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B8ZTI4

- TRMB_MYCLB

UniProt

B8ZTI4 - TRMB_MYCLB

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611S-adenosyl-L-methionineUniRule annotation
Binding sitei86 – 861S-adenosyl-L-methionineUniRule annotation
Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation
Active sitei136 – 1361By similarity
Binding sitei136 – 1361S-adenosyl-L-methionineUniRule annotation
Binding sitei140 – 1401SubstrateUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-2679-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:MLBr02622
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230tRNA (guanine-N(7)-)-methyltransferasePRO_1000149659Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561304.MLBr_02622.

Structurei

3D structure databases

ProteinModelPortaliB8ZTI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 2114Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiLHIATDH.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZTI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARHLPATAF RKRRSALSHA QRQTWERLWP EIGISAVSQT RSAERLDTGA
60 70 80 90 100
WFGRSTLVVL EVGCGSGTAT LAMAQHEPDI DVIAVEVYRR GLAQLLCAID
110 120 130 140 150
RDQVHNIRMI HGNALYVLQY LIAPRSLTGV RVFFPDPWPK VRHHKRRFLQ
160 170 180 190 200
PATVELIADR LLPGGVLHTA TDHPDYAKQI AKFGDGEPLL SRADGRTQLP
210 220 230
ISTVRPTTKY ETKAQHAGNV VTELIWKKRS
Length:230
Mass (Da):25,821
Last modified:March 3, 2009 - v1
Checksum:i082DD06A64624D7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR72722.1.
RefSeqiWP_010908999.1. NC_011896.1.
YP_002504310.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR72722; CAR72722; MLBr02622.
GeneIDi7325534.
KEGGimlb:MLBr_02622.
PATRICi18049697. VBIMycLep121698_5047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR72722.1 .
RefSeqi WP_010908999.1. NC_011896.1.
YP_002504310.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZTI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561304.MLBr_02622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR72722 ; CAR72722 ; MLBr02622 .
GeneIDi 7325534.
KEGGi mlb:MLBr_02622.
PATRICi 18049697. VBIMycLep121698_5047.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi LHIATDH.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MLEP561304:GJP6-2679-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiTRMB_MYCLB
AccessioniPrimary (citable) accession number: B8ZTI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3