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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:MLBr00537
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006900 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002138931 – 282Orotidine 5'-phosphate decarboxylaseAdd BLAST282

Proteomic databases

PRIDEiB8ZUL5

Structurei

3D structure databases

ProteinModelPortaliB8ZUL5
SMRiB8ZUL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

KOiK01591
OMAiQSAFFER
OrthoDBiPOG091H09O1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR018089 OMPdecase_AS
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

B8ZUL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGFGARLVE ATSRRGQLCL GIDPHPELLR AWDLPTTADG LAAFCDICVE
60 70 80 90 100
AFSGFAIVKP QVAFFEAYGA AGFAVLEYTI AALRSVGVLV LADAKRGDIG
110 120 130 140 150
STMAAYAAAW AGNSPLAADA VTASPYLGFG SLRPLLEVAA AHDRGVFVLA
160 170 180 190 200
STSNLEGATV QRATFDGRIV AQLIVDQAAF VNREMNRSFH RSEPGCLGYV
210 220 230 240 250
GVVVGATVFG APDVSALGGP VLVPGVGAQG GHPEALGGLG GAAPGQLLPA
260 270 280
VSRAVLRAGP GVSELRAAGE QMRDAVAYLA AV
Length:282
Mass (Da):28,678
Last modified:March 3, 2009 - v1
Checksum:i89DE23C44B227BA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA Translation: CAR70630.1
RefSeqiWP_010907780.1, NC_011896.1

Genome annotation databases

EnsemblBacteriaiCAR70630; CAR70630; MLBr00537
KEGGimlb:MLBr00537

Similar proteinsi

Entry informationi

Entry nameiPYRF_MYCLB
AccessioniPrimary (citable) accession number: B8ZUL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health