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B9DFU2

- MAX1_ARATH

UniProt

B9DFU2 - MAX1_ARATH

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Protein

Cytochrome P450 711A1

Gene
CYP711A1, MAX1, At2g26170, T19L18.2, T1D16.2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.2 Publications

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi467 – 4671Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

GO - Biological processi

  1. auxin polar transport Source: TAIR
  2. carotenoid biosynthetic process Source: TAIR
  3. positive regulation of flavonoid biosynthetic process Source: TAIR
  4. regulation of meristem structural organization Source: TAIR
  5. secondary shoot formation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 711A1 (EC:1.14.-.-)
Alternative name(s):
Protein MORE AXILLARY BRANCHES 1
Gene namesi
Name:CYP711A1
Synonyms:MAX1
Ordered Locus Names:At2g26170
ORF Names:T19L18.2, T1D16.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G26170.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increased shoot branching.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Cytochrome P450 711A1PRO_0000422062Add
BLAST

Proteomic databases

PRIDEiB9DFU2.

Expressioni

Tissue specificityi

Expressed in the vascular cylinder (including the pericycle) in roots, the cambial region of vascular bundles in inflorescence stems and the vascular junctions of axillary regions in leaves and flowers.1 Publication

Gene expression databases

ArrayExpressiB9DFU2.

Structurei

3D structure databases

ProteinModelPortaliB9DFU2.
SMRiB9DFU2. Positions 46-521.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OMAiFITSATH.
PhylomeDBiB9DFU2.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B9DFU2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKTQHQWWEV LDPFLTQHEA LIAFLTFAAV VIVIYLYRPS WSVCNVPGPT    50
AMPLVGHLPL MAKYGPDVFS VLAKQYGPIF RFQMGRQPLI IIAEAELCRE 100
VGIKKFKDLP NRSIPSPISA SPLHKKGLFF TRDKRWSKMR NTILSLYQPS 150
HLTSLIPTMH SFITSATHNL DSKPRDIVFS NLFLKLTTDI IGQAAFGVDF 200
GLSGKKPIKD VEVTDFINQH VYSTTQLKMD LSGSLSIILG LLIPILQEPF 250
RQVLKRIPGT MDWRVEKTNA RLSGQLNEIV SKRAKEAETD SKDFLSLILK 300
ARESDPFAKN IFTSDYISAV TYEHLLAGSA TTAFTLSSVL YLVSGHLDVE 350
KRLLQEIDGF GNRDLIPTAH DLQHKFPYLD QVIKEAMRFY MVSPLVARET 400
AKEVEIGGYL LPKGTWVWLA LGVLAKDPKN FPEPEKFKPE RFDPNGEEEK 450
HRHPYAFIPF GIGPRACVGQ RFALQEIKLT LLHLYRNYIF RHSLEMEIPL 500
QLDYGIILSF KNGVKLRTIK RF 522
Length:522
Mass (Da):59,425
Last modified:May 3, 2011 - v1
Checksum:i77E46CD65838398F
GO
Isoform 2 (identifier: B9DFU2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:439
Mass (Da):49,951
Checksum:i68C5335CC020A2AA
GO

Sequence cautioni

The sequence AAL91286.1 differs from that shown. Reason: Frameshift at position 102.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383Missing in isoform 2. VSP_046323Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004484 Genomic DNA. Translation: AAC14532.2.
AC004747 Genomic DNA. Translation: AAM15001.1.
CP002685 Genomic DNA. Translation: AEC07803.1.
CP002685 Genomic DNA. Translation: AEC07804.1.
AY054283 mRNA. Translation: AAL06942.1.
AY090384 mRNA. Translation: AAL91286.1. Frameshift.
AK316903 mRNA. Translation: BAH19609.1.
PIRiT02607.
RefSeqiNP_565617.2. NM_128175.3. [B9DFU2-1]
NP_850074.1. NM_179743.2. [B9DFU2-2]
UniGeneiAt.26382.
At.48520.

Genome annotation databases

EnsemblPlantsiAT2G26170.1; AT2G26170.1; AT2G26170. [B9DFU2-1]
GeneIDi817157.
KEGGiath:AT2G26170.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004484 Genomic DNA. Translation: AAC14532.2 .
AC004747 Genomic DNA. Translation: AAM15001.1 .
CP002685 Genomic DNA. Translation: AEC07803.1 .
CP002685 Genomic DNA. Translation: AEC07804.1 .
AY054283 mRNA. Translation: AAL06942.1 .
AY090384 mRNA. Translation: AAL91286.1 . Frameshift.
AK316903 mRNA. Translation: BAH19609.1 .
PIRi T02607.
RefSeqi NP_565617.2. NM_128175.3. [B9DFU2-1 ]
NP_850074.1. NM_179743.2. [B9DFU2-2 ]
UniGenei At.26382.
At.48520.

3D structure databases

ProteinModelPortali B9DFU2.
SMRi B9DFU2. Positions 46-521.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B9DFU2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G26170.1 ; AT2G26170.1 ; AT2G26170 . [B9DFU2-1 ]
GeneIDi 817157.
KEGGi ath:AT2G26170.

Organism-specific databases

GeneFarmi 1383. 94.
TAIRi AT2G26170.

Phylogenomic databases

OMAi FITSATH.
PhylomeDBi B9DFU2.

Gene expression databases

ArrayExpressi B9DFU2.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "MAX1 encodes a cytochrome P450 family member that acts downstream of MAX3/4 to produce a carotenoid-derived branch-inhibiting hormone."
    Booker J., Sieberer T., Wright W., Williamson L., Willett B., Stirnberg P., Turnbull C., Srinivasan M., Goddard P., Leyser O.
    Dev. Cell 8:443-449(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis."
    Lazar G., Goodman H.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:472-476(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "Strigolactones enhance competition between shoot branches by dampening auxin transport."
    Crawford S., Shinohara N., Sieberer T., Williamson L., George G., Hepworth J., Mueller D., Domagalska M.A., Leyser O.
    Development 137:2905-2913(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  8. "Strigolactones are transported through the xylem and play a key role in shoot architectural response to phosphate deficiency in nonarbuscular mycorrhizal host Arabidopsis."
    Kohlen W., Charnikhova T., Liu Q., Bours R., Domagalska M.A., Beguerie S., Verstappen F., Leyser O., Bouwmeester H., Ruyter-Spira C.
    Plant Physiol. 155:974-987(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  9. "Selective mimics of strigolactone actions and their potential use for controlling damage caused by root parasitic weeds."
    Fukui K., Ito S., Asami T.
    Mol. Plant 6:88-99(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiMAX1_ARATH
AccessioniPrimary (citable) accession number: B9DFU2
Secondary accession number(s): O64853, Q940L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: May 3, 2011
Last modified: May 14, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The branching phenotypes of the max1, ccd7/max3 and ccd8/max4 mutants can be rescued by exogenous treatment with the synthetic strigolactone analogs GR24 and 4BD (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi