B8ZUD0 (B8ZUD0_MYCLB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp HAMAP MF_01445

Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein HAMAP MF_01445

Gene names

Name:	gcp HAMAP MF_01445 EMBL CAR70472.1
Ordered Locus Names:	MLBr00379

Organism

Mycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]

Taxonomic identifier

561304 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine By similarity. HAMAP MF_01445
Subcellular location	Cytoplasm By similarity HAMAP MF_01445 SAAS SAAS017860.
Sequence similarities	Belongs to the KAE1 / YgjD family. HAMAP MF_01445

Ontologies

Keywords
Biological process	tRNA processing HAMAP MF_01445 SAAS SAAS017860
Cellular component	Cytoplasm HAMAP MF_01445 SAAS SAAS017860
Molecular function	Hydrolase EMBL CAR70472.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro threonylcarbamoyladenosine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8ZUD0 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: F76A14B739A7BAE4	FASTA	351	35,406
	10 20 30 40 50 60 MTISAVPGTI ILAIETSCDE TGVGIACLDD YGTVTLLADE VASSVDEQAR FGGVVPEIAS 70 80 90 100 110 120 RAHLEALGPT IRCALAAAGL TGSAKPDVVA ATIGPGLAGA LLVGVAAAKA YSAAWGVPFY 130 140 150 160 170 180 AVNHLGGHLA ADVYEHGPLP ECVALLVSGG HTHLLQVRSL GAPIVELGST VDDAAGEAYD 190 200 210 220 230 240 KVARLLGLGY PGGKVLDDLA RTGDRDAIVF PRGMTGPADD LNAFSFSGLK TAVARYVESH 250 260 270 280 290 300 PDALPADVAA GFQEAVADVL TMKAVRAATG LGVSTLLIVG GVAANSRLRE LAAQRCAAAG 310 320 330 340 350 LMLRIPGPRF CTDNGAMIAA FAAHLLAAAA PPSPLDVPSD PGLPVVKRQI N

References

[1]

"Comparative genomic and phylogeographic analysis of Mycobacterium leprae." Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L. , Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T. Nat. Genet. 41:1282-1289(2009) [PubMed: 19881526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211192 Genomic DNA. Translation: CAR70472.1.
RefSeq	YP_002503002.1. NC_011896.1.
3D structure databases
ProteinModelPortal	B8ZUD0.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZUD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000087254; EBMYCP00000081491; EBMYCG00000087500.
GeneID	7326417.
GenomeReviews	Gene locus MLBr00379 in contig FM211192_GR.
PATRIC	18040806. VBIMycLep121698_0636.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017447.
HOGENOM	HBG304663.
OMA	PLYGVNH.
ProtClustDB	PRK09604.
Family and domain databases
HAMAP	MF_01445. gcp. [Tree]
InterPro	IPR022450. Pept_M22_O-sialoglycopept. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR03723. Bact_gcp. 1 hit. TIGR00329. Gcp_kae1. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8ZUD0_MYCLB

Accession

Primary (citable) accession number: B8ZUD0

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)