B9DJG9 (AROD_STACT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	Sca_0448

Organism

Staphylococcus carnosus (strain TM300) [Complete proteome] [HAMAP]

Taxonomic identifier

396513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000124785
Sites
	Active site	132	1	Proton acceptor By similarity
	Active site	159	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9DJG9 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 711B41E9413699CE	FASTA	241	26,990
	10 20 30 40 50 60 MSKVDVAVTI APKEEITDQL KKDLIREQKS IDIIELRIDQ RESFEIADLE RLFKTLKDLQ 70 80 90 100 110 120 LDVQVLVTYR TSVQGGKGQK NGNTYYEFLQ DLIQIQGYDM VDIEWDEAQT EILLQLIVQA 130 140 150 160 170 180 QSAGLKVVLS QHDFDKTPNL EVLKFLYFKM NKLGADIVKL AVMPNEKQDV LNLLEALATA 190 200 210 220 230 240 SESIEAKPVG ISMSHLGLIS RTAQGVFGGI ISYGCLGTPQ APGQIHVGQL KELLNIYEIN K

References

[1]

"Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300." Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F. Appl. Environ. Microbiol. 75:811-822(2009) [PubMed: 19060169] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TM300.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM295250 Genomic DNA. Translation: CAL27362.1.
RefSeq	YP_002633547.1. NC_012121.1.
3D structure databases
ProteinModelPortal	B9DJG9.
ModBase	Search...
Protein-protein interaction databases
STRING	B9DJG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000050987; EBSTAP00000049157; EBSTAG00000051490.
GeneID	7550057.
GenomeReviews	Gene locus Sca_0448 in contig AM295250_GR.
KEGG	sca:Sca_0448.
PATRIC	19601664. VBIStaCar105558_0449.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000025297.
OMA	IAKIAVM.
ProtClustDB	PRK13575.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STACT

Accession

Primary (citable) accession number: B9DJG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program