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Protein

Cytochrome P450 711A1

Gene

CYP711A1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.2 Publications

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi467 – 4671Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • auxin polar transport Source: TAIR
  • carotenoid biosynthetic process Source: TAIR
  • positive regulation of flavonoid biosynthetic process Source: TAIR
  • regulation of meristem structural organization Source: TAIR
  • secondary shoot formation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 711A1 (EC:1.14.-.-)
Alternative name(s):
Protein MORE AXILLARY BRANCHES 1
Gene namesi
Name:CYP711A1
Synonyms:MAX1
Ordered Locus Names:At2g26170
ORF Names:T19L18.2, T1D16.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G26170.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increased shoot branching.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Cytochrome P450 711A1PRO_0000422062Add
BLAST

Proteomic databases

PRIDEiB9DFU2.

Expressioni

Tissue specificityi

Expressed in the vascular cylinder (including the pericycle) in roots, the cambial region of vascular bundles in inflorescence stems and the vascular junctions of axillary regions in leaves and flowers.1 Publication

Gene expression databases

ExpressionAtlasiB9DFU2. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi2509. 1 interaction.
STRINGi3702.AT2G26170.1.

Structurei

3D structure databases

ProteinModelPortaliB9DFU2.
SMRiB9DFU2. Positions 46-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000238198.
InParanoidiB9DFU2.
OMAiFITSATH.
PhylomeDBiB9DFU2.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B9DFU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTQHQWWEV LDPFLTQHEA LIAFLTFAAV VIVIYLYRPS WSVCNVPGPT
60 70 80 90 100
AMPLVGHLPL MAKYGPDVFS VLAKQYGPIF RFQMGRQPLI IIAEAELCRE
110 120 130 140 150
VGIKKFKDLP NRSIPSPISA SPLHKKGLFF TRDKRWSKMR NTILSLYQPS
160 170 180 190 200
HLTSLIPTMH SFITSATHNL DSKPRDIVFS NLFLKLTTDI IGQAAFGVDF
210 220 230 240 250
GLSGKKPIKD VEVTDFINQH VYSTTQLKMD LSGSLSIILG LLIPILQEPF
260 270 280 290 300
RQVLKRIPGT MDWRVEKTNA RLSGQLNEIV SKRAKEAETD SKDFLSLILK
310 320 330 340 350
ARESDPFAKN IFTSDYISAV TYEHLLAGSA TTAFTLSSVL YLVSGHLDVE
360 370 380 390 400
KRLLQEIDGF GNRDLIPTAH DLQHKFPYLD QVIKEAMRFY MVSPLVARET
410 420 430 440 450
AKEVEIGGYL LPKGTWVWLA LGVLAKDPKN FPEPEKFKPE RFDPNGEEEK
460 470 480 490 500
HRHPYAFIPF GIGPRACVGQ RFALQEIKLT LLHLYRNYIF RHSLEMEIPL
510 520
QLDYGIILSF KNGVKLRTIK RF
Length:522
Mass (Da):59,425
Last modified:May 3, 2011 - v1
Checksum:i77E46CD65838398F
GO
Isoform 2 (identifier: B9DFU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:439
Mass (Da):49,951
Checksum:i68C5335CC020A2AA
GO

Sequence cautioni

The sequence AAL91286.1 differs from that shown. Reason: Frameshift at position 102. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383Missing in isoform 2. 1 PublicationVSP_046323Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004484 Genomic DNA. Translation: AAC14532.2.
AC004747 Genomic DNA. Translation: AAM15001.1.
CP002685 Genomic DNA. Translation: AEC07803.1.
CP002685 Genomic DNA. Translation: AEC07804.1.
AY054283 mRNA. Translation: AAL06942.1.
AY090384 mRNA. Translation: AAL91286.1. Frameshift.
AK316903 mRNA. Translation: BAH19609.1.
PIRiT02607.
RefSeqiNP_565617.2. NM_128175.3. [B9DFU2-1]
NP_850074.1. NM_179743.2. [B9DFU2-2]
UniGeneiAt.26382.
At.48520.

Genome annotation databases

EnsemblPlantsiAT2G26170.1; AT2G26170.1; AT2G26170. [B9DFU2-1]
GeneIDi817157.
KEGGiath:AT2G26170.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004484 Genomic DNA. Translation: AAC14532.2.
AC004747 Genomic DNA. Translation: AAM15001.1.
CP002685 Genomic DNA. Translation: AEC07803.1.
CP002685 Genomic DNA. Translation: AEC07804.1.
AY054283 mRNA. Translation: AAL06942.1.
AY090384 mRNA. Translation: AAL91286.1. Frameshift.
AK316903 mRNA. Translation: BAH19609.1.
PIRiT02607.
RefSeqiNP_565617.2. NM_128175.3. [B9DFU2-1]
NP_850074.1. NM_179743.2. [B9DFU2-2]
UniGeneiAt.26382.
At.48520.

3D structure databases

ProteinModelPortaliB9DFU2.
SMRiB9DFU2. Positions 46-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2509. 1 interaction.
STRINGi3702.AT2G26170.1.

Proteomic databases

PRIDEiB9DFU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G26170.1; AT2G26170.1; AT2G26170. [B9DFU2-1]
GeneIDi817157.
KEGGiath:AT2G26170.

Organism-specific databases

GeneFarmi1383. 94.
TAIRiAT2G26170.

Phylogenomic databases

HOGENOMiHOG000238198.
InParanoidiB9DFU2.
OMAiFITSATH.
PhylomeDBiB9DFU2.

Miscellaneous databases

PROiB9DFU2.

Gene expression databases

ExpressionAtlasiB9DFU2. baseline and differential.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "MAX1 encodes a cytochrome P450 family member that acts downstream of MAX3/4 to produce a carotenoid-derived branch-inhibiting hormone."
    Booker J., Sieberer T., Wright W., Williamson L., Willett B., Stirnberg P., Turnbull C., Srinivasan M., Goddard P., Leyser O.
    Dev. Cell 8:443-449(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis."
    Lazar G., Goodman H.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:472-476(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "Strigolactones enhance competition between shoot branches by dampening auxin transport."
    Crawford S., Shinohara N., Sieberer T., Williamson L., George G., Hepworth J., Mueller D., Domagalska M.A., Leyser O.
    Development 137:2905-2913(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  8. "Strigolactones are transported through the xylem and play a key role in shoot architectural response to phosphate deficiency in nonarbuscular mycorrhizal host Arabidopsis."
    Kohlen W., Charnikhova T., Liu Q., Bours R., Domagalska M.A., Beguerie S., Verstappen F., Leyser O., Bouwmeester H., Ruyter-Spira C.
    Plant Physiol. 155:974-987(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  9. "Selective mimics of strigolactone actions and their potential use for controlling damage caused by root parasitic weeds."
    Fukui K., Ito S., Asami T.
    Mol. Plant 6:88-99(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiMAX1_ARATH
AccessioniPrimary (citable) accession number: B9DFU2
Secondary accession number(s): O64853, Q940L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: May 3, 2011
Last modified: June 24, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The branching phenotypes of the max1, ccd7/max3 and ccd8/max4 mutants can be rescued by exogenous treatment with the synthetic strigolactone analogs GR24 and 4BD.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.