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Protein

Immunoglobulin lambda-like polypeptide 5

Gene

IGLL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda-like polypeptide 5
Alternative name(s):
G lambda-1
Germline immunoglobulin lambda 1
Gene namesi
Name:IGLL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:38476. IGLL5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000254709.

Polymorphism and mutation databases

BioMutaiIGLL5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000040559636 – 214Immunoglobulin lambda-like polypeptide 5Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi136 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiB9A064.
PaxDbiB9A064.
PRIDEiB9A064.

PTM databases

iPTMnetiB9A064.
PhosphoSitePlusiB9A064.

Expressioni

Tissue specificityi

Contrary to IGLL1, not expressed in pre-B-cells.2 Publications

Gene expression databases

BgeeiENSG00000254709.
ExpressionAtlasiB9A064. baseline and differential.
GenevisibleiB9A064. HS.

Organism-specific databases

HPAiHPA046779.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1148096. 21 interactors.
IntActiB9A064. 1 interactor.
STRINGi9606.ENSP00000431254.

Structurei

3D structure databases

ProteinModelPortaliB9A064.
SMRiB9A064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 209Ig-like C1-typeAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 109J region (By similarity to lambda light-chain)Add BLAST12
Regioni110 – 214C region (By similarity to lambda light-chain)Add BLAST105

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J0XA. Eukaryota.
ENOG410YZ00. LUCA.
GeneTreeiENSGT00730000110696.
HOVERGENiHBG108319.
InParanoidiB9A064.
PhylomeDBiB9A064.
TreeFamiTF335549.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B9A064-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPKTGQVGC ETPEELGPGP RQRWPLLLLG LAMVAHGLLR PMVAPQSGDP
60 70 80 90 100
DPGASVGSSR SSLRSLWGRL LLQPSPQRAD PRCWPRGFWS EPQSLCYVFG
110 120 130 140 150
TGTKVTVLGQ PKANPTVTLF PPSSEELQAN KATLVCLISD FYPGAVTVAW
160 170 180 190 200
KADGSPVKAG VETTKPSKQS NNKYAASSYL SLTPEQWKSH RSYSCQVTHE
210
GSTVEKTVAP TECS
Note: No experimental confirmation available.
Length:214
Mass (Da):23,063
Last modified:March 8, 2011 - v2
Checksum:iA29B29F09C063EBC
GO
Isoform 2 (identifier: B9A064-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-84: LLLQPSPQRADPRCW → SAQGQPHCHSVPALL
     85-214: Missing.

Show »
Length:84
Mass (Da):8,843
Checksum:i668BAC17435C50E8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04070970 – 84LLLQP…DPRCW → SAQGQPHCHSVPALL in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_04071085 – 214Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87023 Genomic DNA. No translation available.
CCDSiCCDS54506.1. [B9A064-1]
RefSeqiNP_001171597.1. NM_001178126.1. [B9A064-1]
UniGeneiHs.449585.
Hs.474325.
Hs.535668.
Hs.625768.
Hs.640434.
Hs.659929.
Hs.713252.
Hs.728722.
Hs.728758.
Hs.731137.

Genome annotation databases

EnsembliENST00000526893; ENSP00000431254; ENSG00000254709. [B9A064-1]
ENST00000531372; ENSP00000434368; ENSG00000254709. [B9A064-2]
GeneIDi100423062.
KEGGihsa:100423062.
UCSCiuc011aiw.3. human. [B9A064-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87023 Genomic DNA. No translation available.
CCDSiCCDS54506.1. [B9A064-1]
RefSeqiNP_001171597.1. NM_001178126.1. [B9A064-1]
UniGeneiHs.449585.
Hs.474325.
Hs.535668.
Hs.625768.
Hs.640434.
Hs.659929.
Hs.713252.
Hs.728722.
Hs.728758.
Hs.731137.

3D structure databases

ProteinModelPortaliB9A064.
SMRiB9A064.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1148096. 21 interactors.
IntActiB9A064. 1 interactor.
STRINGi9606.ENSP00000431254.

PTM databases

iPTMnetiB9A064.
PhosphoSitePlusiB9A064.

Polymorphism and mutation databases

BioMutaiIGLL5.

Proteomic databases

MaxQBiB9A064.
PaxDbiB9A064.
PRIDEiB9A064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000526893; ENSP00000431254; ENSG00000254709. [B9A064-1]
ENST00000531372; ENSP00000434368; ENSG00000254709. [B9A064-2]
GeneIDi100423062.
KEGGihsa:100423062.
UCSCiuc011aiw.3. human. [B9A064-1]

Organism-specific databases

CTDi100423062.
GeneCardsiIGLL5.
HGNCiHGNC:38476. IGLL5.
HPAiHPA046779.
neXtProtiNX_B9A064.
OpenTargetsiENSG00000254709.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XA. Eukaryota.
ENOG410YZ00. LUCA.
GeneTreeiENSGT00730000110696.
HOVERGENiHBG108319.
InParanoidiB9A064.
PhylomeDBiB9A064.
TreeFamiTF335549.

Miscellaneous databases

GenomeRNAii100423062.
PROiB9A064.

Gene expression databases

BgeeiENSG00000254709.
ExpressionAtlasiB9A064. baseline and differential.
GenevisibleiB9A064. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGLL5_HUMAN
AccessioniPrimary (citable) accession number: B9A064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 2, 2016
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.