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B8ZUL5 (PYRF_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:MLBr00537
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_1000213893

Sites

Active site951Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
B8ZUL5 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 89DE23C44B227BA5

FASTA28228,678
        10         20         30         40         50         60 
MTGFGARLVE ATSRRGQLCL GIDPHPELLR AWDLPTTADG LAAFCDICVE AFSGFAIVKP 

        70         80         90        100        110        120 
QVAFFEAYGA AGFAVLEYTI AALRSVGVLV LADAKRGDIG STMAAYAAAW AGNSPLAADA 

       130        140        150        160        170        180 
VTASPYLGFG SLRPLLEVAA AHDRGVFVLA STSNLEGATV QRATFDGRIV AQLIVDQAAF 

       190        200        210        220        230        240 
VNREMNRSFH RSEPGCLGYV GVVVGATVFG APDVSALGGP VLVPGVGAQG GHPEALGGLG 

       250        260        270        280 
GAAPGQLLPA VSRAVLRAGP GVSELRAAGE QMRDAVAYLA AV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM211192 Genomic DNA. Translation: CAR70630.1.
RefSeqYP_002503087.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZUL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING561304.MLBr_00537.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR70630; CAR70630; MLBr00537.
GeneID7327267.
KEGGmlb:MLBr_00537.
PATRIC18041404. VBIMycLep121698_0933.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
KOK01591.
OMAGSTMGAY.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycMLEP561304:GJP6-549-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_MYCLB
AccessionPrimary (citable) accession number: B8ZUL5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways