic compound salvage Inferred from electronic annotation. Source: InterPro deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: HAMAP phosphopentomutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Phosphopentomutase HAMAP-Rule MF_00740		PRO_1000148251
Sites
	Metal binding	14	1	Manganese By similarity
	Metal binding	291	1	Manganese By similarity
	Metal binding	327	1	Manganese By similarity
	Metal binding	328	1	Manganese By similarity
	Metal binding	339	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9DKM0 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 9002F8DADD35ED38	FASTA	396	44,366
	10 20 30 40 50 60 MTTPFKRIHL IVMDSVGIGE GPDAAAFNDE GSHTLKHTLE GFEQDLPNLQ RLGLGNIAPL 70 80 90 100 110 120 PVVEEVEQPE AFYTKLSEAS VGKDTMTGHW EIMGLNIMQP FKVYPDGFPD ELVKEIEDMT 130 140 150 160 170 180 GRKVVANRPA SGTQIIDEWG EHQMKTGDLI VYTSADPVLQ IAAHEDVIPL EELYDICEKV 190 200 210 220 230 240 RELTKDPKYL IGRIIARPYV GEPGNFTRTS NRHDYALKPF GRTVMNELKD NNYDVIAIGK 250 260 270 280 290 300 INDIYDGEGV TEAIRTKNNM DGMDKLIDVV KHDFTGISFL NLVDFDALYG HRRDKEGYAQ 310 320 330 340 350 360 AIKDFDERLP ELIDNLQEDD LVIITADHGN DPIAPGTDHT REYIPVLLYS PKLKDKAHEL 370 380 390 SGDTTFSSIG ATIADNFDVP LPEYGRSFLS EMNVEK

References

[1]

"Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300." Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F. Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TM300.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM295250 Genomic DNA. Translation: CAL28916.1.
RefSeq	YP_002635101.1. NC_012121.1.
3D structure databases
ProteinModelPortal	B9DKM0.
ModBase	Search...
Protein-protein interaction databases
STRING	396513.Sca_2011.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7550983.
KEGG	sca:Sca_2011.
PATRIC	19604894. VBIStaCar105558_2009.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1015.
HOGENOM	HOG000008159.
KO	K01839.
OMA	PNMAKLG.
ProtClustDB	PRK05362.
Enzyme and pathway databases
BioCyc	SCAR396513:GJ9G-2072-MONOMER.
UniPathway	UPA00087; UER00173.
Family and domain databases
Gene3D	3.30.70.1250. 1 hit. 3.40.720.10. 2 hits.
HAMAP	MF_00740. Phosphopentomut.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR010045. DeoB. IPR006124. Metalloenzyme. IPR024052. Phosphopentomutase_DeoB_cap. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. [Graphical view]
PIRSF	PIRSF001491. Ppentomutase. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit. SSF143856. SSF143856. 1 hit.
TIGRFAMs	TIGR01696. deoB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOB_STACT

Accession

Primary (citable) accession number: B9DKM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program