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Protein

PTI1-like tyrosine-protein kinase 3

Gene

PTI13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141ATPPROSITE-ProRule annotation1
Active sitei245Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi119 – 127ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-450302. activated TAK1 mediates p38 MAPK activation.
R-ATH-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Names & Taxonomyi

Protein namesi
Recommended name:
PTI1-like tyrosine-protein kinase 3 (EC:2.7.10.2)
Short name:
PTI1-3
Gene namesi
Name:PTI13
Ordered Locus Names:At3g59350
ORF Names:F25L23.210
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G59350.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004033241 – 408PTI1-like tyrosine-protein kinase 3Add BLAST408

Post-translational modificationi

Phosphorylated by OXI1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB9DFG5.

PTM databases

iPTMnetiB9DFG5.
SwissPalmiB9DFG5.

Expressioni

Gene expression databases

GenevisibleiB9DFG5. AT.

Interactioni

Subunit structurei

Interacts with OXI1.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi10419. 3 interactors.
IntActiB9DFG5. 2 interactors.
STRINGi3702.AT3G59350.1.

Structurei

3D structure databases

ProteinModelPortaliB9DFG5.
SMRiB9DFG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 395Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116550.
InParanoidiB9DFG5.
KOiK13436.
OMAiHVEEPYH.
OrthoDBiEOG09360DYR.
PhylomeDBiB9DFG5.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B9DFG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYPMDSDYHR RGLVANDRSP AQFVRLDKPR AVDDLYIGKR EKMRRWLCCA
60 70 80 90 100
CHVEEPYHSS ENEHLRSPKH HNDFGHHTRK PQAAVKPDAL KEPPSIDVPA
110 120 130 140 150
LSLDELKEKT DNFGSKSLIG EGSYGRAYYA TLKDGKAVAV KKLDNAAEPE
160 170 180 190 200
SNVEFLTQVS RVSKLKHDNF VELFGYCVEG NFRILAYEFA TMGSLHDILH
210 220 230 240 250
GRKGVQGAQP GPTLDWIQRV RIAVDAARGL EYLHEKVQPA VIHRDIRSSN
260 270 280 290 300
VLLFEDFKAK IADFNLSNQS PDMAARLHST RVLGTFGYHA PEYAMTGQLT
310 320 330 340 350
QKSDVYSFGV VLLELLTGRK PVDHTMPRGQ QSLVTWATPR LSEDKVKQCV
360 370 380 390 400
DPKLKGEYPP KAVAKLAAVA ALCVQYESEF RPNMSIVVKA LQPLLRSSTA

AAVPVQEA
Length:408
Mass (Da):45,658
Last modified:March 24, 2009 - v1
Checksum:i57AF0E1D1E5B0F8C
GO
Isoform 2 (identifier: B9DFG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:366
Mass (Da):40,695
Checksum:i74A99836337DCEF7
GO

Sequence cautioni

The sequence CAB91605 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0403691 – 42Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356014 Genomic DNA. Translation: CAB91605.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79908.1.
CP002686 Genomic DNA. Translation: AEE79909.1.
CP002686 Genomic DNA. Translation: AEE79910.1.
AY054639 mRNA. Translation: AAK96830.1.
BT008449 mRNA. Translation: AAP37808.1.
AK316761 mRNA. Translation: BAH19482.1.
AK317695 mRNA. Translation: BAH20354.1.
PIRiT49003.
RefSeqiNP_001030893.1. NM_001035816.1. [B9DFG5-1]
NP_567082.2. NM_115797.6. [B9DFG5-1]
NP_850720.1. NM_180389.3. [B9DFG5-2]
UniGeneiAt.1517.

Genome annotation databases

EnsemblPlantsiAT3G59350.1; AT3G59350.1; AT3G59350. [B9DFG5-1]
AT3G59350.3; AT3G59350.3; AT3G59350. [B9DFG5-1]
GeneIDi825104.
GrameneiAT3G59350.1; AT3G59350.1; AT3G59350.
AT3G59350.3; AT3G59350.3; AT3G59350.
KEGGiath:AT3G59350.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC
Arabidopsis protein tyrosine kinases

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356014 Genomic DNA. Translation: CAB91605.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79908.1.
CP002686 Genomic DNA. Translation: AEE79909.1.
CP002686 Genomic DNA. Translation: AEE79910.1.
AY054639 mRNA. Translation: AAK96830.1.
BT008449 mRNA. Translation: AAP37808.1.
AK316761 mRNA. Translation: BAH19482.1.
AK317695 mRNA. Translation: BAH20354.1.
PIRiT49003.
RefSeqiNP_001030893.1. NM_001035816.1. [B9DFG5-1]
NP_567082.2. NM_115797.6. [B9DFG5-1]
NP_850720.1. NM_180389.3. [B9DFG5-2]
UniGeneiAt.1517.

3D structure databases

ProteinModelPortaliB9DFG5.
SMRiB9DFG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10419. 3 interactors.
IntActiB9DFG5. 2 interactors.
STRINGi3702.AT3G59350.1.

PTM databases

iPTMnetiB9DFG5.
SwissPalmiB9DFG5.

Proteomic databases

PaxDbiB9DFG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G59350.1; AT3G59350.1; AT3G59350. [B9DFG5-1]
AT3G59350.3; AT3G59350.3; AT3G59350. [B9DFG5-1]
GeneIDi825104.
GrameneiAT3G59350.1; AT3G59350.1; AT3G59350.
AT3G59350.3; AT3G59350.3; AT3G59350.
KEGGiath:AT3G59350.

Organism-specific databases

TAIRiAT3G59350.

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116550.
InParanoidiB9DFG5.
KOiK13436.
OMAiHVEEPYH.
OrthoDBiEOG09360DYR.
PhylomeDBiB9DFG5.

Enzyme and pathway databases

ReactomeiR-ATH-450302. activated TAK1 mediates p38 MAPK activation.
R-ATH-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Miscellaneous databases

PROiB9DFG5.

Gene expression databases

GenevisibleiB9DFG5. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTI13_ARATH
AccessioniPrimary (citable) accession number: B9DFG5
Secondary accession number(s): B9DHY7, Q940H1, Q9LX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.