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Protein
Submitted name:

Large T antigen

Gene

LT-Ag

Organism
Merkel cell polyomavirus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi316 – 430T-ag OBDPROSITE-ProRule annotationAdd BLAST115

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation, HydrolaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Large T antigenImported
Gene namesi
Name:LT-AgImported
OrganismiMerkel cell polyomavirusImported
Taxonomic identifieri493803 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolyomaviridaeunclassified Polyomaviridae

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 430T-ag OBD DNA-bindingInterPro annotationAdd BLAST115
Domaini437 – 528T-ag D1-typeInterPro annotationAdd BLAST92
Domaini567 – 727SF3 helicaseInterPro annotationAdd BLAST161

Family and domain databases

Gene3Di1.10.10.510. 1 hit.
1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR014015. Helicase_SF3_DNA-vir.
IPR010932. Lg_T_Ag_Polyomavir_C.
IPR027417. P-loop_NTPase.
IPR003133. T_Ag_DNA-bd.
IPR017910. Znf_lg_T-Ag_D1-typ.
PfamiView protein in Pfam
PF06431. Polyoma_lg_T_C. 1 hit.
PF02217. T_Ag_DNA_bind. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51206. SF3_HELICASE_1. 1 hit.
PS51287. T_AG_OBD. 1 hit.
PS51341. ZF_LTAG_D1. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZX42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVLNRKER EALCKLLEIA PNCYGNIPLM KAAFKRSCLK HHPDKGGNPV
60 70 80 90 100
IMMELNTLWS KFQQNIHKLR SDFSMFDEVD EAPIYGTTKF KEWWRSGGFS
110 120 130 140 150
FGKAYEYGPN PHGTNSRSRK PSSNASRGAP SGSSPPHSQS SSSGYGSFSA
160 170 180 190 200
SQASDSQSRG PDIPPEHHEE PTSSSGSSSR EETTNSGRES STPNGTSVPR
210 220 230 240 250
NSSRTDGTWE DLFCDESLSS PEPPSSSEEP EEPPSSRSSP RQPPSSSAEE
260 270 280 290 300
ASSSQFTDEE YRSSSFTTPK TPPPFSRKRK FGGSRSSASS ASSASFTSTP
310 320 330 340 350
PKPKKNRETP VPTDFPIDLS DYLSHAVYSN KTVSCFAIYT TSDKAIELYD
360 370 380 390 400
KIEKFKVDFK SRHACELGCI LLFITLSKHR VSAIKNFCST FCTISFLICK
410 420 430 440 450
GVNKMPEMYN NLCKPPYKLL QEDKPLLNYE FQEKEKEASC NWNLVAEFAC
460 470 480 490 500
EYELDDHFII LAHYLDFAKP FPCQKCENRS RLKPHKAHEA HHSNAKLFYE
510 520 530 540 550
SKSQKTICQQ AADTVLAKRR LEMLEMTRTE TLCKKFKKHL ERLRDLDTID
560 570 580 590 600
LLYYMGGVAW YCCLFEEFEK KLQKIIQLLT ENIPKYRNIW FKGPINSGKT
610 620 630 640 650
SFAAALIDLL EGKALNINCP SDKLPFELGC ALDKFMVVFE DVKGQNSLNK
660 670 680 690 700
DLQPGQGINN LDNLRDHLDG AVAVSLEKKH ANKKHQIFPP CIVTANDYFI
710 720 730 740 750
PKTLIARFSY TLHFSPKANL RDSLDQNMEI RKRRILQSGT TLLLCLIWCL
760 770 780 790 800
PDTTFKPCLQ EEIKNWKQIL QSEISYGKFC QMIENVEAGQ DPLLNILIEE
810
EGPEETEETQ DSGTFSQ
Length:817
Mass (Da):92,281
Last modified:March 3, 2009 - v1
Checksum:i0CBF20070C0C2EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM955586 Genomic DNA. Translation: CAW30976.1.
FM955592 Genomic DNA. Translation: CAW30988.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM955586 Genomic DNA. Translation: CAW30976.1.
FM955592 Genomic DNA. Translation: CAW30988.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.10.510. 1 hit.
1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR014015. Helicase_SF3_DNA-vir.
IPR010932. Lg_T_Ag_Polyomavir_C.
IPR027417. P-loop_NTPase.
IPR003133. T_Ag_DNA-bd.
IPR017910. Znf_lg_T-Ag_D1-typ.
PfamiView protein in Pfam
PF06431. Polyoma_lg_T_C. 1 hit.
PF02217. T_Ag_DNA_bind. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51206. SF3_HELICASE_1. 1 hit.
PS51287. T_AG_OBD. 1 hit.
PS51341. ZF_LTAG_D1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB8ZX42_9POLY
AccessioniPrimary (citable) accession number: B8ZX42
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 12, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.