ID   B8ZZJ4_HUMAN            Unreviewed;        37 AA.
AC   B8ZZJ4;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=Calcitonin gene-related peptide type 1 receptor {ECO:0000256|RuleBase:RU368099};
DE            Short=CGRP type 1 receptor {ECO:0000256|RuleBase:RU368099};
DE   AltName: Full=Calcitonin receptor-like receptor {ECO:0000256|RuleBase:RU368099};
DE   Flags: Fragment;
GN   Name=CALCRL {ECO:0000313|Ensembl:ENSP00000386599.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386599.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386599.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386599.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) together
CC       with RAMP1 and receptor for adrenomedullin together with RAMP2 or
CC       RAMP3. The activity of this receptor is mediated by G proteins which
CC       activate adenylyl cyclase. {ECO:0000256|RuleBase:RU368099}.
CC   -!- SUBUNIT: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
CC       {ECO:0000256|RuleBase:RU368099}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU368099};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU368099}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|RuleBase:RU368099}.
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DR   EMBL; AC007319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC074020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; B8ZZJ4; -.
DR   MassIVE; B8ZZJ4; -.
DR   Antibodypedia; 1959; 309 antibodies from 32 providers.
DR   Ensembl; ENST00000410102.5; ENSP00000386599.1; ENSG00000064989.13.
DR   UCSC; uc061qmn.1; human.
DR   HGNC; HGNC:16709; CALCRL.
DR   VEuPathDB; HostDB:ENSG00000064989; -.
DR   GeneTree; ENSGT00940000159898; -.
DR   HOGENOM; CLU_3353404_0_0_1; -.
DR   OMA; AIVICIY; -.
DR   ChiTaRS; CALCRL; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000064989; Expressed in right lung and 150 other cell types or tissues.
DR   ExpressionAtlas; B8ZZJ4; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004948; F:calcitonin receptor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003289; GPCR_2_CGRP1_rcpt.
DR   PRINTS; PR01351; CGRPRECEPTOR.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|RuleBase:RU368099};
KW   Disulfide bond {ECO:0000256|RuleBase:RU368099};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU368099};
KW   Glycoprotein {ECO:0000256|RuleBase:RU368099};
KW   Membrane {ECO:0000256|RuleBase:RU368099};
KW   Receptor {ECO:0000256|RuleBase:RU368099};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU368099, ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|RuleBase:RU368099}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..37
FT                   /note="Calcitonin gene-related peptide type 1 receptor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002880913"
FT   NON_TER         37
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000386599.1"
SQ   SEQUENCE   37 AA;  4249 MW;  0050CFE7870DAB1B CRC64;
     MEKKCTLYFL VLLPFFMILV TAELEESPED SIQLGVT
//