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B9DFU2 (MAX1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 711A1

EC=1.14.-.-
Alternative name(s):
Protein MORE AXILLARY BRANCHES 1
Gene names
Name:CYP711A1
Synonyms:MAX1
Ordered Locus Names:At2g26170
ORF Names:T19L18.2, T1D16.2
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds. Ref.5 Ref.6

Cofactor

Heme group By similarity.

Subcellular location

Membrane Potential; Single-pass membrane protein.

Tissue specificity

Expressed in the vascular cylinder (including the pericycle) in roots, the cambial region of vascular bundles in inflorescence stems and the vascular junctions of axillary regions in leaves and flowers. Ref.5

Disruption phenotype

Increased shoot branching. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9

Miscellaneous

The branching phenotypes of the max1, ccd7/max3 and ccd8/max4 mutants can be rescued by exogenous treatment with the synthetic strigolactone analogs GR24 and 4BD (Ref.9).

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence caution

The sequence AAL91286.1 differs from that shown. Reason: Frameshift at position 102.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B9DFU2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: B9DFU2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Cytochrome P450 711A1
PRO_0000422062

Regions

Transmembrane14 – 3421Helical; Potential

Sites

Metal binding4671Iron (heme axial ligand) By similarity

Natural variations

Alternative sequence1 – 8383Missing in isoform 2.
VSP_046323

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 77E46CD65838398F

FASTA52259,425
        10         20         30         40         50         60 
MKTQHQWWEV LDPFLTQHEA LIAFLTFAAV VIVIYLYRPS WSVCNVPGPT AMPLVGHLPL 

        70         80         90        100        110        120 
MAKYGPDVFS VLAKQYGPIF RFQMGRQPLI IIAEAELCRE VGIKKFKDLP NRSIPSPISA 

       130        140        150        160        170        180 
SPLHKKGLFF TRDKRWSKMR NTILSLYQPS HLTSLIPTMH SFITSATHNL DSKPRDIVFS 

       190        200        210        220        230        240 
NLFLKLTTDI IGQAAFGVDF GLSGKKPIKD VEVTDFINQH VYSTTQLKMD LSGSLSIILG 

       250        260        270        280        290        300 
LLIPILQEPF RQVLKRIPGT MDWRVEKTNA RLSGQLNEIV SKRAKEAETD SKDFLSLILK 

       310        320        330        340        350        360 
ARESDPFAKN IFTSDYISAV TYEHLLAGSA TTAFTLSSVL YLVSGHLDVE KRLLQEIDGF 

       370        380        390        400        410        420 
GNRDLIPTAH DLQHKFPYLD QVIKEAMRFY MVSPLVARET AKEVEIGGYL LPKGTWVWLA 

       430        440        450        460        470        480 
LGVLAKDPKN FPEPEKFKPE RFDPNGEEEK HRHPYAFIPF GIGPRACVGQ RFALQEIKLT 

       490        500        510        520 
LLHLYRNYIF RHSLEMEIPL QLDYGIILSF KNGVKLRTIK RF 

« Hide

Isoform 2 [UniParc].

Checksum: 68C5335CC020A2AA
Show »

FASTA43949,951

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: cv. Columbia.
[4]"Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[5]"MAX1 encodes a cytochrome P450 family member that acts downstream of MAX3/4 to produce a carotenoid-derived branch-inhibiting hormone."
Booker J., Sieberer T., Wright W., Williamson L., Willett B., Stirnberg P., Turnbull C., Srinivasan M., Goddard P., Leyser O.
Dev. Cell 8:443-449(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[6]"MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis."
Lazar G., Goodman H.M.
Proc. Natl. Acad. Sci. U.S.A. 103:472-476(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[7]"Strigolactones enhance competition between shoot branches by dampening auxin transport."
Crawford S., Shinohara N., Sieberer T., Williamson L., George G., Hepworth J., Mueller D., Domagalska M.A., Leyser O.
Development 137:2905-2913(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[8]"Strigolactones are transported through the xylem and play a key role in shoot architectural response to phosphate deficiency in nonarbuscular mycorrhizal host Arabidopsis."
Kohlen W., Charnikhova T., Liu Q., Bours R., Domagalska M.A., Beguerie S., Verstappen F., Leyser O., Bouwmeester H., Ruyter-Spira C.
Plant Physiol. 155:974-987(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[9]"Selective mimics of strigolactone actions and their potential use for controlling damage caused by root parasitic weeds."
Fukui K., Ito S., Asami T.
Mol. Plant 6:88-99(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC004484 Genomic DNA. Translation: AAC14532.2.
AC004747 Genomic DNA. Translation: AAM15001.1.
CP002685 Genomic DNA. Translation: AEC07803.1.
CP002685 Genomic DNA. Translation: AEC07804.1.
AY054283 mRNA. Translation: AAL06942.1.
AY090384 mRNA. Translation: AAL91286.1. Frameshift.
AK316903 mRNA. Translation: BAH19609.1.
PIRT02607.
RefSeqNP_565617.2. NM_128175.3.
NP_850074.1. NM_179743.2.
UniGeneAt.26382.
At.48520.

3D structure databases

ProteinModelPortalB9DFU2.
SMRB9DFU2. Positions 46-521.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEB9DFU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G26170.1; AT2G26170.1; AT2G26170. [B9DFU2-1]
GeneID817157.
KEGGath:AT2G26170.

Organism-specific databases

GeneFarm1383. 94.
TAIRAT2G26170.

Phylogenomic databases

OMAVGHLPLM.
PhylomeDBB9DFU2.
ProtClustDBCLSN2918099.

Gene expression databases

ArrayExpressB9DFU2.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMAX1_ARATH
AccessionPrimary (citable) accession number: B9DFU2
Secondary accession number(s): O64853, Q940L3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: May 3, 2011
Last modified: April 16, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names