IMMT

Functionⁱ

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.UniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MICOS complex subunit MIC60UniRule annotation Automatic assertion according to rulesⁱ RuleBase:RU363000 Alternative name(s): MitofilinUniRule annotation Automatic assertion according to rulesⁱ RuleBase:RU363000
Gene namesⁱ	Name:IMMTImported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000387227
Organismⁱ	Homo sapiens (Human)Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000387227 Proteomes:UP000005640
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

HGNCⁱ

HGNC:6047. IMMT.

Subcellular locationⁱ

Mitochondrion inner membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU363000
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00545102
; Single-pass membrane protein
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU363000
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00545102

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
mitochondrial inner membrane Source: UniProtKB-SubCell
mitochondrion Source: HPA

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PeptideAtlasⁱ	B9A067.
PRIDEⁱ	B9A067.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000132305.
ExpressionAtlasⁱ	B9A067. baseline and differential.

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.UniRule annotationSAAS annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B9A067.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Coiled coilⁱ	234 – 268	35	Sequence analysis Automatic assertion according to rulesⁱ SAM:Coils			Add BLAST
Coiled coilⁱ	351 – 378	28	Sequence analysis Automatic assertion according to rulesⁱ SAM:Coils			Add BLAST

Sequence similaritiesⁱ

Belongs to the MICOS complex subunit Mic60 family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000002313.
HOVERGENⁱ	HBG039233.

Family and domain databases

InterProⁱ	IPR019133. Mt-IM_prot_Mitofilin. [Graphical view]
Pfamⁱ	PF09731. Mitofilin. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

B9A067-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG 
        60         70         80         90        100
LLFVGGGIGG TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP 
       110        120        130        140        150
KKSIQSGPLK ISSVSEVMKE SKQPASQLQK QKGDTPASAT EASSSSIRER 
       160        170        180        190        200
PPEEVAARLA QQEKQEQVKI ESLAKSLEDA LRQTASVTLQ AIAAQNAAVQ 
       210        220        230        240        250
AVNAHSNILK AAMDNSEIAG EKKSAQWRTV EGALKERRKA VDEAADALLK 
       260        270        280        290        300
AKEELEKMKS VIENAKKKEV AGAKPHITAA EGKLHNMIVD LDNVVKKVQA 
       310        320        330        340        350
AQSEAKVVSQ YHELVVQARD DFKRELDSIT PEVLPGWKGM SVSDLADKLS 
       360        370        380        390        400
TDDLNSLIAH AHRRIDQLNR ELAEQKATEK QHITLALEKQ KLEEKRAFDS 
       410        420        430        440        450
AVAKALEHHR SEIQAEQDRK IEEVRDAMEN EMRTQLRRQA AAHTDHLRDV 
       460        470        480        490        500
LRVQEQELKS EFEQNLSEKL SEQELQFRRL SQEQVDNFTL DINTAYARLR 
       510        520        530        540        550
GIEQAVQSHA VAEEEARKAH QLWLSVEALK YSMKTSSAET PTIPLGSAVE 
       560        570        580        590        600
AIKANCSDNE FTQALTAAIP PESLTRGVYS EETLRARFYA VQKLARRVAM 
       610        620        630        640        650
IDETRNSLYQ YFLSYLQSLL LFPPQQLKPP PELCPEDINT FKLLSYASYC 
       660        670        680        690        700
IEHGDLELAA KFVNQLKGES RRVAQDWLKE ARMTLETKQI VEILTAYASA 
       710 
VGIGTTQVQP E

Length:711

Mass (Da):78,974

Last modified:November 3, 2009 - v2

Checksum:ⁱ45565F6877D08C0B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC009309 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC009309 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000409051; ENSP00000387227; ENSG00000132305.
UCSCⁱ	uc010yte.3. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC009309 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC009309 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	B9A067.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	B9A067.
PRIDEⁱ	B9A067.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000409051; ENSP00000387227; ENSG00000132305.
UCSCⁱ	uc010yte.3. human.

Organism-specific databases

HGNCⁱ	HGNC:6047. IMMT.
GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000002313.
HOVERGENⁱ	HBG039233.

Miscellaneous databases

ChiTaRSⁱ	IMMT. human.

ChiTaRSⁱ

IMMT. human.

Gene expression databases

Bgeeⁱ	ENSG00000132305.
ExpressionAtlasⁱ	B9A067. baseline and differential.

Family and domain databases

InterProⁱ	IPR019133. Mt-IM_prot_Mitofilin. [Graphical view]
Pfamⁱ	PF09731. Mitofilin. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

B9A067_HUMAN

Accessionⁱ

Primary (citable) accession number: B9A067

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	November 3, 2009
Last modified:	September 7, 2016
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B9A067 (B9A067_HUMAN)

UniProt

B9A067 - B9A067_HUMAN

Your basket is currently empty.

MICOS complex subunit MIC60

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ