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B8ZU62 (PTH_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29
Gene names
Name:pth
Ordered Locus Names:MLBr00244
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083

Catalytic activity

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083

Subunit structure

Monomer By similarity. HAMAP MF_00083

Subcellular location

Cytoplasm By similarity HAMAP MF_00083.

Sequence similarities

Belongs to the PTH family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaminoacyl-tRNA hydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Peptidyl-tRNA hydrolase HAMAP MF_00083
PRO_1000118402

Sequences

Sequence LengthMass (Da)Tools
B8ZU62 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 095F4E38FD63361F

FASTA19921,438
        10         20         30         40         50         60 
MAEPTLASGW YPRLVVGLGN PGKNYGRTRH NVGFMVANLL AVRLGSKFEV HKRSGADVVN 

        70         80         90        100        110        120 
GRLAGCSMLV AKPRNYMNES GQQVGLLAKL YSVTPADIII VHDDLDLDFG RIRLKLGGGE 

       130        140        150        160        170        180 
GGHNGLRSVA AALGTKDFQR VRIGIGRPTG RKDPASFVLE NFTTAERMQV PTICKRAADA 

       190 
TELLVGLGLE PAQNHVHAW

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR70337.1.
RefSeqYP_002502934.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZU62.
SMRB8ZU62. Positions 12-199.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZU62.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000087132; EBMYCP00000081434; EBMYCG00000086561.
GeneID7326329.
GenomeReviewsGene locus MLBr00244 in contig FM211192_GR.
PATRIC18040278. VBIMycLep121698_0374.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017462.
HOGENOMHBG610927.
OMAIKFKTGG.
ProtClustDBPRK05426.

Family and domain databases

HAMAPMF_00083. Pept_tRNA_hydro_bact.
[Tree]
InterProIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
PANTHERPTHR17224. Pept_tRNA_hydro. 1 hit.
PfamPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMSSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMsTIGR00447. Pth. 1 hit.
PROSITEPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTH_MYCLB
AccessionPrimary (citable) accession number: B8ZU62
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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