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Protein

Cytochrome P450 711A1

Gene

CYP711A1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts carlactone to carlactonoic acid by catalyzing consecutive oxidations at C-19 to convert the C-19 methyl group into carboxylic acid (PubMed:25425668). Prefers 11R-carlactone to 11S-carlactone as substrate (PubMed:25425668). Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds (PubMed:15737939, PubMed:16387852).3 Publications

Miscellaneous

The branching phenotypes of the max1, ccd7/max3 and ccd8/max4 mutants can be rescued by exogenous treatment with the synthetic strigolactone analogs GR24 and 4BD.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi467Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • auxin polar transport Source: TAIR
  • carotenoid biosynthetic process Source: TAIR
  • positive regulation of flavonoid biosynthetic process Source: TAIR
  • regulation of meristem structural organization Source: TAIR
  • secondary shoot formation Source: TAIR

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-211958 Miscellaneous substrates
R-ATH-211979 Eicosanoids
R-ATH-211981 Xenobiotics
R-ATH-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-ATH-5423646 Aflatoxin activation and detoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 711A1 (EC:1.14.-.-)
Alternative name(s):
Protein MORE AXILLARY BRANCHES 1
Gene namesi
Name:CYP711A1
Synonyms:MAX1
Ordered Locus Names:At2g26170
ORF Names:T19L18.2, T1D16.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G26170
TAIRilocus:2057361 AT2G26170

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increased shoot branching.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004220621 – 522Cytochrome P450 711A1Add BLAST522

Proteomic databases

PaxDbiB9DFU2

Expressioni

Tissue specificityi

Expressed in the vascular cylinder (including the pericycle) in roots, the cambial region of vascular bundles in inflorescence stems and the vascular junctions of axillary regions in leaves and flowers.1 Publication

Gene expression databases

ExpressionAtlasiB9DFU2 baseline and differential
GenevisibleiB9DFU2 AT

Interactioni

Protein-protein interaction databases

BioGridi2509, 1 interactor
STRINGi3702.AT2G26170.1

Structurei

3D structure databases

ProteinModelPortaliB9DFU2
SMRiB9DFU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
HOGENOMiHOG000238198
InParanoidiB9DFU2
KOiK20771
OMAiIAGYEIV
OrthoDBiEOG093601OY
PhylomeDBiB9DFU2

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B9DFU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTQHQWWEV LDPFLTQHEA LIAFLTFAAV VIVIYLYRPS WSVCNVPGPT
60 70 80 90 100
AMPLVGHLPL MAKYGPDVFS VLAKQYGPIF RFQMGRQPLI IIAEAELCRE
110 120 130 140 150
VGIKKFKDLP NRSIPSPISA SPLHKKGLFF TRDKRWSKMR NTILSLYQPS
160 170 180 190 200
HLTSLIPTMH SFITSATHNL DSKPRDIVFS NLFLKLTTDI IGQAAFGVDF
210 220 230 240 250
GLSGKKPIKD VEVTDFINQH VYSTTQLKMD LSGSLSIILG LLIPILQEPF
260 270 280 290 300
RQVLKRIPGT MDWRVEKTNA RLSGQLNEIV SKRAKEAETD SKDFLSLILK
310 320 330 340 350
ARESDPFAKN IFTSDYISAV TYEHLLAGSA TTAFTLSSVL YLVSGHLDVE
360 370 380 390 400
KRLLQEIDGF GNRDLIPTAH DLQHKFPYLD QVIKEAMRFY MVSPLVARET
410 420 430 440 450
AKEVEIGGYL LPKGTWVWLA LGVLAKDPKN FPEPEKFKPE RFDPNGEEEK
460 470 480 490 500
HRHPYAFIPF GIGPRACVGQ RFALQEIKLT LLHLYRNYIF RHSLEMEIPL
510 520
QLDYGIILSF KNGVKLRTIK RF
Length:522
Mass (Da):59,425
Last modified:May 3, 2011 - v1
Checksum:i77E46CD65838398F
GO
Isoform 2 (identifier: B9DFU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:439
Mass (Da):49,951
Checksum:i68C5335CC020A2AA
GO

Sequence cautioni

The sequence AAL91286 differs from that shown. Reason: Frameshift at position 102.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0463231 – 83Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004484 Genomic DNA Translation: AAC14532.2
AC004747 Genomic DNA Translation: AAM15001.1
CP002685 Genomic DNA Translation: AEC07803.1
CP002685 Genomic DNA Translation: AEC07804.1
AY054283 mRNA Translation: AAL06942.1
AY090384 mRNA Translation: AAL91286.1 Frameshift.
AK316903 mRNA Translation: BAH19609.1
PIRiT02607
RefSeqiNP_565617.2, NM_128175.3 [B9DFU2-1]
NP_850074.1, NM_179743.2 [B9DFU2-2]
UniGeneiAt.26382
At.48520

Genome annotation databases

EnsemblPlantsiAT2G26170.1; AT2G26170.1; AT2G26170 [B9DFU2-1]
AT2G26170.2; AT2G26170.2; AT2G26170 [B9DFU2-2]
GeneIDi817157
GrameneiAT2G26170.1; AT2G26170.1; AT2G26170 [B9DFU2-1]
AT2G26170.2; AT2G26170.2; AT2G26170 [B9DFU2-2]
KEGGiath:AT2G26170

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMAX1_ARATH
AccessioniPrimary (citable) accession number: B9DFU2
Secondary accession number(s): O64853, Q940L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health