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Protein
Submitted name:

TBC1 domain family, member 5

Gene

TBC1D5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
TBC1 domain family, member 5Imported
Gene namesi
Name:TBC1D5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38808.

PTM / Processingi

Proteomic databases

PaxDbiB9A6K1.
PRIDEiB9A6K1.

Expressioni

Gene expression databases

BgeeiB9A6K1.
ExpressionAtlasiB9A6K1. baseline and differential.
GenevisibleiB9A6K1. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF1ADQ8N9N83EBI-10217641,EBI-750700
GABARAPL1Q9H0R83EBI-10217641,EBI-3464833
GABARAPL2P605203EBI-10217641,EBI-720116
VPS29Q9UBQ03EBI-10217641,EBI-718596

Protein-protein interaction databases

IntActiB9A6K1. 4 interactions.
STRINGi9606.ENSP00000402935.

Structurei

3D structure databases

ProteinModelPortaliB9A6K1.
SMRiB9A6K1. Positions 163-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 359279Rab-GAP TBCInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1091. Eukaryota.
ENOG410YX8Z. LUCA.
HOVERGENiHBG062913.
PhylomeDBiB9A6K1.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 3 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9A6K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHSLSETRH PLQPEEQEVG IDPLSSYSNK SGGDSNKNGR RTSSTLDSEG
60 70 80 90 100
TFNSYRKEWE ELFVNNNYLA TIRQKGINGQ LRSSRFRSIC WKLFLCVLPQ
110 120 130 140 150
DKSQWISRIE ELRAWYSNIK EIHITNPRKV VGQQDLMINN PLSQDEGSLW
160 170 180 190 200
NKFFQDKELR SMIEQDVKRT FPEMQFFQQE NVRKILTDVL FCYARENEQL
210 220 230 240 250
LYKQGMHELL APIVFVLHCD HQAFLHASES AQPSEEMKTV LNPEYLEHDA
260 270 280 290 300
YAVFSQLMET AEPWFSTFEH DGQKGKETLM TPIPFARPQD LGPTIAIVTK
310 320 330 340 350
VNQIQDHLLK KHDIELYMHL NRLEIAPQIY GLRWVRLLFG REFPLQDLLV
360 370 380 390 400
VWDALFADGL SLGLVDYIFV AMLLYIRDAL ISSNYQTCLG LLMHYPFIGD
410 420 430 440 450
VHSLILKALF LRDPKRNPRP VTYQFHPNLD YYKARGADLM NKSRTNAKGA
460 470 480 490 500
PLNINKVSNS LINFGRKLIS PAMAPGSAGG PVPGGNSSSS SSVVIPTRTS
510 520 530 540 550
AEAPSHHLQQ QQQQQRLMKS ESMPVQLNKG LSSKNISSSP SVESLPGGRE
560 570 580 590 600
FTGSPPSSAT KKDSFFSNIS RSRSHSKTMG RKESEEELEA QISFLQGQLN
610 620 630 640 650
DLDAMCKYCA KVMDTHLVNI QDVILQENLE KEDQILVSLA GLKQIKDILK
660 670 680 690 700
GSLRFNQSQL EAEENEQITI ADNHYCSSGQ GQGRGQGQSV QMSGAIKQAS
710 720 730 740 750
SETPGCTDRG NSDDFILISK DDDGSSARGS FSGQAQPLRT LRSTSGKSQA
760 770 780 790
PVCSPLVFSD PLMGPASASS SNPSSSPDDD SSKDSGFTIV SPLDI
Length:795
Mass (Da):89,004
Last modified:March 24, 2009 - v1
Checksum:i598CE3B436835E1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449886 mRNA. Translation: BAH16629.1.
RefSeqiNP_055559.1. NM_014744.2.
XP_005265671.1. XM_005265614.1.
UniGeneiHs.475629.

Genome annotation databases

GeneIDi9779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449886 mRNA. Translation: BAH16629.1.
RefSeqiNP_055559.1. NM_014744.2.
XP_005265671.1. XM_005265614.1.
UniGeneiHs.475629.

3D structure databases

ProteinModelPortaliB9A6K1.
SMRiB9A6K1. Positions 163-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB9A6K1. 4 interactions.
STRINGi9606.ENSP00000402935.

Proteomic databases

PaxDbiB9A6K1.
PRIDEiB9A6K1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9779.

Organism-specific databases

CTDi9779.
PharmGKBiPA38808.

Phylogenomic databases

eggNOGiKOG1091. Eukaryota.
ENOG410YX8Z. LUCA.
HOVERGENiHBG062913.
PhylomeDBiB9A6K1.

Miscellaneous databases

ChiTaRSiTBC1D5. human.
GenomeRNAii9779.

Gene expression databases

BgeeiB9A6K1.
ExpressionAtlasiB9A6K1. baseline and differential.
GenevisibleiB9A6K1. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 3 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."
    Ishibashi K., Kanno E., Itoh T., Fukuda M.
    Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiB9A6K1_HUMAN
AccessioniPrimary (citable) accession number: B9A6K1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: June 8, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.