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B8ZUP9

- B8ZUP9_MYCLB

UniProt

B8ZUP9 - B8ZUP9_MYCLB

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium leprae (strain Br4923)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei161 – 1611UniRule annotation
    Active sitei593 – 5931UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, PyruvateImported

    Enzyme and pathway databases

    BioCyciMLEP561304:GJP6-590-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotationImported
    Ordered Locus Names:MLBr00578Imported
    OrganismiMycobacterium leprae (strain Br4923)Imported
    Taxonomic identifieri561304 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006900: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi561304.MLBr_00578.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZUP9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2352.
    KOiK01595.
    OMAiHERTIAM.
    OrthoDBiEOG6TJ7T8.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8ZUP9-1 [UniParc]FASTAAdd to Basket

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    MVEFSDAILE PIGAVQRTRV GREATEPMRA DIRLLGTILG DTLREQNGDE    50
    VFDLVERVRV ESFRVRRSEI DRADMARMFS GLDIHLAIPI IRAFSHFALL 100
    ANVAEDIHRE RRRHIHLDAG EPLRDSSLAA TYAKLDLAKL DSATVADALT 150
    GAVVSPVITA HPTETRRRTV FVTQRRITEL MRLHAEGHTE TADGRSIERE 200
    LRRQILTLWQ TALIRLARLQ ISDEIDVGLR YYSAALFHVI PQVNSEVRNA 250
    LRARWPDAEL LSGPILQPGS WIGGDRDGNP NVTADVVRRA TGSAAYTVVA 300
    HYLAELTHLE QELSMSARLI TVTPELATLA ASCQDAACAD EPYRRALRVI 350
    RGRLSSTAAH ILDQQPPNQL GLGLPPYSTP AELCADLDTI EASLCTHGAA 400
    LLADDRLALL REGVGVFGFH LCGLDMRQNS DVHEEVVAEL LAWAGMHQDY 450
    SSLPEDQRVK LLVAELGNRR PLVGDRAQLS DLARGELAVL AAAAHAVELY 500
    GSAAVPNYII SMCQSVSDVL EVAILLKETG LLDASGSQPY CPVGISPLFE 550
    TIDDLHNGAA ILHAMLELPL YRTLVAARGN WQEVMLGYSD SNKDGGYLAA 600
    NWAVYRAELA LVDVARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA 650
    VNGSLRLTEQ GEVIAAKYAE PQIARRNLES LVAATLESTL LDVEGLGDAA 700
    ESAYAILDEV AGLARRSYAE LVNTPGFVDY FQASTPVSEI GSLNIGNRPT 750
    SRKPTTSIAD LRAIPWVLAW SQSRVMLPGW YGTGSAFQQW VAAGPESESQ 800
    RVEMLHDLYQ RWPFFRSVLS NMAQVLAKSD LGLAARYAEL VVDEALRRRV 850
    FDKIADEHRR TIAIHKLITG HDDLLADNPA LARSVFNRFP YLEPLNHLQV 900
    ELLRRYRSGH DDEMVQRGIL LTMNGLASAL RNSG 934
    Length:934
    Mass (Da):102,516
    Last modified:March 3, 2009 - v1
    Checksum:i3EE8FD762EC45180
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70671.1.
    RefSeqiYP_002503121.1. NC_011896.1.

    Genome annotation databases

    EnsemblBacteriaiCAR70671; CAR70671; MLBr00578.
    GeneIDi7326942.
    KEGGimlb:MLBr_00578.
    PATRICi18041548. VBIMycLep121698_1005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70671.1 .
    RefSeqi YP_002503121.1. NC_011896.1.

    3D structure databases

    ProteinModelPortali B8ZUP9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561304.MLBr_00578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR70671 ; CAR70671 ; MLBr00578 .
    GeneIDi 7326942.
    KEGGi mlb:MLBr_00578.
    PATRICi 18041548. VBIMycLep121698_1005.

    Phylogenomic databases

    eggNOGi COG2352.
    KOi K01595.
    OMAi HERTIAM.
    OrthoDBi EOG6TJ7T8.

    Enzyme and pathway databases

    BioCyci MLEP561304:GJP6-590-MONOMER.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Br4923Imported.

    Entry informationi

    Entry nameiB8ZUP9_MYCLB
    AccessioniPrimary (citable) accession number: B8ZUP9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3