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B9DFG5

- PTI13_ARATH

UniProt

B9DFG5 - PTI13_ARATH

Protein

PTI1-like tyrosine-protein kinase 3

Gene

PTI13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei141 – 1411ATPPROSITE-ProRule annotation
    Active sitei245 – 2451Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi119 – 1279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    3. protein kinase binding Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G59350-MONOMER.
    ARA:GQT-2063-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PTI1-like tyrosine-protein kinase 3 (EC:2.7.10.2)
    Short name:
    PTI1-3
    Gene namesi
    Name:PTI13
    Ordered Locus Names:At3g59350
    ORF Names:F25L23.210
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G59350.

    Subcellular locationi

    Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408PTI1-like tyrosine-protein kinase 3PRO_0000403324Add
    BLAST

    Post-translational modificationi

    Phosphorylated by OXI1.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiB9DFG5.
    PRIDEiB9DFG5.

    Expressioni

    Gene expression databases

    GenevestigatoriB9DFG5.

    Interactioni

    Subunit structurei

    Interacts with OXI1.1 Publication

    Protein-protein interaction databases

    BioGridi10419. 3 interactions.
    IntActiB9DFG5. 2 interactions.
    STRINGi3702.AT3G59350.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliB9DFG5.
    SMRiB9DFG5. Positions 94-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini113 – 395283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000116550.
    InParanoidiQ9LX36.
    OMAiKLKHDNF.
    PhylomeDBiB9DFG5.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B9DFG5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYPMDSDYHR RGLVANDRSP AQFVRLDKPR AVDDLYIGKR EKMRRWLCCA    50
    CHVEEPYHSS ENEHLRSPKH HNDFGHHTRK PQAAVKPDAL KEPPSIDVPA 100
    LSLDELKEKT DNFGSKSLIG EGSYGRAYYA TLKDGKAVAV KKLDNAAEPE 150
    SNVEFLTQVS RVSKLKHDNF VELFGYCVEG NFRILAYEFA TMGSLHDILH 200
    GRKGVQGAQP GPTLDWIQRV RIAVDAARGL EYLHEKVQPA VIHRDIRSSN 250
    VLLFEDFKAK IADFNLSNQS PDMAARLHST RVLGTFGYHA PEYAMTGQLT 300
    QKSDVYSFGV VLLELLTGRK PVDHTMPRGQ QSLVTWATPR LSEDKVKQCV 350
    DPKLKGEYPP KAVAKLAAVA ALCVQYESEF RPNMSIVVKA LQPLLRSSTA 400
    AAVPVQEA 408
    Length:408
    Mass (Da):45,658
    Last modified:March 24, 2009 - v1
    Checksum:i57AF0E1D1E5B0F8C
    GO
    Isoform 2 (identifier: B9DFG5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.

    Show »
    Length:366
    Mass (Da):40,695
    Checksum:i74A99836337DCEF7
    GO

    Sequence cautioni

    The sequence CAB91605.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_040369Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356014 Genomic DNA. Translation: CAB91605.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE79908.1.
    CP002686 Genomic DNA. Translation: AEE79909.1.
    CP002686 Genomic DNA. Translation: AEE79910.1.
    AY054639 mRNA. Translation: AAK96830.1.
    BT008449 mRNA. Translation: AAP37808.1.
    AK316761 mRNA. Translation: BAH19482.1.
    AK317695 mRNA. Translation: BAH20354.1.
    PIRiT49003.
    RefSeqiNP_001030893.1. NM_001035816.1. [B9DFG5-1]
    NP_567082.2. NM_115797.5. [B9DFG5-1]
    NP_850720.1. NM_180389.2. [B9DFG5-2]
    UniGeneiAt.1517.

    Genome annotation databases

    EnsemblPlantsiAT3G59350.1; AT3G59350.1; AT3G59350. [B9DFG5-1]
    AT3G59350.3; AT3G59350.3; AT3G59350. [B9DFG5-1]
    GeneIDi825104.
    KEGGiath:AT3G59350.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC
    Arabidopsis protein tyrosine kinases

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356014 Genomic DNA. Translation: CAB91605.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE79908.1 .
    CP002686 Genomic DNA. Translation: AEE79909.1 .
    CP002686 Genomic DNA. Translation: AEE79910.1 .
    AY054639 mRNA. Translation: AAK96830.1 .
    BT008449 mRNA. Translation: AAP37808.1 .
    AK316761 mRNA. Translation: BAH19482.1 .
    AK317695 mRNA. Translation: BAH20354.1 .
    PIRi T49003.
    RefSeqi NP_001030893.1. NM_001035816.1. [B9DFG5-1 ]
    NP_567082.2. NM_115797.5. [B9DFG5-1 ]
    NP_850720.1. NM_180389.2. [B9DFG5-2 ]
    UniGenei At.1517.

    3D structure databases

    ProteinModelPortali B9DFG5.
    SMRi B9DFG5. Positions 94-396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 10419. 3 interactions.
    IntActi B9DFG5. 2 interactions.
    STRINGi 3702.AT3G59350.1-P.

    Proteomic databases

    PaxDbi B9DFG5.
    PRIDEi B9DFG5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G59350.1 ; AT3G59350.1 ; AT3G59350 . [B9DFG5-1 ]
    AT3G59350.3 ; AT3G59350.3 ; AT3G59350 . [B9DFG5-1 ]
    GeneIDi 825104.
    KEGGi ath:AT3G59350.

    Organism-specific databases

    GeneFarmi 1786. 139.
    TAIRi AT3G59350.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000116550.
    InParanoidi Q9LX36.
    OMAi KLKHDNF.
    PhylomeDBi B9DFG5.

    Enzyme and pathway databases

    BioCyci ARA:AT3G59350-MONOMER.
    ARA:GQT-2063-MONOMER.

    Gene expression databases

    Genevestigatori B9DFG5.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
      Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
      DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. "The Arabidopsis protein kinase PTI1-2 is activated by convergent phosphatidic acid and oxidative stress signaling pathways downstream of PDK1 and OXI1."
      Anthony R.G., Khan S., Costa J., Pais M.S., Boegre L.
      J. Biol. Chem. 281:37536-37546(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH OXI1, PHOSPHORYLATION BY OXI1.
    6. "A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome."
      Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J., Barbier-Brygoo H., Ephritikhine G.
      Mol. Cell. Proteomics 6:1980-1996(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTI13_ARATH
    AccessioniPrimary (citable) accession number: B9DFG5
    Secondary accession number(s): B9DHY7, Q940H1, Q9LX36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3