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B8ZTZ5

- G6PI_MYCLB

UniProt

B8ZTZ5 - G6PI_MYCLB

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei389 – 3891UniRule annotation
    Active sitei515 – 5151UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciMLEP561304:GJP6-156-MONOMER.
    UniPathwayiUPA00109; UER00181.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:MLBr00150
    OrganismiMycobacterium leprae (strain Br4923)
    Taxonomic identifieri561304 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006900: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Glucose-6-phosphate isomerasePRO_1000135535Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi561304.MLBr_00150.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZTZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    KOiK01810.
    OMAiLITEEVM.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8ZTZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSMQAIPDI TATPAWDALR RHHDEIGATH LRQFFADNPN RGRELVITVG    50
    DLYIDYSKHR ITHDTVQLLV DLARAANLEQ RRDQMLAGVH VNTSENRSVL 100
    HTALRLPRDT ELIVDGQNVV QDVHAVLDVM GDFTDRLRSG EWTGATGKRI 150
    NTVVNIGIGG SDLGPVMVYQ ALRHYADAGI SARFVSNIDP ADLTAKLSDL 200
    EPGTTLFIVA SKTFSTLETL TNATAARRWL TDALGEAAVS KHFVAVSTNK 250
    RLVKDFGINT ANMFGFWEWV GGRYSVDSAI GLSLMAVVGR ESFADFLSGF 300
    HIVDQHFQNA PLESNAPVLL GLIGLWYSDF LGAQSRAVLP YSNDLARFAA 350
    YLQQLTMESN GKSTRADGTP VTTNTGEIYW GETGTNGQHA FYQLLHQGTR 400
    LVPADFIGFS QPIDDLPTVD GIGSMHDLLM SNFFAQTQVL AFGKTAEEIA 450
    AEGTPAEVVP HKVMPGNRPT TSILANRLTP SVLGQLIALY EHQVFTEGVI 500
    WGIDSFDQWG VELGKKQAEA LLPVITGNAS PAQQLDSSTD TLVRRYRTER 550
    GRTS 554
    Length:554
    Mass (Da):60,634
    Last modified:March 3, 2009 - v1
    Checksum:i013E1846AD893EA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70243.1.
    RefSeqiWP_010907561.1. NC_011896.1.
    YP_002502867.1. NC_011896.1.

    Genome annotation databases

    EnsemblBacteriaiCAR70243; CAR70243; MLBr00150.
    GeneIDi7325866.
    KEGGimlb:MLBr_00150.
    PATRICi18039981. VBIMycLep121698_0228.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70243.1 .
    RefSeqi WP_010907561.1. NC_011896.1.
    YP_002502867.1. NC_011896.1.

    3D structure databases

    ProteinModelPortali B8ZTZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561304.MLBr_00150.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR70243 ; CAR70243 ; MLBr00150 .
    GeneIDi 7325866.
    KEGGi mlb:MLBr_00150.
    PATRICi 18039981. VBIMycLep121698_0228.

    Phylogenomic databases

    eggNOGi COG0166.
    KOi K01810.
    OMAi LITEEVM.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    UPA00138 .
    BioCyci MLEP561304:GJP6-156-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Br4923.

    Entry informationi

    Entry nameiG6PI_MYCLB
    AccessioniPrimary (citable) accession number: B8ZTZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3