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Protein

Alkylglycerone-phosphate synthase

Gene

AGPS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.UniRule annotation

Catalytic activityi

1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: ether lipid biosynthesis

This protein is involved in the pathway ether lipid biosynthesis, which is part of Glycerolipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ether lipid biosynthesis and in Glycerolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processLipid biosynthesisUniRule annotation, Lipid metabolism
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00781.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkylglycerone-phosphate synthaseUniRule annotation (EC:2.5.1.26UniRule annotation)
Short name:
Alkyl-DHAP synthaseUniRule annotation
Gene namesi
Name:AGPSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000018510.12.
HGNCiHGNC:327. AGPS.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

PeroxisomeUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000018510.

PTM / Processingi

Proteomic databases

MaxQBiB8ZZ81.
PaxDbiB8ZZ81.
PeptideAtlasiB8ZZ81.
PRIDEiB8ZZ81.

Expressioni

Gene expression databases

BgeeiENSG00000018510.
ExpressionAtlasiB8ZZ81. baseline and differential.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8ZZ81.
SMRiB8ZZ81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 186FAD-oxidase_CInterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the FAD-binding oxidoreductase/transferase type 4 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1233. Eukaryota.
COG0277. LUCA.
GeneTreeiENSGT00530000063515.

Family and domain databases

Gene3Di1.10.45.10. 1 hit.
InterProiView protein in InterPro
IPR025650. Alkyl-DHAP_Synthase.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
PANTHERiPTHR11748:SF3. PTHR11748:SF3. 2 hits.
PfamiView protein in Pfam
PF02913. FAD-oxidase_C. 1 hit.
SUPFAMiSSF55103. SSF55103. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZZ81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAAAAAGG TGLGAGASYG SAADRDRDPD PDRAGRRLRV LSGHLLGRPR
60 70 80 90 100
EALSTNECKA RRAASAATAA PTATPAAQES GTIPKKRQEV MKWNGWGYND
110 120 130 140 150
SKFIFNKKGQ IELTGKRGIS DPLTVFEQTE AAAREEILAN GGSLSHHHGV
160 170 180
GKLRKQWLKE SISDVGFGML KSVKEYVDPN NIFGNRNLL
Length:189
Mass (Da):20,215
Last modified:March 3, 2009 - v1
Checksum:i561EA59F4217A09B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016762 Genomic DNA. No translation available.
AC019080 Genomic DNA. No translation available.
AC073834 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000409888; ENSP00000386688; ENSG00000018510.
UCSCiuc061qas.1. human.

Similar proteinsi

Entry informationi

Entry nameiB8ZZ81_HUMAN
AccessioniPrimary (citable) accession number: B8ZZ81
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 25, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported