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B9DFU2

- MAX1_ARATH

UniProt

B9DFU2 - MAX1_ARATH

Protein

Cytochrome P450 711A1

Gene

CYP711A1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.2 Publications

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi467 – 4671Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    GO - Biological processi

    1. auxin polar transport Source: TAIR
    2. carotenoid biosynthetic process Source: TAIR
    3. positive regulation of flavonoid biosynthetic process Source: TAIR
    4. regulation of meristem structural organization Source: TAIR
    5. secondary shoot formation Source: TAIR

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 711A1 (EC:1.14.-.-)
    Alternative name(s):
    Protein MORE AXILLARY BRANCHES 1
    Gene namesi
    Name:CYP711A1
    Synonyms:MAX1
    Ordered Locus Names:At2g26170
    ORF Names:T19L18.2, T1D16.2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G26170.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Increased shoot branching.5 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Cytochrome P450 711A1PRO_0000422062Add
    BLAST

    Proteomic databases

    PRIDEiB9DFU2.

    Expressioni

    Tissue specificityi

    Expressed in the vascular cylinder (including the pericycle) in roots, the cambial region of vascular bundles in inflorescence stems and the vascular junctions of axillary regions in leaves and flowers.1 Publication

    Gene expression databases

    ArrayExpressiB9DFU2.

    Structurei

    3D structure databases

    ProteinModelPortaliB9DFU2.
    SMRiB9DFU2. Positions 46-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OMAiFITSATH.
    PhylomeDBiB9DFU2.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B9DFU2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKTQHQWWEV LDPFLTQHEA LIAFLTFAAV VIVIYLYRPS WSVCNVPGPT    50
    AMPLVGHLPL MAKYGPDVFS VLAKQYGPIF RFQMGRQPLI IIAEAELCRE 100
    VGIKKFKDLP NRSIPSPISA SPLHKKGLFF TRDKRWSKMR NTILSLYQPS 150
    HLTSLIPTMH SFITSATHNL DSKPRDIVFS NLFLKLTTDI IGQAAFGVDF 200
    GLSGKKPIKD VEVTDFINQH VYSTTQLKMD LSGSLSIILG LLIPILQEPF 250
    RQVLKRIPGT MDWRVEKTNA RLSGQLNEIV SKRAKEAETD SKDFLSLILK 300
    ARESDPFAKN IFTSDYISAV TYEHLLAGSA TTAFTLSSVL YLVSGHLDVE 350
    KRLLQEIDGF GNRDLIPTAH DLQHKFPYLD QVIKEAMRFY MVSPLVARET 400
    AKEVEIGGYL LPKGTWVWLA LGVLAKDPKN FPEPEKFKPE RFDPNGEEEK 450
    HRHPYAFIPF GIGPRACVGQ RFALQEIKLT LLHLYRNYIF RHSLEMEIPL 500
    QLDYGIILSF KNGVKLRTIK RF 522
    Length:522
    Mass (Da):59,425
    Last modified:May 3, 2011 - v1
    Checksum:i77E46CD65838398F
    GO
    Isoform 2 (identifier: B9DFU2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: Missing.

    Show »
    Length:439
    Mass (Da):49,951
    Checksum:i68C5335CC020A2AA
    GO

    Sequence cautioni

    The sequence AAL91286.1 differs from that shown. Reason: Frameshift at position 102.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8383Missing in isoform 2. 1 PublicationVSP_046323Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004484 Genomic DNA. Translation: AAC14532.2.
    AC004747 Genomic DNA. Translation: AAM15001.1.
    CP002685 Genomic DNA. Translation: AEC07803.1.
    CP002685 Genomic DNA. Translation: AEC07804.1.
    AY054283 mRNA. Translation: AAL06942.1.
    AY090384 mRNA. Translation: AAL91286.1. Frameshift.
    AK316903 mRNA. Translation: BAH19609.1.
    PIRiT02607.
    RefSeqiNP_565617.2. NM_128175.3. [B9DFU2-1]
    NP_850074.1. NM_179743.2. [B9DFU2-2]
    UniGeneiAt.26382.
    At.48520.

    Genome annotation databases

    EnsemblPlantsiAT2G26170.1; AT2G26170.1; AT2G26170. [B9DFU2-1]
    GeneIDi817157.
    KEGGiath:AT2G26170.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004484 Genomic DNA. Translation: AAC14532.2 .
    AC004747 Genomic DNA. Translation: AAM15001.1 .
    CP002685 Genomic DNA. Translation: AEC07803.1 .
    CP002685 Genomic DNA. Translation: AEC07804.1 .
    AY054283 mRNA. Translation: AAL06942.1 .
    AY090384 mRNA. Translation: AAL91286.1 . Frameshift.
    AK316903 mRNA. Translation: BAH19609.1 .
    PIRi T02607.
    RefSeqi NP_565617.2. NM_128175.3. [B9DFU2-1 ]
    NP_850074.1. NM_179743.2. [B9DFU2-2 ]
    UniGenei At.26382.
    At.48520.

    3D structure databases

    ProteinModelPortali B9DFU2.
    SMRi B9DFU2. Positions 46-521.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B9DFU2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G26170.1 ; AT2G26170.1 ; AT2G26170 . [B9DFU2-1 ]
    GeneIDi 817157.
    KEGGi ath:AT2G26170.

    Organism-specific databases

    GeneFarmi 1383. 94.
    TAIRi AT2G26170.

    Phylogenomic databases

    OMAi FITSATH.
    PhylomeDBi B9DFU2.

    Gene expression databases

    ArrayExpressi B9DFU2.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
      Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
      DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. "MAX1 encodes a cytochrome P450 family member that acts downstream of MAX3/4 to produce a carotenoid-derived branch-inhibiting hormone."
      Booker J., Sieberer T., Wright W., Williamson L., Willett B., Stirnberg P., Turnbull C., Srinivasan M., Goddard P., Leyser O.
      Dev. Cell 8:443-449(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    6. "MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis."
      Lazar G., Goodman H.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:472-476(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    7. "Strigolactones enhance competition between shoot branches by dampening auxin transport."
      Crawford S., Shinohara N., Sieberer T., Williamson L., George G., Hepworth J., Mueller D., Domagalska M.A., Leyser O.
      Development 137:2905-2913(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    8. "Strigolactones are transported through the xylem and play a key role in shoot architectural response to phosphate deficiency in nonarbuscular mycorrhizal host Arabidopsis."
      Kohlen W., Charnikhova T., Liu Q., Bours R., Domagalska M.A., Beguerie S., Verstappen F., Leyser O., Bouwmeester H., Ruyter-Spira C.
      Plant Physiol. 155:974-987(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    9. "Selective mimics of strigolactone actions and their potential use for controlling damage caused by root parasitic weeds."
      Fukui K., Ito S., Asami T.
      Mol. Plant 6:88-99(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiMAX1_ARATH
    AccessioniPrimary (citable) accession number: B9DFU2
    Secondary accession number(s): O64853, Q940L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2013
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The branching phenotypes of the max1, ccd7/max3 and ccd8/max4 mutants can be rescued by exogenous treatment with the synthetic strigolactone analogs GR24 and 4BD.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3