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B8ZUP2

- PGK_MYCLB

UniProt

B8ZUP2 - PGK_MYCLB

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateUniRule annotation
    Binding sitei126 – 1261SubstrateUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Binding sitei216 – 2161ATPUniRule annotation
    Binding sitei304 – 3041ATP; via carbonyl oxygenUniRule annotation
    Binding sitei335 – 3351ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi364 – 3674ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLEP561304:GJP6-583-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:MLBr00571
    OrganismiMycobacterium leprae (strain Br4923)
    Taxonomic identifieri561304 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006900: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Phosphoglycerate kinasePRO_1000192839Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi561304.MLBr_00571.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZUP2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingUniRule annotation
    Regioni63 – 664Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.
    OMAiHASVYDI.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8ZUP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIPNLKDLL EEGVSGRCVL VRCDLNVPLG DDGAITDLGR VTASVPTLKA    50
    LLEAGAKIVV AAHLGRPKNG PDPKLSLEPV AAALGEQLGQ NVQLVCSTDR 100
    SPVGGDALAC VERLTDGDLL LLQNIRFDPR ETSKVDDERL ALAKQLVELV 150
    GSAGAFVSDG FGVVHRRQAS VYDVATLLPH YAGILVADEI RILEQLTSSA 200
    KRPYAVVLGG SKVSDKLGVI ESLATKADSI VLGGGMCFTF LAAQGFSVGK 250
    SLLETEMIET CRSLLDTYAD VLRLPMDIVV TEKFVADSPP QTVAADAIPD 300
    GLMGLDIGPE SVKRFATLLS NASTIFWNGP MGVFEFPAYA AGTRGVAEAI 350
    VAVTGKGAFS VVGGGDSAAA MRALSLPEGS VSHLSTGGGA SLEYLEGKTL 400
    PGIEVLGREQ PRGGDS 416
    Length:416
    Mass (Da):43,279
    Last modified:March 3, 2009 - v1
    Checksum:i559BAE226C9D2E53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70664.1.
    RefSeqiYP_002503114.1. NC_011896.1.

    Genome annotation databases

    EnsemblBacteriaiCAR70664; CAR70664; MLBr00571.
    GeneIDi7325330.
    KEGGimlb:MLBr_00571.
    PATRICi18041530. VBIMycLep121698_0996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70664.1 .
    RefSeqi YP_002503114.1. NC_011896.1.

    3D structure databases

    ProteinModelPortali B8ZUP2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561304.MLBr_00571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR70664 ; CAR70664 ; MLBr00571 .
    GeneIDi 7325330.
    KEGGi mlb:MLBr_00571.
    PATRICi 18041530. VBIMycLep121698_0996.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.
    OMAi HASVYDI.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci MLEP561304:GJP6-583-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Br4923.

    Entry informationi

    Entry nameiPGK_MYCLB
    AccessioniPrimary (citable) accession number: B8ZUP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3