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B9A064 (IGLL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin lambda-like polypeptide 5
Alternative name(s):
G lambda-1
Germline immunoglobulin lambda 1
Gene names
Name:IGLL5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Tissue specificity

Contrary to IGLL1, not expressed in pre-B-cells. Ref.1 Ref.2

Miscellaneous

Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression.

Sequence similarities

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin domain
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B9A064-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: B9A064-2)

The sequence of this isoform differs from the canonical sequence as follows:
     70-84: LLLQPSPQRADPRCW → SAQGQPHCHSVPALL
     85-214: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 214179Immunoglobulin lambda-like polypeptide 5
PRO_0000405596

Regions

Domain115 – 20995Ig-like C1-type
Region98 – 10912J region (By similarity to lambda light-chain)
Region110 – 214105C region (By similarity to lambda light-chain)

Amino acid modifications

Disulfide bond136 ↔ 195 By similarity

Natural variations

Alternative sequence70 – 8415LLLQP…DPRCW → SAQGQPHCHSVPALL in isoform 2.
VSP_040709
Alternative sequence85 – 214130Missing in isoform 2.
VSP_040710

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 8, 2011. Version 2.
Checksum: A29B29F09C063EBC

FASTA21423,063
        10         20         30         40         50         60 
MRPKTGQVGC ETPEELGPGP RQRWPLLLLG LAMVAHGLLR PMVAPQSGDP DPGASVGSSR 

        70         80         90        100        110        120 
SSLRSLWGRL LLQPSPQRAD PRCWPRGFWS EPQSLCYVFG TGTKVTVLGQ PKANPTVTLF 

       130        140        150        160        170        180 
PPSSEELQAN KATLVCLISD FYPGAVTVAW KADGSPVKAG VETTKPSKQS NNKYAASSYL 

       190        200        210 
SLTPEQWKSH RSYSCQVTHE GSTVEKTVAP TECS 

« Hide

Isoform 2 [UniParc].

Checksum: 668BAC17435C50E8
Show »

FASTA848,843

References

« Hide 'large scale' references
[1]"Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains."
Guglielmi P., Davi F.
Eur. J. Immunol. 21:501-508(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]"Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution."
Evans R.J., Hollis G.F.
J. Exp. Med. 173:305-311(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87023 Genomic DNA. No translation available.
RefSeqNP_001171597.1. NM_001178126.1.
UniGeneHs.449585.
Hs.625768.

3D structure databases

ProteinModelPortalB9A064.
SMRB9A064. Positions 40-214.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1148096. 2 interactions.

PTM databases

PhosphoSiteB9A064.

Proteomic databases

PaxDbB9A064.
PRIDEB9A064.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000526893; ENSP00000431254; ENSG00000254709. [B9A064-1]
ENST00000531372; ENSP00000434368; ENSG00000254709. [B9A064-2]
GeneID100423062.
KEGGhsa:100423062.
UCSCuc011aiw.2. human. [B9A064-1]

Organism-specific databases

CTD100423062.
GeneCardsGC22P023299.
HGNCHGNC:38476. IGLL5.
HPAHPA046779.
neXtProtNX_B9A064.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG76644.
HOVERGENHBG108319.
OrthoDBEOG7HTHJS.
PhylomeDBB9A064.
TreeFamTF335549.

Gene expression databases

BgeeB9A064.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio34053517.
PROB9A064.

Entry information

Entry nameIGLL5_HUMAN
AccessionPrimary (citable) accession number: B9A064
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM