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Protein
Submitted name:

Tumor necrosis factor receptor superfamily member 14

Gene

TNFRSF14

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily member 14Imported
Gene namesi
Name:TNFRSF14Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11912. TNFRSF14.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157873.
ENSG00000273936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_500764561239 – 193Sequence analysisAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 67PROSITE-ProRule annotation
Disulfide bondi57 ↔ 75PROSITE-ProRule annotation
Disulfide bondi78 ↔ 93PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PeptideAtlasiB9A034.

Expressioni

Gene expression databases

BgeeiENSG00000157873.
ExpressionAtlasiB9A034. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347948.

Structurei

3D structure databases

ProteinModelPortaliB9A034.
SMRiB9A034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 75TNFR-CysInterPro annotationAdd BLAST35
Repeati41 – 75TNFR-CysPROSITE-ProRule annotationAdd BLAST35
Domaini77 – 119TNFR-CysInterPro annotationAdd BLAST43
Repeati77 – 119TNFR-CysPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IX15. Eukaryota.
ENOG410ZEC2. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000065766.
HOVERGENiHBG072084.

Family and domain databases

CDDicd10582. TNFRSF14. 1 hit.
InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022332. TNFR_14.
IPR034031. TNFRSF14/UL144_N.
PfamiView protein in Pfam
PF00020. TNFR_c6. 1 hit.
PRINTSiPR01965. TNFACTORR14.
SMARTiView protein in SMART
SM00208. TNFR. 3 hits.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.

Sequencei

Sequence statusi: Complete.

B9A034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG
60 70 80 90 100
SECCPKCSPG YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD
110 120 130 140 150
PAMGLRASRN CSRTENAVCG CSPGHFCIVQ DGDHCAACRA YATSSPGQRV
160 170 180 190
QKGGTESQDT LCQNCPPGTF SPNGTLEECQ HQTNRAWKSQ TDL
Length:193
Mass (Da):20,753
Last modified:March 3, 2009 - v1
Checksum:iA9AB162A56C20B1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139246 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000409119; ENSP00000386859; ENSG00000157873.
ENST00000625695; ENSP00000485884; ENSG00000273936.
UCSCiuc057bnm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139246 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB9A034.
SMRiB9A034.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347948.

Proteomic databases

PeptideAtlasiB9A034.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409119; ENSP00000386859; ENSG00000157873.
ENST00000625695; ENSP00000485884; ENSG00000273936.
UCSCiuc057bnm.1. human.

Organism-specific databases

HGNCiHGNC:11912. TNFRSF14.
OpenTargetsiENSG00000157873.
ENSG00000273936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX15. Eukaryota.
ENOG410ZEC2. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000065766.
HOVERGENiHBG072084.

Miscellaneous databases

ChiTaRSiTNFRSF14. human.
GenomeRNAii8764.

Gene expression databases

BgeeiENSG00000157873.
ExpressionAtlasiB9A034. baseline and differential.

Family and domain databases

CDDicd10582. TNFRSF14. 1 hit.
InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022332. TNFR_14.
IPR034031. TNFRSF14/UL144_N.
PfamiView protein in Pfam
PF00020. TNFR_c6. 1 hit.
PRINTSiPR01965. TNFACTORR14.
SMARTiView protein in SMART
SM00208. TNFR. 3 hits.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiB9A034_HUMAN
AccessioniPrimary (citable) accession number: B9A034
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 15, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.