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B8ZTZ5

- G6PI_MYCLB

UniProt

B8ZTZ5 - G6PI_MYCLB

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Protein

Glucose-6-phosphate isomerase

Gene
pgi, MLBr00150
Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei389 – 3891 By similarity
Active sitei515 – 5151 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-156-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:MLBr00150
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Glucose-6-phosphate isomeraseUniRule annotationPRO_1000135535Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561304.MLBr_00150.

Structurei

3D structure databases

ProteinModelPortaliB8ZTZ5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiLITEEVM.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZTZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MTSMQAIPDI TATPAWDALR RHHDEIGATH LRQFFADNPN RGRELVITVG    50
DLYIDYSKHR ITHDTVQLLV DLARAANLEQ RRDQMLAGVH VNTSENRSVL 100
HTALRLPRDT ELIVDGQNVV QDVHAVLDVM GDFTDRLRSG EWTGATGKRI 150
NTVVNIGIGG SDLGPVMVYQ ALRHYADAGI SARFVSNIDP ADLTAKLSDL 200
EPGTTLFIVA SKTFSTLETL TNATAARRWL TDALGEAAVS KHFVAVSTNK 250
RLVKDFGINT ANMFGFWEWV GGRYSVDSAI GLSLMAVVGR ESFADFLSGF 300
HIVDQHFQNA PLESNAPVLL GLIGLWYSDF LGAQSRAVLP YSNDLARFAA 350
YLQQLTMESN GKSTRADGTP VTTNTGEIYW GETGTNGQHA FYQLLHQGTR 400
LVPADFIGFS QPIDDLPTVD GIGSMHDLLM SNFFAQTQVL AFGKTAEEIA 450
AEGTPAEVVP HKVMPGNRPT TSILANRLTP SVLGQLIALY EHQVFTEGVI 500
WGIDSFDQWG VELGKKQAEA LLPVITGNAS PAQQLDSSTD TLVRRYRTER 550
GRTS 554
Length:554
Mass (Da):60,634
Last modified:March 3, 2009 - v1
Checksum:i013E1846AD893EA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR70243.1.
RefSeqiWP_010907561.1. NC_011896.1.
YP_002502867.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR70243; CAR70243; MLBr00150.
GeneIDi7325866.
KEGGimlb:MLBr_00150.
PATRICi18039981. VBIMycLep121698_0228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR70243.1 .
RefSeqi WP_010907561.1. NC_011896.1.
YP_002502867.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZTZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561304.MLBr_00150.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR70243 ; CAR70243 ; MLBr00150 .
GeneIDi 7325866.
KEGGi mlb:MLBr_00150.
PATRICi 18039981. VBIMycLep121698_0228.

Phylogenomic databases

eggNOGi COG0166.
KOi K01810.
OMAi LITEEVM.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
UPA00138 .
BioCyci MLEP561304:GJP6-156-MONOMER.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiG6PI_MYCLB
AccessioniPrimary (citable) accession number: B8ZTZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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