Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B9A064

- IGLL5_HUMAN

UniProt

B9A064 - IGLL5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Immunoglobulin lambda-like polypeptide 5

Gene

IGLL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda-like polypeptide 5
Alternative name(s):
G lambda-1
Germline immunoglobulin lambda 1
Gene namesi
Name:IGLL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:38476. IGLL5.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 214179Immunoglobulin lambda-like polypeptide 5PRO_0000405596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi136 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiB9A064.
PaxDbiB9A064.
PRIDEiB9A064.

PTM databases

PhosphoSiteiB9A064.

Expressioni

Tissue specificityi

Contrary to IGLL1, not expressed in pre-B-cells.2 Publications

Gene expression databases

BgeeiB9A064.
ExpressionAtlasiB9A064. baseline.

Organism-specific databases

HPAiHPA046779.

Interactioni

Protein-protein interaction databases

BioGridi1148096. 11 interactions.

Structurei

3D structure databases

ProteinModelPortaliB9A064.
SMRiB9A064. Positions 40-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 20995Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 10912J region (By similarity to lambda light-chain)Add
BLAST
Regioni110 – 214105C region (By similarity to lambda light-chain)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG76644.
GeneTreeiENSGT00730000110696.
HOVERGENiHBG108319.
InParanoidiB9A064.
OrthoDBiEOG7HTHJS.
PhylomeDBiB9A064.
TreeFamiTF335549.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B9A064-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPKTGQVGC ETPEELGPGP RQRWPLLLLG LAMVAHGLLR PMVAPQSGDP
60 70 80 90 100
DPGASVGSSR SSLRSLWGRL LLQPSPQRAD PRCWPRGFWS EPQSLCYVFG
110 120 130 140 150
TGTKVTVLGQ PKANPTVTLF PPSSEELQAN KATLVCLISD FYPGAVTVAW
160 170 180 190 200
KADGSPVKAG VETTKPSKQS NNKYAASSYL SLTPEQWKSH RSYSCQVTHE
210
GSTVEKTVAP TECS

Note: No experimental confirmation available.

Length:214
Mass (Da):23,063
Last modified:March 8, 2011 - v2
Checksum:iA29B29F09C063EBC
GO
Isoform 2 (identifier: B9A064-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-84: LLLQPSPQRADPRCW → SAQGQPHCHSVPALL
     85-214: Missing.

Show »
Length:84
Mass (Da):8,843
Checksum:i668BAC17435C50E8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 8415LLLQP…DPRCW → SAQGQPHCHSVPALL in isoform 2. 1 PublicationVSP_040709Add
BLAST
Alternative sequencei85 – 214130Missing in isoform 2. 1 PublicationVSP_040710Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87023 Genomic DNA. No translation available.
CCDSiCCDS54506.1. [B9A064-1]
RefSeqiNP_001171597.1. NM_001178126.1. [B9A064-1]
UniGeneiHs.449585.
Hs.625768.

Genome annotation databases

EnsembliENST00000526893; ENSP00000431254; ENSG00000254709. [B9A064-1]
ENST00000531372; ENSP00000434368; ENSG00000254709. [B9A064-2]
GeneIDi100423062.
KEGGihsa:100423062.
UCSCiuc011aiw.2. human. [B9A064-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87023 Genomic DNA. No translation available.
CCDSi CCDS54506.1. [B9A064-1 ]
RefSeqi NP_001171597.1. NM_001178126.1. [B9A064-1 ]
UniGenei Hs.449585.
Hs.625768.

3D structure databases

ProteinModelPortali B9A064.
SMRi B9A064. Positions 40-214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1148096. 11 interactions.

PTM databases

PhosphoSitei B9A064.

Proteomic databases

MaxQBi B9A064.
PaxDbi B9A064.
PRIDEi B9A064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000526893 ; ENSP00000431254 ; ENSG00000254709 . [B9A064-1 ]
ENST00000531372 ; ENSP00000434368 ; ENSG00000254709 . [B9A064-2 ]
GeneIDi 100423062.
KEGGi hsa:100423062.
UCSCi uc011aiw.2. human. [B9A064-1 ]

Organism-specific databases

CTDi 100423062.
GeneCardsi GC22P023317.
HGNCi HGNC:38476. IGLL5.
HPAi HPA046779.
neXtProti NX_B9A064.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG76644.
GeneTreei ENSGT00730000110696.
HOVERGENi HBG108319.
InParanoidi B9A064.
OrthoDBi EOG7HTHJS.
PhylomeDBi B9A064.
TreeFami TF335549.

Miscellaneous databases

GenomeRNAii 100423062.
NextBioi 34053517.
PROi B9A064.

Gene expression databases

Bgeei B9A064.
ExpressionAtlasi B9A064. baseline.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains."
    Guglielmi P., Davi F.
    Eur. J. Immunol. 21:501-508(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution."
    Evans R.J., Hollis G.F.
    J. Exp. Med. 173:305-311(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIGLL5_HUMAN
AccessioniPrimary (citable) accession number: B9A064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 29, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3