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B8ZUA0 (PSD_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:MLBr00311
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Phosphatidylserine decarboxylase beta chain By similarity
PRO_1000192902
Chain212 – 24332Phosphatidylserine decarboxylase alpha chain By similarity
PRO_1000192903

Sites

Site211 – 2122Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2121Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
B8ZUA0 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 4A88C7C59294580E

FASTA24325,523
        10         20         30         40         50         60 
MARRPRAESS KEGPAHLLEL VRSAVPPVHS AGHPFISAGL AVTSAGAVGQ VVTGRDLRWL 

        70         80         90        100        110        120 
RRVGLLAASA CAVFFRHPSR VPPTRAGVVV APADGMICVI DSATPPAELS MGNMSLPRVS 

       130        140        150        160        170        180 
IFLSLLDVHV QRAPISGEVI AVQYQPGRFG AADLAPASTE NERTSVRIRT AGGTEVVVVQ 

       190        200        210        220        230        240 
IAGLLARRIV CYAHIGDKLT IGDTYGLIRF GSRLDTYLPP GTEPVVQVGQ RAVAGETVLA 


DLT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR70404.1.
RefSeqYP_002502972.1. NC_011896.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZUA0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000087037; EBMYCP00000082837; EBMYCG00000087361.
GeneID7325019.
GenomeReviewsGene locus MLBr00311 in contig FM211192_GR.
PATRIC18040520. VBIMycLep121698_0493.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017584.
HOGENOMHBG541103.
OMAIFMSVFN.
ProtClustDBPRK05305.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_MYCLB
AccessionPrimary (citable) accession number: B8ZUA0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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