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Protein
Submitted name:

Malate dehydrogenase, cytoplasmic

Gene

MDH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Malate dehydrogenase, cytoplasmicImported
Gene namesi
Name:MDH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6970. MDH1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000014641.

PTM / Processingi

Proteomic databases

MaxQBiB8ZZ51.
PaxDbiB8ZZ51.
PeptideAtlasiB8ZZ51.
PRIDEiB8ZZ51.

Expressioni

Gene expression databases

BgeeiENSG00000014641.
ExpressionAtlasiB8ZZ51. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000438144.

Structurei

3D structure databases

ProteinModelPortaliB8ZZ51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 165Ldh_1_CInterPro annotationAdd BLAST165

Phylogenomic databases

eggNOGiKOG1496. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00530000063410.
HOGENOMiHOG000220953.
HOVERGENiHBG006340.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
InterProiIPR022383. Lactate/malate_DH_C.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZZ51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIALKLGVTA NDVKNVIIWG NHSSTQYPDV NHAKVKLQGK EVGVYEALKD
60 70 80 90 100
DSWLKGEFVT TVQQRGAAVI KARKLSSAMS AAKAICDHVR DIWFGTPEGE
110 120 130 140 150
FVSMGVISDG NSYGVPDDLL YSFPVVIKNK TWKFVEGLPI NDFSREKMDL
160
TAKELTEEKE SAFEFLSSA
Length:169
Mass (Da):18,689
Last modified:March 3, 2009 - v1
Checksum:iD448726EF36770D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016734 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000409908; ENSP00000386743; ENSG00000014641.
UCSCiuc061jrg.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016734 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB8ZZ51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000438144.

Proteomic databases

MaxQBiB8ZZ51.
PaxDbiB8ZZ51.
PeptideAtlasiB8ZZ51.
PRIDEiB8ZZ51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409908; ENSP00000386743; ENSG00000014641.
UCSCiuc061jrg.1. human.

Organism-specific databases

HGNCiHGNC:6970. MDH1.
OpenTargetsiENSG00000014641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1496. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00530000063410.
HOGENOMiHOG000220953.
HOVERGENiHBG006340.

Miscellaneous databases

ChiTaRSiMDH1. human.

Gene expression databases

BgeeiENSG00000014641.
ExpressionAtlasiB8ZZ51. baseline and differential.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
InterProiIPR022383. Lactate/malate_DH_C.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB8ZZ51_HUMAN
AccessioniPrimary (citable) accession number: B8ZZ51
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.