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B9A064

- IGLL5_HUMAN

UniProt

B9A064 - IGLL5_HUMAN

Protein

Immunoglobulin lambda-like polypeptide 5

Gene

IGLL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 2 (08 Mar 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin lambda-like polypeptide 5
    Alternative name(s):
    G lambda-1
    Germline immunoglobulin lambda 1
    Gene namesi
    Name:IGLL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:38476. IGLL5.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 214179Immunoglobulin lambda-like polypeptide 5PRO_0000405596Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi136 ↔ 195PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiB9A064.
    PRIDEiB9A064.

    PTM databases

    PhosphoSiteiB9A064.

    Expressioni

    Tissue specificityi

    Contrary to IGLL1, not expressed in pre-B-cells.2 Publications

    Gene expression databases

    BgeeiB9A064.

    Organism-specific databases

    HPAiHPA046779.

    Interactioni

    Protein-protein interaction databases

    BioGridi1148096. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliB9A064.
    SMRiB9A064. Positions 40-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini115 – 20995Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni98 – 10912J region (By similarity to lambda light-chain)Add
    BLAST
    Regioni110 – 214105C region (By similarity to lambda light-chain)Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG76644.
    HOVERGENiHBG108319.
    OrthoDBiEOG7HTHJS.
    PhylomeDBiB9A064.
    TreeFamiTF335549.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B9A064-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRPKTGQVGC ETPEELGPGP RQRWPLLLLG LAMVAHGLLR PMVAPQSGDP    50
    DPGASVGSSR SSLRSLWGRL LLQPSPQRAD PRCWPRGFWS EPQSLCYVFG 100
    TGTKVTVLGQ PKANPTVTLF PPSSEELQAN KATLVCLISD FYPGAVTVAW 150
    KADGSPVKAG VETTKPSKQS NNKYAASSYL SLTPEQWKSH RSYSCQVTHE 200
    GSTVEKTVAP TECS 214

    Note: No experimental confirmation available.

    Length:214
    Mass (Da):23,063
    Last modified:March 8, 2011 - v2
    Checksum:iA29B29F09C063EBC
    GO
    Isoform 2 (identifier: B9A064-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-84: LLLQPSPQRADPRCW → SAQGQPHCHSVPALL
         85-214: Missing.

    Show »
    Length:84
    Mass (Da):8,843
    Checksum:i668BAC17435C50E8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei70 – 8415LLLQP…DPRCW → SAQGQPHCHSVPALL in isoform 2. 1 PublicationVSP_040709Add
    BLAST
    Alternative sequencei85 – 214130Missing in isoform 2. 1 PublicationVSP_040710Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87023 Genomic DNA. No translation available.
    CCDSiCCDS54506.1. [B9A064-1]
    RefSeqiNP_001171597.1. NM_001178126.1. [B9A064-1]
    UniGeneiHs.449585.
    Hs.625768.

    Genome annotation databases

    EnsembliENST00000526893; ENSP00000431254; ENSG00000254709. [B9A064-1]
    ENST00000531372; ENSP00000434368; ENSG00000254709. [B9A064-2]
    GeneIDi100423062.
    KEGGihsa:100423062.
    UCSCiuc011aiw.2. human. [B9A064-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87023 Genomic DNA. No translation available.
    CCDSi CCDS54506.1. [B9A064-1 ]
    RefSeqi NP_001171597.1. NM_001178126.1. [B9A064-1 ]
    UniGenei Hs.449585.
    Hs.625768.

    3D structure databases

    ProteinModelPortali B9A064.
    SMRi B9A064. Positions 40-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1148096. 5 interactions.

    PTM databases

    PhosphoSitei B9A064.

    Proteomic databases

    PaxDbi B9A064.
    PRIDEi B9A064.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000526893 ; ENSP00000431254 ; ENSG00000254709 . [B9A064-1 ]
    ENST00000531372 ; ENSP00000434368 ; ENSG00000254709 . [B9A064-2 ]
    GeneIDi 100423062.
    KEGGi hsa:100423062.
    UCSCi uc011aiw.2. human. [B9A064-1 ]

    Organism-specific databases

    CTDi 100423062.
    GeneCardsi GC22P023299.
    HGNCi HGNC:38476. IGLL5.
    HPAi HPA046779.
    neXtProti NX_B9A064.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76644.
    HOVERGENi HBG108319.
    OrthoDBi EOG7HTHJS.
    PhylomeDBi B9A064.
    TreeFami TF335549.

    Miscellaneous databases

    NextBioi 34053517.
    PROi B9A064.

    Gene expression databases

    Bgeei B9A064.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains."
      Guglielmi P., Davi F.
      Eur. J. Immunol. 21:501-508(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution."
      Evans R.J., Hollis G.F.
      J. Exp. Med. 173:305-311(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiIGLL5_HUMAN
    AccessioniPrimary (citable) accession number: B9A064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 43 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3