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B8ZU05 (PUR9_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:MLBr00161
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000122966

Sequences

Sequence LengthMass (Da)Tools
B8ZU05 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: D247DEBE93F33117

FASTA52755,230
        10         20         30         40         50         60 
MSSDGERDMA RKPIRRALIS VYDKTGLIDL AQGLNAAGVD IVSTGSTAKA IADQGIAVTP 

        70         80         90        100        110        120 
VEELTGFPEV LDGRVKTLHP RVHAGLLADL RKPEHAAALE QLGIEAFELV VVNLYPFSQT 

       130        140        150        160        170        180 
VKSGATVDEC VEQIDIGGSS MVRAAAKNHP SVAVVTDPLG YVGVLAAVQG GGFTLAERKM 

       190        200        210        220        230        240 
LASMAFQHIA EYEIAVASWM QSTLAPEQPP TAFPQWFGRS WRRSAILRYG ENPHQQAALY 

       250        260        270        280        290        300 
SDPSACPGLA QAEQLHGKNM SYNNFTDADA AWRAAFDHEQ SCVAIIKHAN PCGIAISSLS 

       310        320        330        340        350        360 
VADAHRKAHE CDPLSAYGGV IAANTEVSLE MAEYVSTIFT EVIVAPSYAP GAVDVLSCKK 

       370        380        390        400        410        420 
NVRVLVASAP LRGGSELRPV SGGLLIQQPD QLDTAGDNPA NWTLATGSPA GPATLTDLVF 

       430        440        450        460        470        480 
AWRACRAVKS NAIVIAADGA TIGVGMGQVN RVDAARLAVE RGGDRVRGAV VASDAFFPFA 

       490        500        510        520 
DGLQTLAAAG VTAIVHPGGS VRDAEVTAAA TKAGVTLYLT GVRHFVH

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR70254.1.
RefSeqYP_002502877.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZU05.
ModBaseSearch...

Protein-protein interaction databases

STRING561304.MLBr_00161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR70254; CAR70254; MLBr00161.
GeneID7325042.
KEGGmlb:MLBr_00161.
PATRIC18040013. VBIMycLep121698_0244.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
KOK00602.
OMADLLFAWK.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycMLEP561304:GJP6-167-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF53927. Cytidine_deaminase-like. 1 hit.
SSF52335. MGS-like_dom. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_MYCLB
AccessionPrimary (citable) accession number: B8ZU05
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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