Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD kinase

Gene

nadK

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei149NADUniRule annotation1
Binding sitei151NADUniRule annotation1
Binding sitei186NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 46NADUniRule annotation2
Nucleotide bindingi122 – 123NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAR396513:G1G1Q-627-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Sca_0608
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001925201 – 269NAD kinaseAdd BLAST269

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_0608

Structurei

3D structure databases

SMRiB9DIP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B9DIP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYNIVSKGD HKSNSIKENM EAQMQDTKMI KDTETPEIVI SVGGDGTLLE
60 70 80 90 100
AFHKYSYRLS ETAFVGVHTG HLGFYADWLP HESDKLIREI IDGDYEVIKY
110 120 130 140 150
PLIDITVNYN DEKNPSHHIA LNEATMKTED NTTLVADVSL RGQHFERFRG
160 170 180 190 200
DGLCISTPSG STAYNKALGG ALIHPSLRAI QLTEIASINN RVFRTVGSPL
210 220 230 240 250
VLPAHHYCLI TPVDQRTIMT SIDHVTTKHH NVKSIEYKVS EEEIRFARFR
260
PFPFWKRVHD SFISDGRDD
Length:269
Mass (Da):30,542
Last modified:March 24, 2009 - v1
Checksum:i8133CD983543BB1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295250 Genomic DNA Translation: CAL27522.1
RefSeqiWP_015899865.1, NC_012121.1

Genome annotation databases

KEGGisca:SCA_0608

Similar proteinsi

Entry informationi

Entry nameiNADK_STACT
AccessioniPrimary (citable) accession number: B9DIP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health