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B8ZU05

- PUR9_MYCLB

UniProt

B8ZU05 - PUR9_MYCLB

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, MLBr00161
Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-167-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:MLBr00161
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000122966Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561304.MLBr_00161.

Structurei

3D structure databases

ProteinModelPortaliB8ZU05.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiPEECIEK.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZU05-1 [UniParc]FASTAAdd to Basket

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MSSDGERDMA RKPIRRALIS VYDKTGLIDL AQGLNAAGVD IVSTGSTAKA    50
IADQGIAVTP VEELTGFPEV LDGRVKTLHP RVHAGLLADL RKPEHAAALE 100
QLGIEAFELV VVNLYPFSQT VKSGATVDEC VEQIDIGGSS MVRAAAKNHP 150
SVAVVTDPLG YVGVLAAVQG GGFTLAERKM LASMAFQHIA EYEIAVASWM 200
QSTLAPEQPP TAFPQWFGRS WRRSAILRYG ENPHQQAALY SDPSACPGLA 250
QAEQLHGKNM SYNNFTDADA AWRAAFDHEQ SCVAIIKHAN PCGIAISSLS 300
VADAHRKAHE CDPLSAYGGV IAANTEVSLE MAEYVSTIFT EVIVAPSYAP 350
GAVDVLSCKK NVRVLVASAP LRGGSELRPV SGGLLIQQPD QLDTAGDNPA 400
NWTLATGSPA GPATLTDLVF AWRACRAVKS NAIVIAADGA TIGVGMGQVN 450
RVDAARLAVE RGGDRVRGAV VASDAFFPFA DGLQTLAAAG VTAIVHPGGS 500
VRDAEVTAAA TKAGVTLYLT GVRHFVH 527
Length:527
Mass (Da):55,230
Last modified:March 3, 2009 - v1
Checksum:iD247DEBE93F33117
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR70254.1.
RefSeqiYP_002502877.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR70254; CAR70254; MLBr00161.
GeneIDi7325042.
KEGGimlb:MLBr_00161.
PATRICi18040013. VBIMycLep121698_0244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR70254.1 .
RefSeqi YP_002502877.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZU05.
ModBasei Search...

Protein-protein interaction databases

STRINGi 561304.MLBr_00161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR70254 ; CAR70254 ; MLBr00161 .
GeneIDi 7325042.
KEGGi mlb:MLBr_00161.
PATRICi 18040013. VBIMycLep121698_0244.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi PEECIEK.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MLEP561304:GJP6-167-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiPUR9_MYCLB
AccessioniPrimary (citable) accession number: B8ZU05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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