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B8ZU05

- PUR9_MYCLB

UniProt

B8ZU05 - PUR9_MYCLB

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciMLEP561304:GJP6-167-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:MLBr00161
    OrganismiMycobacterium leprae (strain Br4923)
    Taxonomic identifieri561304 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006900: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Bifunctional purine biosynthesis protein PurHPRO_1000122966Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi561304.MLBr_00161.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZU05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    KOiK00602.
    OMAiPEECIEK.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8ZU05-1 [UniParc]FASTAAdd to Basket

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    MSSDGERDMA RKPIRRALIS VYDKTGLIDL AQGLNAAGVD IVSTGSTAKA    50
    IADQGIAVTP VEELTGFPEV LDGRVKTLHP RVHAGLLADL RKPEHAAALE 100
    QLGIEAFELV VVNLYPFSQT VKSGATVDEC VEQIDIGGSS MVRAAAKNHP 150
    SVAVVTDPLG YVGVLAAVQG GGFTLAERKM LASMAFQHIA EYEIAVASWM 200
    QSTLAPEQPP TAFPQWFGRS WRRSAILRYG ENPHQQAALY SDPSACPGLA 250
    QAEQLHGKNM SYNNFTDADA AWRAAFDHEQ SCVAIIKHAN PCGIAISSLS 300
    VADAHRKAHE CDPLSAYGGV IAANTEVSLE MAEYVSTIFT EVIVAPSYAP 350
    GAVDVLSCKK NVRVLVASAP LRGGSELRPV SGGLLIQQPD QLDTAGDNPA 400
    NWTLATGSPA GPATLTDLVF AWRACRAVKS NAIVIAADGA TIGVGMGQVN 450
    RVDAARLAVE RGGDRVRGAV VASDAFFPFA DGLQTLAAAG VTAIVHPGGS 500
    VRDAEVTAAA TKAGVTLYLT GVRHFVH 527
    Length:527
    Mass (Da):55,230
    Last modified:March 3, 2009 - v1
    Checksum:iD247DEBE93F33117
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70254.1.
    RefSeqiYP_002502877.1. NC_011896.1.

    Genome annotation databases

    EnsemblBacteriaiCAR70254; CAR70254; MLBr00161.
    GeneIDi7325042.
    KEGGimlb:MLBr_00161.
    PATRICi18040013. VBIMycLep121698_0244.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70254.1 .
    RefSeqi YP_002502877.1. NC_011896.1.

    3D structure databases

    ProteinModelPortali B8ZU05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561304.MLBr_00161.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR70254 ; CAR70254 ; MLBr00161 .
    GeneIDi 7325042.
    KEGGi mlb:MLBr_00161.
    PATRICi 18040013. VBIMycLep121698_0244.

    Phylogenomic databases

    eggNOGi COG0138.
    KOi K00602.
    OMAi PEECIEK.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci MLEP561304:GJP6-167-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Br4923.

    Entry informationi

    Entry nameiPUR9_MYCLB
    AccessioniPrimary (citable) accession number: B8ZU05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3