B8ZUV3 (SSRP_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SsrA-binding protein

Gene names

Name:	smpB
Ordered Locus Names:	MLBr00671

Organism

Mycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]

Taxonomic identifier

561304 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes By similarity. HAMAP MF_00023
Subcellular location	Cytoplasm Potential HAMAP MF_00023.
Sequence similarities	Belongs to the SmpB family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	SsrA-binding protein HAMAP MF_00023		PRO_1000197617

Sequences

	Sequence		Length	Mass (Da)
	B8ZUV3 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 99914B92F4F7CFC2	FASTA	160	18,205
	10 20 30 40 50 60 MARNPRGGKQ IVATNRKARH DYAIIELFEA GVALLGTEVK SLREGHASLA DAFATVDSGE 70 80 90 100 110 120 VWLRNMHIPE YQHGSWTNHD PRRNRKLLLH RRQIDTLVGK IRDGNLALVP LSLYFAEGKV 130 140 150 160 KVELALARGK KLHDKRQDMA RRDAQREVIR ELGRRAKGML

References

[1]

"Comparative genomic and phylogeographic analysis of Mycobacterium leprae." Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L. , Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T. Nat. Genet. 41:1282-1289(2009) [PubMed: 19881526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Br4923.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211192 Genomic DNA. Translation: CAR70765.1.
RefSeq	YP_002503175.1. NC_011896.1.
3D structure databases
ProteinModelPortal	B8ZUV3.
SMR	B8ZUV3. Positions 11-130.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZUV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000086092; EBMYCP00000081608; EBMYCG00000085682.
GeneID	7325316.
GenomeReviews	Gene locus MLBr00671 in contig FM211192_GR.
PATRIC	18041934. VBIMycLep121698_1197.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017126.
HOGENOM	HBG293422.
OMA	EKYEAGI.
ProtClustDB	PRK05422.
Family and domain databases
HAMAP	MF_00023. SmpB. [Tree]
InterPro	IPR023620. SmpB. IPR000037. SsrA-bd_prot. IPR020081. SsrA-bd_prot_CS. [Graphical view]
Gene3D	G3DSA:2.40.280.10. SmpB. 1 hit.
Pfam	PF01668. SmpB. 1 hit. [Graphical view]
ProDom	PD004488. SmpB. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF74982. SmpB. 1 hit.
TIGRFAMs	TIGR00086. SmpB. 1 hit.
PROSITE	PS01317. SSRP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSRP_MYCLB

Accession

Primary (citable) accession number: B8ZUV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program