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B8ZU49 (B8ZU49_MYCLB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pantothenate synthetase HAMAP MF_00158
Short name=PS HAMAP MF_00158
EC=6.3.2.1 HAMAP MF_00158
Alternative name(s):
Pantoate--beta-alanine ligase HAMAP MF_00158
Pantoate-activating enzyme HAMAP MF_00158
Gene names
Name:panC HAMAP MF_00158 EMBL CAR70323.1
Ordered Locus Names:MLBr00230
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_00158

Subunit structure

Homodimer By similarity. HAMAP MF_00158

Subcellular location

Cytoplasm By similarity HAMAP MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP MF_00158

Sequence similarities

Belongs to the pantothenate synthetase family. HAMAP MF_00158

Ontologies

Keywords
   Biological processPantothenate biosynthesis HAMAP MF_00158
   Cellular componentCytoplasm HAMAP MF_00158
   LigandATP-binding HAMAP MF_00158
Nucleotide-binding
   Molecular functionLigase HAMAP MF_00158 EMBL CAR70323.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpantothenate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantoate-beta-alanine ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding43 – 508ATP By similarity HAMAP MF_00158
Nucleotide binding161 – 1644ATP By similarity HAMAP MF_00158
Nucleotide binding198 – 2014ATP By similarity HAMAP MF_00158

Sites

Active site501Proton donor By similarity HAMAP MF_00158
Binding site751Beta-alanine By similarity HAMAP MF_00158
Binding site751Pantoate By similarity HAMAP MF_00158
Binding site1671Pantoate By similarity HAMAP MF_00158
Binding site1901ATP; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00158

Sequences

Sequence LengthMass (Da)Tools
B8ZU49 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 0209C216EB26A712

FASTA31333,586
        10         20         30         40         50         60 
MTNSRQPAFN PGELNVYSTP RDVTNVSSAL RHTGRRVMLV PTMGALHNGH LALVRAAKRV 

        70         80         90        100        110        120 
PGSVVVVSIF VNPLQFGAAE DLDTYPCTFD DDLALLRAED VEIVFTPTAA AMYPHGLRTT 

       130        140        150        160        170        180 
VRPGALAFEL EGGPRPNHFD GVLTVVLKLL QIVRPDRVFF GEKDYQQLVL IRQMVADLNV 

       190        200        210        220        230        240 
DVVVVGVPTV REVDGLAMSS RNCYLDPVQR DLAAALSAAL TAGAHAATGG AQAALDAARA 

       250        260        270        280        290        300 
VLDATPGLVV DYVELRDAGL GPMRDNTFGR LLVAARLGAT RLLDNISIEI GNFSGIASPD 

       310 
ECRVEHAQTP WMK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR70323.1.
RefSeqYP_002502921.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZU49.
SMRB8ZU49. Positions 7-294.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZU49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000085594; EBMYCP00000082062; EBMYCG00000087046.
GeneID7326323.
GenomeReviewsGene locus MLBr00230 in contig FM211192_GR.
PATRIC18040248. VBIMycLep121698_0359.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016962.
HOGENOMHBG428839.
OMALNMPIQI.
ProtClustDBPRK00380.

Family and domain databases

HAMAPMF_00158. PanC.
[Tree]
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHERPTHR21299:SF1. Pantoate_ligase. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00018. PanC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8ZU49_MYCLB
AccessionPrimary (citable) accession number: B8ZU49
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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