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B8ZU42 (GCH1_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:MLBr00223
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000124923

Sites

Metal binding931Zinc By similarity
Metal binding961Zinc By similarity
Metal binding1661Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
B8ZU42 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 1F0CE25354715C4B

FASTA20522,531
        10         20         30         40         50         60 
MALLDLGLES TAVPRIRVFD QQRAEAAIRE LLYAIGEDPD REGLADTPAR VARACRELFS 

        70         80         90        100        110        120 
GLYTDPQTVL NTMFDEEHNE LVIVKEIPMY STCEHHLVSF HGVAHIGYLP GADGRVTGLS 

       130        140        150        160        170        180 
KIARLVDLYA KRPQVQERLT SQIADALVSK LDPRGVIIVV EAEHLCMAMR GVRKPGAITT 

       190        200 
TSAVRGQFKT DAASRAEALG LILRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM211192 Genomic DNA. Translation: CAR70316.1.
RefSeqYP_002502914.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZU42.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING561304.MLBr_00223.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR70316; CAR70316; MLBr00223.
GeneID7325313.
KEGGmlb:MLBr_00223.
PATRIC18040232. VBIMycLep121698_0351.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
KOK01495.
OMARKPGAVT.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycMLEP561304:GJP6-231-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_MYCLB
AccessionPrimary (citable) accession number: B8ZU42
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways