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B8ZUY5 (B8ZUY5_MYCLB) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N5-carboxyaminoimidazole ribonucleotide mutase PIRNR PIRNR001338
Short name=N5-CAIR mutase PIRNR PIRNR001338
EC=5.4.99.18 PIRNR PIRNR001338
Gene names
Name:purE EMBL CAR70830.1
Ordered Locus Names:MLBr00736
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity. PIRNR PIRNR001338

Catalytic activity

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. PIRNR PIRNR001338

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. PIRNR PIRNR001338

Sequence similarities

Belongs to the AIR carboxylase family. PIRNR PIRNR001338

Sequences

Sequence LengthMass (Da)Tools
B8ZUY5 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: DBB69909059894E3

FASTA17117,912
        10         20         30         40         50         60 
MTRQPRVGVI MGSDSDWSVM QDAAHALAEF DIPIEVRVVS AHRTPAEMFD YARNAVDRSI 

        70         80         90        100        110        120 
AVIIAGAGGA AHLPGMVASA TPLPVIGVPV PLARLDGLDS LLSIVQMPAG VPVATVSIGG 

       130        140        150        160        170 
ARNAGLLAVR ILGSSDLQLR AQLVAFQDRL ADTVRAKDAD LQRFRGKLIG D

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR70830.1.
RefSeqYP_002503207.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZUY5.
SMRB8ZUY5. Positions 7-134.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZUY5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000085367; EBMYCP00000082991; EBMYCG00000085615.
GeneID7325039.
GenomeReviewsGene locus MLBr00736 in contig FM211192_GR.
PATRIC18042210. VBIMycLep121698_1336.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016911.
HOGENOMHBG301965.
OMALIMGSDS.
ProtClustDBCLSK792398.

Family and domain databases

InterProIPR024694. N5-CAIR_mutase_PurE.
IPR000031. N5-CAIR_Mutase_PurE_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
PfamPF00731. AIRC. 1 hit.
[Graphical view]
PIRSFPIRSF001338. AIR_carboxylase. 1 hit.
SMARTSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMSSF52255. AIR_carboxyl. 1 hit.
TIGRFAMsTIGR01162. PurE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8ZUY5_MYCLB
AccessionPrimary (citable) accession number: B8ZUY5
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info