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Protein

MICOS complex subunit MIC60

Gene

IMMT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.UniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC60UniRule annotation
Alternative name(s):
MitofilinUniRule annotation
Gene namesi
Name:IMMTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6047. IMMT.

Subcellular locationi

  • Mitochondrion SAAS annotation
  • Mitochondrion inner membrane UniRule annotationSAAS annotation; Single-pass membrane protein UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

EPDiB9A067.
PRIDEiB9A067.

Expressioni

Gene expression databases

BgeeiB9A067.
ExpressionAtlasiB9A067. baseline and differential.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB9A067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili234 – 26835Sequence analysisAdd
BLAST
Coiled coili351 – 37828Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic60 family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000002313.
HOVERGENiHBG039233.
OrthoDBiEOG744TB6.

Family and domain databases

InterProiIPR019133. Mt-IM_prot_Mitofilin.
[Graphical view]
PfamiPF09731. Mitofilin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9A067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG
60 70 80 90 100
LLFVGGGIGG TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP
110 120 130 140 150
KKSIQSGPLK ISSVSEVMKE SKQPASQLQK QKGDTPASAT EASSSSIRER
160 170 180 190 200
PPEEVAARLA QQEKQEQVKI ESLAKSLEDA LRQTASVTLQ AIAAQNAAVQ
210 220 230 240 250
AVNAHSNILK AAMDNSEIAG EKKSAQWRTV EGALKERRKA VDEAADALLK
260 270 280 290 300
AKEELEKMKS VIENAKKKEV AGAKPHITAA EGKLHNMIVD LDNVVKKVQA
310 320 330 340 350
AQSEAKVVSQ YHELVVQARD DFKRELDSIT PEVLPGWKGM SVSDLADKLS
360 370 380 390 400
TDDLNSLIAH AHRRIDQLNR ELAEQKATEK QHITLALEKQ KLEEKRAFDS
410 420 430 440 450
AVAKALEHHR SEIQAEQDRK IEEVRDAMEN EMRTQLRRQA AAHTDHLRDV
460 470 480 490 500
LRVQEQELKS EFEQNLSEKL SEQELQFRRL SQEQVDNFTL DINTAYARLR
510 520 530 540 550
GIEQAVQSHA VAEEEARKAH QLWLSVEALK YSMKTSSAET PTIPLGSAVE
560 570 580 590 600
AIKANCSDNE FTQALTAAIP PESLTRGVYS EETLRARFYA VQKLARRVAM
610 620 630 640 650
IDETRNSLYQ YFLSYLQSLL LFPPQQLKPP PELCPEDINT FKLLSYASYC
660 670 680 690 700
IEHGDLELAA KFVNQLKGES RRVAQDWLKE ARMTLETKQI VEILTAYASA
710
VGIGTTQVQP E
Length:711
Mass (Da):78,974
Last modified:November 3, 2009 - v2
Checksum:i45565F6877D08C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009309 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000409051; ENSP00000387227; ENSG00000132305.
UCSCiuc010yte.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009309 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB9A067.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiB9A067.
PRIDEiB9A067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409051; ENSP00000387227; ENSG00000132305.
UCSCiuc010yte.3. human.

Organism-specific databases

HGNCiHGNC:6047. IMMT.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000002313.
HOVERGENiHBG039233.
OrthoDBiEOG744TB6.

Miscellaneous databases

ChiTaRSiIMMT. human.

Gene expression databases

BgeeiB9A067.
ExpressionAtlasiB9A067. baseline and differential.

Family and domain databases

InterProiIPR019133. Mt-IM_prot_Mitofilin.
[Graphical view]
PfamiPF09731. Mitofilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "N-terminome analysis of the human mitochondrial proteome."
    Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.
    Proteomics 15:2519-2524(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiB9A067_HUMAN
AccessioniPrimary (citable) accession number: B9A067
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: November 3, 2009
Last modified: June 8, 2016
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.