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B8ZUL5

- PYRF_MYCLB

UniProt

B8ZUL5 - PYRF_MYCLB

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, MLBr00537
Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-549-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:MLBr00537
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000213893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561304.MLBr_00537.

Structurei

3D structure databases

ProteinModelPortaliB8ZUL5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiGSTMGAY.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZUL5-1 [UniParc]FASTAAdd to Basket

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MTGFGARLVE ATSRRGQLCL GIDPHPELLR AWDLPTTADG LAAFCDICVE    50
AFSGFAIVKP QVAFFEAYGA AGFAVLEYTI AALRSVGVLV LADAKRGDIG 100
STMAAYAAAW AGNSPLAADA VTASPYLGFG SLRPLLEVAA AHDRGVFVLA 150
STSNLEGATV QRATFDGRIV AQLIVDQAAF VNREMNRSFH RSEPGCLGYV 200
GVVVGATVFG APDVSALGGP VLVPGVGAQG GHPEALGGLG GAAPGQLLPA 250
VSRAVLRAGP GVSELRAAGE QMRDAVAYLA AV 282
Length:282
Mass (Da):28,678
Last modified:March 3, 2009 - v1
Checksum:i89DE23C44B227BA5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR70630.1.
RefSeqiWP_010907780.1. NC_011896.1.
YP_002503087.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR70630; CAR70630; MLBr00537.
GeneIDi7327267.
KEGGimlb:MLBr_00537.
PATRICi18041404. VBIMycLep121698_0933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR70630.1 .
RefSeqi WP_010907780.1. NC_011896.1.
YP_002503087.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZUL5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 561304.MLBr_00537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR70630 ; CAR70630 ; MLBr00537 .
GeneIDi 7327267.
KEGGi mlb:MLBr_00537.
PATRICi 18041404. VBIMycLep121698_0933.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi GSTMGAY.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci MLEP561304:GJP6-549-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiPYRF_MYCLB
AccessioniPrimary (citable) accession number: B8ZUL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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