B9DI94 (RNPA_STACT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component
Short name=RNase P protein
Short name=RNaseP protein
EC=3.1.26.5

Alternative name(s):
Protein C5

Gene names

Name:	rnpA
Ordered Locus Names:	Sca_0002

Organism

Staphylococcus carnosus (strain TM300) [Complete proteome] [HAMAP]

Taxonomic identifier

396513 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus carnosus › Staphylococcus carnosus subsp. carnosus

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity. HAMAP-Rule MF_00227
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00227
Subunit structure	Consists of a catalytic RNA component (M1 or RnpB) and a protein subunit By similarity.
Sequence similarities	Belongs to the RnpA family.

Ontologies

Keywords
Biological process	tRNA processing
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: EC tRNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 115	115	Ribonuclease P protein component HAMAP-Rule MF_00227		PRO_1000194672

Sequences

	Sequence		Length	Mass (Da)
	B9DI94 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 6B981C42EF54CB71	FASTA	115	13,489
	10 20 30 40 50 60 MEKAYRIKKN SDFQAIYRRG KSVANRQFVI YMMPDKGLTH FKLGISVSKK LGNAVTRNRI 70 80 90 100 110 KRAIRENFKV HKDDMLPRNI IVIARHPAKD MTVLEIQKSL EHVLKVAKLF NKRIK

References

[1]

"Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300." Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F. Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TM300.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM295250 Genomic DNA. Translation: CAL26917.1.
RefSeq	YP_002633102.1. NC_012121.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	396513.Sca_0002.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7552069.
KEGG	sca:Sca_0002.
PATRIC	19600734. VBIStaCar105558_0002.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0594.
HOGENOM	HOG000266301.
KO	K03536.
OMA	KIGNAVM.
ProtClustDB	PRK00499.
Enzyme and pathway databases
BioCyc	SCAR396513:GJ9G-2-MONOMER.
Family and domain databases
Gene3D	3.30.230.10. 1 hit.
HAMAP	MF_00227. RNase_P.
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR000100. RNase_P. IPR020539. RNase_P_CS. [Graphical view]
Pfam	PF00825. Ribonuclease_P. 1 hit. [Graphical view]
ProDom	PD003629. Ribonuclease_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00188. rnpA. 1 hit.
PROSITE	PS00648. RIBONUCLEASE_P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNPA_STACT

Accession

Primary (citable) accession number: B9DI94

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 29, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program