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Protein

Basic leucine zipper 63

Gene

BZIP63

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cellular response to abscisic acid stimulus Source: TAIR
  • cellular response to glucose stimulus Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper 63
Short name:
AtbZIP63
Short name:
bZIP protein 63
Alternative name(s):
Basic leucine zipper OPAQUE 2 homolog 3
Short name:
Basic leucine zipper O2 homolog 3
Gene namesi
Name:BZIP63
Synonyms:BZO2H3
Ordered Locus Names:At5g28770
ORF Names:T32B20.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G28770.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi160S → A: Normal DNA-binding. 1 Publication1
Mutagenesisi160S → D: Reduced DNA-binding to C-box motif. 1 Publication1
Mutagenesisi164S → A: Normal DNA-binding. 1 Publication1
Mutagenesisi164S → D: Impaired DNA-binding to C-box motif. 1 Publication1
Mutagenesisi168S → A: Normal DNA-binding. 1 Publication1
Mutagenesisi168S → D: Impaired DNA-binding to C-box motif. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004165601 – 314Basic leucine zipper 63Add BLAST314

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB9DGI8.

PTM databases

iPTMnetiB9DGI8.

Expressioni

Tissue specificityi

Expressed in roots, shoots, young leaves, pollen, and flowers.2 Publications

Developmental stagei

Present in silique valves, vasculature and funiculi.1 Publication

Inductioni

Strongly repressed by glucose.1 Publication

Gene expression databases

GenevisibleiB9DGI8. AT.

Interactioni

Subunit structurei

Homodimer. Forms a heterodimer with LSD1, BZIP1, BZIP2, BZIP9, BZIP10, BZIP11, BZIP25, BZIP44 and BZIP53.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-942713,EBI-942713
BZIP1Q9FGX24EBI-942713,EBI-942623
BZIP11O656834EBI-942713,EBI-942769
BZIP2Q9SI154EBI-942713,EBI-942735
BZIP44C0Z2L54EBI-942713,EBI-942804
BZIP53Q9LZP88EBI-942713,EBI-942845

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi18262. 12 interactors.
IntActiB9DGI8. 10 interactors.
STRINGi3702.AT5G28770.2.

Structurei

3D structure databases

ProteinModelPortaliB9DGI8.
SMRiB9DGI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 214bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 172Basic motifPROSITE-ProRule annotationAdd BLAST20
Regioni179 – 193Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi155 – 162Nuclear localization signal 1By similarity8
Motifi295 – 302Nuclear localization signal 2By similarity8

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIE6. Eukaryota.
ENOG4111S51. LUCA.
HOGENOMiHOG000240492.
InParanoidiB9DGI8.
OMAiSEENMSH.
OrthoDBiEOG09360JUP.
PhylomeDBiB9DGI8.

Family and domain databases

InterProiIPR020983. Basic_leucine-zipper_C.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF12498. bZIP_C. 2 hits.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B9DGI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKVFSDEEI SGNHHWSVNG MTSLNRSASE WAFNRFIQES SAAADDGEST
60 70 80 90 100
TACGVSVSSP PNVPVDSEEY RAFLKSKLNL ACAAVAMKRG TFIKPQDTSG
110 120 130 140 150
RSDNGGANES EQASLASSKA TPMMSSAITS GSELSGDEEE ADGETNMNPT
160 170 180 190 200
NVKRVKRMLS NRESARRSRR RKQAHLSELE TQVSQLRVEN SKLMKGLTDV
210 220 230 240 250
TQTFNDASVE NRVLKANIET LRAKVKMAEE TVKRLTGFNP MFHNMPQIVS
260 270 280 290 300
TVSLPSETSN SPDTTSSQVT TPEIISSGNK GKALIGCKMN RTASMRRVES
310
LEHLQKRIRS VGDQ
Length:314
Mass (Da):34,311
Last modified:March 24, 2009 - v1
Checksum:i37B85F20425DFF8B
GO
Isoform 2 (identifier: B9DGI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-96: Missing.

Note: No experimental confirmation available.
Show »
Length:307
Mass (Da):33,539
Checksum:i11175239863775E8
GO
Isoform 3 (identifier: B9DGI8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-250: MAEETVKRLTGFNPMFHNMPQIVS → YFLLSLCLPKLAIEACLFLAGENG
     251-314: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:250
Mass (Da):27,233
Checksum:i16D69752D095BE62
GO

Sequence cautioni

The sequence AAF67360 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAC79656 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04264190 – 96Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_042642227 – 250MAEET…PQIVS → YFLLSLCLPKLAIEACLFLA GENG in isoform 3. CuratedAdd BLAST24
Alternative sequenceiVSP_042643251 – 314Missing in isoform 3. CuratedAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262041 Genomic DNA. Translation: AAF67360.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED93832.1.
CP002688 Genomic DNA. Translation: AED93833.1.
CP002688 Genomic DNA. Translation: AED93834.1.
AF446876 mRNA. Translation: AAL38609.1.
AY052688 mRNA. Translation: AAK96592.1.
AK317169 mRNA. Translation: BAH19855.1.
AF310224 mRNA. Translation: AAG25729.1.
AJ010858 mRNA. Translation: CAC79656.1. Different initiation.
RefSeqiNP_001031962.1. NM_001036885.2. [B9DGI8-3]
NP_568508.2. NM_122760.4. [B9DGI8-1]
NP_851088.1. NM_180757.3. [B9DGI8-2]
UniGeneiAt.15754.

Genome annotation databases

EnsemblPlantsiAT5G28770.2; AT5G28770.2; AT5G28770. [B9DGI8-1]
GeneIDi832990.
GrameneiAT5G28770.2; AT5G28770.2; AT5G28770.
KEGGiath:AT5G28770.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262041 Genomic DNA. Translation: AAF67360.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED93832.1.
CP002688 Genomic DNA. Translation: AED93833.1.
CP002688 Genomic DNA. Translation: AED93834.1.
AF446876 mRNA. Translation: AAL38609.1.
AY052688 mRNA. Translation: AAK96592.1.
AK317169 mRNA. Translation: BAH19855.1.
AF310224 mRNA. Translation: AAG25729.1.
AJ010858 mRNA. Translation: CAC79656.1. Different initiation.
RefSeqiNP_001031962.1. NM_001036885.2. [B9DGI8-3]
NP_568508.2. NM_122760.4. [B9DGI8-1]
NP_851088.1. NM_180757.3. [B9DGI8-2]
UniGeneiAt.15754.

3D structure databases

ProteinModelPortaliB9DGI8.
SMRiB9DGI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi18262. 12 interactors.
IntActiB9DGI8. 10 interactors.
STRINGi3702.AT5G28770.2.

PTM databases

iPTMnetiB9DGI8.

Proteomic databases

PaxDbiB9DGI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G28770.2; AT5G28770.2; AT5G28770. [B9DGI8-1]
GeneIDi832990.
GrameneiAT5G28770.2; AT5G28770.2; AT5G28770.
KEGGiath:AT5G28770.

Organism-specific databases

TAIRiAT5G28770.

Phylogenomic databases

eggNOGiENOG410IIE6. Eukaryota.
ENOG4111S51. LUCA.
HOGENOMiHOG000240492.
InParanoidiB9DGI8.
OMAiSEENMSH.
OrthoDBiEOG09360JUP.
PhylomeDBiB9DGI8.

Miscellaneous databases

PROiB9DGI8.

Gene expression databases

GenevisibleiB9DGI8. AT.

Family and domain databases

InterProiIPR020983. Basic_leucine-zipper_C.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF12498. bZIP_C. 2 hits.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBZP63_ARATH
AccessioniPrimary (citable) accession number: B9DGI8
Secondary accession number(s): F4KA11
, Q712P1, Q940U4, Q9FUD2, Q9LKT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.