UniProtKB - B9A067 (B9A067_HUMAN)
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Protein
MICOS complex subunit MIC60
Gene
IMMT
Organism
Homo sapiens (Human)
Status
Functioni
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.UniRule annotation
Names & Taxonomyi
Protein namesi | Recommended name: MICOS complex subunit MIC60UniRule annotationAlternative name(s): MitofilinUniRule annotation |
Gene namesi | Name:IMMTImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000132305.20 |
HGNCi | HGNC:6047 IMMT |
Subcellular locationi
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotationExpressioni
Gene expression databases
Bgeei | ENSG00000132305 |
ExpressionAtlasi | B9A067 baseline and differential |
Interactioni
Subunit structurei
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.UniRule annotationSAAS annotation
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 160 – 180 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 234 – 268 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 351 – 378 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 463 – 483 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSAAS annotationPhylogenomic databases
GeneTreei | ENSGT00390000002313 |
HOVERGENi | HBG039233 |
Family and domain databases
InterProi | View protein in InterPro IPR019133 Mt-IM_prot_Mitofilin |
PANTHERi | PTHR15415 PTHR15415, 1 hit |
Pfami | View protein in Pfam PF09731 Mitofilin, 1 hit |
i Sequence
Sequence statusi: Complete.
B9A067-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG
60 70 80 90 100
LLFVGGGIGG TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP
110 120 130 140 150
KKSIQSGPLK ISSVSEVMKE SKQPASQLQK QKGDTPASAT EASSSSIRER
160 170 180 190 200
PPEEVAARLA QQEKQEQVKI ESLAKSLEDA LRQTASVTLQ AIAAQNAAVQ
210 220 230 240 250
AVNAHSNILK AAMDNSEIAG EKKSAQWRTV EGALKERRKA VDEAADALLK
260 270 280 290 300
AKEELEKMKS VIENAKKKEV AGAKPHITAA EGKLHNMIVD LDNVVKKVQA
310 320 330 340 350
AQSEAKVVSQ YHELVVQARD DFKRELDSIT PEVLPGWKGM SVSDLADKLS
360 370 380 390 400
TDDLNSLIAH AHRRIDQLNR ELAEQKATEK QHITLALEKQ KLEEKRAFDS
410 420 430 440 450
AVAKALEHHR SEIQAEQDRK IEEVRDAMEN EMRTQLRRQA AAHTDHLRDV
460 470 480 490 500
LRVQEQELKS EFEQNLSEKL SEQELQFRRL SQEQVDNFTL DINTAYARLR
510 520 530 540 550
GIEQAVQSHA VAEEEARKAH QLWLSVEALK YSMKTSSAET PTIPLGSAVE
560 570 580 590 600
AIKANCSDNE FTQALTAAIP PESLTRGVYS EETLRARFYA VQKLARRVAM
610 620 630 640 650
IDETRNSLYQ YFLSYLQSLL LFPPQQLKPP PELCPEDINT FKLLSYASYC
660 670 680 690 700
IEHGDLELAA KFVNQLKGES RRVAQDWLKE ARMTLETKQI VEILTAYASA
710
VGIGTTQVQP E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009309 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000409051; ENSP00000387227; ENSG00000132305 |
UCSCi | uc010yte.3 human |
Similar proteinsi
Entry informationi
Entry namei | B9A067_HUMAN | |
Accessioni | B9A067Primary (citable) accession number: B9A067 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | March 28, 2018 | |
This is version 65 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |