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B9DFG5

- PTI13_ARATH

UniProt

B9DFG5 - PTI13_ARATH

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Protein

PTI1-like tyrosine-protein kinase 3

Gene

PTI13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411ATPPROSITE-ProRule annotation
Active sitei245 – 2451Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi119 – 1279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein kinase binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G59350-MONOMER.
ARA:GQT-2063-MONOMER.
ReactomeiREACT_231757. activated TAK1 mediates p38 MAPK activation.
REACT_261170. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Names & Taxonomyi

Protein namesi
Recommended name:
PTI1-like tyrosine-protein kinase 3 (EC:2.7.10.2)
Short name:
PTI1-3
Gene namesi
Name:PTI13
Ordered Locus Names:At3g59350
ORF Names:F25L23.210
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G59350.

Subcellular locationi

Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408PTI1-like tyrosine-protein kinase 3PRO_0000403324Add
BLAST

Post-translational modificationi

Phosphorylated by OXI1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB9DFG5.
PRIDEiB9DFG5.

Expressioni

Gene expression databases

GenevestigatoriB9DFG5.

Interactioni

Subunit structurei

Interacts with OXI1.1 Publication

Protein-protein interaction databases

BioGridi10419. 3 interactions.
IntActiB9DFG5. 2 interactions.
STRINGi3702.AT3G59350.1-P.

Structurei

3D structure databases

ProteinModelPortaliB9DFG5.
SMRiB9DFG5. Positions 76-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 395283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116550.
InParanoidiB9DFG5.
OMAiKLKHDNF.
PhylomeDBiB9DFG5.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B9DFG5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYPMDSDYHR RGLVANDRSP AQFVRLDKPR AVDDLYIGKR EKMRRWLCCA
60 70 80 90 100
CHVEEPYHSS ENEHLRSPKH HNDFGHHTRK PQAAVKPDAL KEPPSIDVPA
110 120 130 140 150
LSLDELKEKT DNFGSKSLIG EGSYGRAYYA TLKDGKAVAV KKLDNAAEPE
160 170 180 190 200
SNVEFLTQVS RVSKLKHDNF VELFGYCVEG NFRILAYEFA TMGSLHDILH
210 220 230 240 250
GRKGVQGAQP GPTLDWIQRV RIAVDAARGL EYLHEKVQPA VIHRDIRSSN
260 270 280 290 300
VLLFEDFKAK IADFNLSNQS PDMAARLHST RVLGTFGYHA PEYAMTGQLT
310 320 330 340 350
QKSDVYSFGV VLLELLTGRK PVDHTMPRGQ QSLVTWATPR LSEDKVKQCV
360 370 380 390 400
DPKLKGEYPP KAVAKLAAVA ALCVQYESEF RPNMSIVVKA LQPLLRSSTA

AAVPVQEA
Length:408
Mass (Da):45,658
Last modified:March 24, 2009 - v1
Checksum:i57AF0E1D1E5B0F8C
GO
Isoform 2 (identifier: B9DFG5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:366
Mass (Da):40,695
Checksum:i74A99836337DCEF7
GO

Sequence cautioni

The sequence CAB91605.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_040369Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356014 Genomic DNA. Translation: CAB91605.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79908.1.
CP002686 Genomic DNA. Translation: AEE79909.1.
CP002686 Genomic DNA. Translation: AEE79910.1.
AY054639 mRNA. Translation: AAK96830.1.
BT008449 mRNA. Translation: AAP37808.1.
AK316761 mRNA. Translation: BAH19482.1.
AK317695 mRNA. Translation: BAH20354.1.
PIRiT49003.
RefSeqiNP_001030893.1. NM_001035816.1. [B9DFG5-1]
NP_567082.2. NM_115797.5. [B9DFG5-1]
NP_850720.1. NM_180389.2. [B9DFG5-2]
UniGeneiAt.1517.

Genome annotation databases

EnsemblPlantsiAT3G59350.1; AT3G59350.1; AT3G59350. [B9DFG5-1]
AT3G59350.3; AT3G59350.3; AT3G59350. [B9DFG5-1]
GeneIDi825104.
KEGGiath:AT3G59350.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC
Arabidopsis protein tyrosine kinases

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356014 Genomic DNA. Translation: CAB91605.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE79908.1 .
CP002686 Genomic DNA. Translation: AEE79909.1 .
CP002686 Genomic DNA. Translation: AEE79910.1 .
AY054639 mRNA. Translation: AAK96830.1 .
BT008449 mRNA. Translation: AAP37808.1 .
AK316761 mRNA. Translation: BAH19482.1 .
AK317695 mRNA. Translation: BAH20354.1 .
PIRi T49003.
RefSeqi NP_001030893.1. NM_001035816.1. [B9DFG5-1 ]
NP_567082.2. NM_115797.5. [B9DFG5-1 ]
NP_850720.1. NM_180389.2. [B9DFG5-2 ]
UniGenei At.1517.

3D structure databases

ProteinModelPortali B9DFG5.
SMRi B9DFG5. Positions 76-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 10419. 3 interactions.
IntActi B9DFG5. 2 interactions.
STRINGi 3702.AT3G59350.1-P.

Proteomic databases

PaxDbi B9DFG5.
PRIDEi B9DFG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G59350.1 ; AT3G59350.1 ; AT3G59350 . [B9DFG5-1 ]
AT3G59350.3 ; AT3G59350.3 ; AT3G59350 . [B9DFG5-1 ]
GeneIDi 825104.
KEGGi ath:AT3G59350.

Organism-specific databases

GeneFarmi 1786. 139.
TAIRi AT3G59350.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000116550.
InParanoidi B9DFG5.
OMAi KLKHDNF.
PhylomeDBi B9DFG5.

Enzyme and pathway databases

BioCyci ARA:AT3G59350-MONOMER.
ARA:GQT-2063-MONOMER.
Reactomei REACT_231757. activated TAK1 mediates p38 MAPK activation.
REACT_261170. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Gene expression databases

Genevestigatori B9DFG5.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "The Arabidopsis protein kinase PTI1-2 is activated by convergent phosphatidic acid and oxidative stress signaling pathways downstream of PDK1 and OXI1."
    Anthony R.G., Khan S., Costa J., Pais M.S., Boegre L.
    J. Biol. Chem. 281:37536-37546(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OXI1, PHOSPHORYLATION BY OXI1.
  6. "A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome."
    Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J., Barbier-Brygoo H., Ephritikhine G.
    Mol. Cell. Proteomics 6:1980-1996(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTI13_ARATH
AccessioniPrimary (citable) accession number: B9DFG5
Secondary accession number(s): B9DHY7, Q940H1, Q9LX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 24, 2009
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3