IMMT

Functionⁱ

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.UniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MICOS complex subunit MIC60UniRule annotation Alternative name(s): MitofilinUniRule annotation
Gene namesⁱ	Name:IMMTImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

HGNCⁱ

HGNC:6047. IMMT.

Subcellular locationⁱ

Mitochondrion inner membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU363000
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00545102
; Single-pass membrane protein
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU363000
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00545102

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
mitochondrial inner membrane Source: UniProtKB-SubCell
mitochondrion Source: HPA

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000132305.

OpenTargetsⁱ

ENSG00000132305.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B9A067.
PeptideAtlas More...PeptideAtlasⁱ	B9A067.
PRIDEⁱ	B9A067.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000132305.
ExpressionAtlasⁱ	B9A067. baseline and differential.

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.UniRule annotationSAAS annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B9A067.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	234 – 268	Sequence analysisAdd BLAST		35
Coiled coilⁱ	351 – 378	Sequence analysisAdd BLAST		28

Sequence similaritiesⁱ

Belongs to the MICOS complex subunit Mic60 family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002313.
HOVERGENⁱ	HBG039233.

Family and domain databases

InterProⁱ	View protein in InterPro IPR019133. Mt-IM_prot_Mitofilin.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09731. Mitofilin. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B9A067-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG 
        60         70         80         90        100
LLFVGGGIGG TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP 
       110        120        130        140        150
KKSIQSGPLK ISSVSEVMKE SKQPASQLQK QKGDTPASAT EASSSSIRER 
       160        170        180        190        200
PPEEVAARLA QQEKQEQVKI ESLAKSLEDA LRQTASVTLQ AIAAQNAAVQ 
       210        220        230        240        250
AVNAHSNILK AAMDNSEIAG EKKSAQWRTV EGALKERRKA VDEAADALLK 
       260        270        280        290        300
AKEELEKMKS VIENAKKKEV AGAKPHITAA EGKLHNMIVD LDNVVKKVQA 
       310        320        330        340        350
AQSEAKVVSQ YHELVVQARD DFKRELDSIT PEVLPGWKGM SVSDLADKLS 
       360        370        380        390        400
TDDLNSLIAH AHRRIDQLNR ELAEQKATEK QHITLALEKQ KLEEKRAFDS 
       410        420        430        440        450
AVAKALEHHR SEIQAEQDRK IEEVRDAMEN EMRTQLRRQA AAHTDHLRDV 
       460        470        480        490        500
LRVQEQELKS EFEQNLSEKL SEQELQFRRL SQEQVDNFTL DINTAYARLR 
       510        520        530        540        550
GIEQAVQSHA VAEEEARKAH QLWLSVEALK YSMKTSSAET PTIPLGSAVE 
       560        570        580        590        600
AIKANCSDNE FTQALTAAIP PESLTRGVYS EETLRARFYA VQKLARRVAM 
       610        620        630        640        650
IDETRNSLYQ YFLSYLQSLL LFPPQQLKPP PELCPEDINT FKLLSYASYC 
       660        670        680        690        700
IEHGDLELAA KFVNQLKGES RRVAQDWLKE ARMTLETKQI VEILTAYASA 
       710 
VGIGTTQVQP E

Length:711

Mass (Da):78,974

Last modified:November 3, 2009 - v2

Checksum:ⁱ45565F6877D08C0B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC009309 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC009309 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000409051; ENSP00000387227; ENSG00000132305.
UCSC genome browser More...UCSCⁱ	uc010yte.3. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC009309 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC009309 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	B9A067.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B9A067.
PeptideAtlas More...PeptideAtlasⁱ	B9A067.
PRIDEⁱ	B9A067.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000409051; ENSP00000387227; ENSG00000132305.
UCSC genome browser More...UCSCⁱ	uc010yte.3. human.

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6047. IMMT.
Open Targets More...OpenTargetsⁱ	ENSG00000132305.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002313.
HOVERGENⁱ	HBG039233.

Miscellaneous databases

ChiTaRSⁱ	IMMT. human.

ChiTaRSⁱ

IMMT. human.

Gene expression databases

Bgeeⁱ	ENSG00000132305.
ExpressionAtlasⁱ	B9A067. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR019133. Mt-IM_prot_Mitofilin.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09731. Mitofilin. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B9A067_HUMAN
Accessionⁱ	B9A067Primary (citable) accession number: B9A067
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 3, 2009
	Last sequence update:	November 3, 2009
	Last modified:	January 18, 2017
	This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B9A067 (B9A067_HUMAN)

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MICOS complex subunit MIC60

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ