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Protein

MICOS complex subunit MIC60

Gene

IMMT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC60UniRule annotation
Alternative name(s):
MitofilinUniRule annotation
Gene namesi
Name:IMMTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000132305.20
HGNCiHGNC:6047 IMMT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132305

PTM / Processingi

Proteomic databases

MaxQBiB9A067
PeptideAtlasiB9A067
PRIDEiB9A067

Expressioni

Gene expression databases

BgeeiENSG00000132305
ExpressionAtlasiB9A067 baseline and differential

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB9A067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili160 – 180Sequence analysisAdd BLAST21
Coiled coili234 – 268Sequence analysisAdd BLAST35
Coiled coili351 – 378Sequence analysisAdd BLAST28
Coiled coili463 – 483Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic60 family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000002313
HOVERGENiHBG039233

Family and domain databases

InterProiView protein in InterPro
IPR019133 Mt-IM_prot_Mitofilin
PANTHERiPTHR15415 PTHR15415, 1 hit
PfamiView protein in Pfam
PF09731 Mitofilin, 1 hit

Sequencei

Sequence statusi: Complete.

B9A067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG
60 70 80 90 100
LLFVGGGIGG TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP
110 120 130 140 150
KKSIQSGPLK ISSVSEVMKE SKQPASQLQK QKGDTPASAT EASSSSIRER
160 170 180 190 200
PPEEVAARLA QQEKQEQVKI ESLAKSLEDA LRQTASVTLQ AIAAQNAAVQ
210 220 230 240 250
AVNAHSNILK AAMDNSEIAG EKKSAQWRTV EGALKERRKA VDEAADALLK
260 270 280 290 300
AKEELEKMKS VIENAKKKEV AGAKPHITAA EGKLHNMIVD LDNVVKKVQA
310 320 330 340 350
AQSEAKVVSQ YHELVVQARD DFKRELDSIT PEVLPGWKGM SVSDLADKLS
360 370 380 390 400
TDDLNSLIAH AHRRIDQLNR ELAEQKATEK QHITLALEKQ KLEEKRAFDS
410 420 430 440 450
AVAKALEHHR SEIQAEQDRK IEEVRDAMEN EMRTQLRRQA AAHTDHLRDV
460 470 480 490 500
LRVQEQELKS EFEQNLSEKL SEQELQFRRL SQEQVDNFTL DINTAYARLR
510 520 530 540 550
GIEQAVQSHA VAEEEARKAH QLWLSVEALK YSMKTSSAET PTIPLGSAVE
560 570 580 590 600
AIKANCSDNE FTQALTAAIP PESLTRGVYS EETLRARFYA VQKLARRVAM
610 620 630 640 650
IDETRNSLYQ YFLSYLQSLL LFPPQQLKPP PELCPEDINT FKLLSYASYC
660 670 680 690 700
IEHGDLELAA KFVNQLKGES RRVAQDWLKE ARMTLETKQI VEILTAYASA
710
VGIGTTQVQP E
Length:711
Mass (Da):78,974
Last modified:November 3, 2009 - v2
Checksum:i45565F6877D08C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009309 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000409051; ENSP00000387227; ENSG00000132305
UCSCiuc010yte.3 human

Similar proteinsi

Entry informationi

Entry nameiB9A067_HUMAN
AccessioniPrimary (citable) accession number: B9A067
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: November 3, 2009
Last modified: March 28, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported