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B8ZTZ5 (G6PI_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:MLBr00150
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000135535

Sites

Active site3891 By similarity
Active site5151 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8ZTZ5 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 013E1846AD893EA6

FASTA55460,634
        10         20         30         40         50         60 
MTSMQAIPDI TATPAWDALR RHHDEIGATH LRQFFADNPN RGRELVITVG DLYIDYSKHR 

        70         80         90        100        110        120 
ITHDTVQLLV DLARAANLEQ RRDQMLAGVH VNTSENRSVL HTALRLPRDT ELIVDGQNVV 

       130        140        150        160        170        180 
QDVHAVLDVM GDFTDRLRSG EWTGATGKRI NTVVNIGIGG SDLGPVMVYQ ALRHYADAGI 

       190        200        210        220        230        240 
SARFVSNIDP ADLTAKLSDL EPGTTLFIVA SKTFSTLETL TNATAARRWL TDALGEAAVS 

       250        260        270        280        290        300 
KHFVAVSTNK RLVKDFGINT ANMFGFWEWV GGRYSVDSAI GLSLMAVVGR ESFADFLSGF 

       310        320        330        340        350        360 
HIVDQHFQNA PLESNAPVLL GLIGLWYSDF LGAQSRAVLP YSNDLARFAA YLQQLTMESN 

       370        380        390        400        410        420 
GKSTRADGTP VTTNTGEIYW GETGTNGQHA FYQLLHQGTR LVPADFIGFS QPIDDLPTVD 

       430        440        450        460        470        480 
GIGSMHDLLM SNFFAQTQVL AFGKTAEEIA AEGTPAEVVP HKVMPGNRPT TSILANRLTP 

       490        500        510        520        530        540 
SVLGQLIALY EHQVFTEGVI WGIDSFDQWG VELGKKQAEA LLPVITGNAS PAQQLDSSTD 

       550 
TLVRRYRTER GRTS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR70243.1.
RefSeqYP_002502867.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZTZ5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZTZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000085362; EBMYCP00000082015; EBMYCG00000086643.
GeneID7325866.
GenomeReviewsGene locus MLBr00150 in contig FM211192_GR.
PATRIC18039981. VBIMycLep121698_0228.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016991.
HOGENOMHBG352954.
OMANSLPAWT.
ProtClustDBPRK00179.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
Gene3DG3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_MYCLB
AccessionPrimary (citable) accession number: B8ZTZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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