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B9DK59 (UPPP_STACT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Sca_0330
OrganismStaphylococcus carnosus (strain TM300) [Complete proteome] [HAMAP]
Taxonomic identifier396513 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148826

Regions

Transmembrane48 – 6821Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane208 – 22821Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane272 – 29221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B9DK59 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: E3D849BAC5256A95

FASTA29633,147
        10         20         30         40         50         60 
MLLLELLKAL ILGIVEGLTE FAPVSSTGHM ILVDDMWLKS PEFLGSQSAF TFKIVIQLGS 

        70         80         90        100        110        120 
VFAAAWVFRK RYFEMLYIGK YQPAATETES ADGKIGKRVK PKRLTLWHVL VGMIPAGILG 

       130        140        150        160        170        180 
LLFDDVIEKY LFSVPTVMIG LLLGAFYMIF AQKFSERYAH RENIDQITFF QAFVIGLSQA 

       190        200        210        220        230        240 
VAMWPGFSRS GSTISTGVLM KMNYKAASDF TFIMAVPIML AASLLSLVKH IGYIHLSHIP 

       250        260        270        280        290 
FYIIGFLAAF IFGLLSIRLF LNLINRIKLI PFAIYRIILV IFIAILYFGF GIGKGI 

« Hide

References

[1]"Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TM300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM295250 Genomic DNA. Translation: CAL27243.1.
RefSeqYP_002633428.1. NC_012121.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING396513.Sca_0330.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7549983.
KEGGsca:Sca_0330.
PATRIC19601421. VBIStaCar105558_0329.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAWRKISSS.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSCAR396513:GJ9G-344-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_STACT
AccessionPrimary (citable) accession number: B9DK59
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families