B8ZUL9 (B8ZUL9_MYCLB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative guanylate kinase EMBL CAR70634.1
EC=2.7.4.8 EMBL CAR70634.1

Gene names

Name:	gmk EMBL CAR70634.1
Ordered Locus Names:	MLBr00541

Organism

Mycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]

Taxonomic identifier

561304 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. SAAS SAAS020590
Catalytic activity	ATP + GMP = ADP + GDP. SAAS SAAS020590
Subcellular location	Cytoplasm By similarity SAAS SAAS020590.
Sequence similarities	Contains 1 guanylate kinase-like domain. SAAS SAAS017665

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS020590
Ligand	ATP-binding SAAS SAAS020590 Nucleotide-binding
Molecular function	Kinase SAAS SAAS020590 EMBL CAR70634.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8ZUL9 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 51E1E72E5141E19B	FASTA	210	22,658
	10 20 30 40 50 60 MPVSARGAPD AEHWAWSEQT DKGRVVVLSG PSAVGKSTVV RCLRERVSNL HFSVSATTRE 70 80 90 100 110 120 PRPDEMDGVD YHFVSPARFQ QLIDQGALLE WAEIHGGMHR SGTLAEPVRV AAAAGFPVLI 130 140 150 160 170 180 EVDLAGARAV KKAMPEAIAV FLAPPSWEDL EARLVGRGTE TPEAIRRRLE TARIELAAQD 190 200 210 DFDEVVVNRR LESACAELVS LLVGAVSGSA

References

[1]

"Comparative genomic and phylogeographic analysis of Mycobacterium leprae." Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L. , Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T. Nat. Genet. 41:1282-1289(2009) [PubMed: 19881526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211192 Genomic DNA. Translation: CAR70634.1.
RefSeq	YP_002503091.1. NC_011896.1.
3D structure databases
ProteinModelPortal	B8ZUL9.
SMR	B8ZUL9. Positions 23-204.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZUL9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000086362; EBMYCP00000082549; EBMYCG00000086236.
GeneID	7324902.
GenomeReviews	Gene locus MLBr00541 in contig FM211192_GR.
PATRIC	18041412. VBIMycLep121698_0937.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017746.
HOGENOM	HBG671982.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. Guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8ZUL9_MYCLB

Accession

Primary (citable) accession number: B8ZUL9

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)