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B8ZUQ2 (TAL_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Transaldolase
EC=2.2.1.2
Gene names
Name:tal
Ordered Locus Names:MLBr00582
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway By similarity. HAMAP MF_00493

Catalytic activity

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. HAMAP MF_00493

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. HAMAP MF_00493

Subcellular location

Cytoplasm By similarity HAMAP MF_00493.

Sequence similarities

Belongs to the transaldolase family. Type 2 subfamily.

Ontologies

Keywords
   Biological processPentose shunt
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Transaldolase HAMAP MF_00493
PRO_1000198459

Sites

Active site1451 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8ZUQ2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 10FCFB4765D665AB

FASTA37540,588
        10         20         30         40         50         60 
MTSKIQNPNL AALSAAGVSV WLDDLSRDRL QSGNLQKLID TKSVVGVTTN PSIFQKAFAN 

        70         80         90        100        110        120 
GHAYDAQIAE LAKRGANVDV TVRTVTTDDV RHACDVLACE WEASHGKDGR VSIEVDPRLA 

       130        140        150        160        170        180 
HDTDKTIAQA VELWRIVDHP NLFIKIPATK AGLPAITAVL AEGISVNVTL IFSVQRHREV 

       190        200        210        220        230        240 
IDAYLAGIEK AAEAGRDLSK IVSVASFFVS RVDTEIDKRL EKLGSEQALA LRGQAGVANA 

       250        260        270        280        290        300 
RLAYAAYQKA FEGGQRYQTL MARGAQVQRP LWASTGVKNP DYADTLYVTE LVAPNTVNTM 

       310        320        330        340        350        360 
PETTIDAVAD HGVIRGDTIS GTTLSSQKVF DSLVAVGVDL IDVFAVLEHE GVQKFVKSWN 

       370 
ELLKETQEQL DSVAK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR70675.1.
RefSeqYP_002503124.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZUQ2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZUQ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000086788; EBMYCP00000082423; EBMYCG00000087367.
GeneID7327329.
GenomeReviewsGene locus MLBr00582 in contig FM211192_GR.
PATRIC18041566. VBIMycLep121698_1014.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017406.
HOGENOMHBG321149.
OMAMPEKTLD.
ProtClustDBPRK03343.

Family and domain databases

HAMAPMF_00493. Transaldolase_2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR001585. Transaldolase.
IPR004732. Transaldolase_2.
IPR018225. Transaldolase_AS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR10683. Transaldolase. 1 hit.
PfamPF00923. Transaldolase. 1 hit.
[Graphical view]
PIRSFPIRSF036915. Trnald_Bac_Plnt. 1 hit.
TIGRFAMsTIGR00876. Tal_mycobact. 1 hit.
PROSITEPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTAL_MYCLB
AccessionPrimary (citable) accession number: B8ZUQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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