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B8ZTH4 (B8ZTH4_MYCLB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase HAMAP MF_00012
Short name=DAD HAMAP MF_00012
EC=4.2.1.9 HAMAP MF_00012
Gene names
Name:ilvD HAMAP MF_00012 EMBL CAR72708.1
Ordered Locus Names:MLBr02608
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP MF_00012

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family. HAMAP MF_00012

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1261Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012
Metal binding2031Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012

Sequences

Sequence LengthMass (Da)Tools
B8ZTH4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 23E5782F003536B5

FASTA56458,783
        10         20         30         40         50         60 
MMPPDIKPRS RDVTDGLEKA AARGMLRAVG MNDDDFAKAQ IGVASSWNEI TPCNLSLDRL 

        70         80         90        100        110        120 
AKAVKEGVFS AGGYPLEFGT ISVSDGISMG HQGMHFSLVS REVIADSVET VMQAERLDGS 

       130        140        150        160        170        180 
VLLAGCDKSL PGMLMAAARL DLASVFLYAG SILPGRTKLS DGTEHEVTLI DAFEAVGACS 

       190        200        210        220        230        240 
RGLMPRADVD AIERAICPGE GACGGMYTAN TMASAAEALG MSLPGSAAPP ATDRRRDGFA 

       250        260        270        280        290        300 
RRSGQAVIEL LRRGITARDI LTKEAFENAI AVVMAFGGST NAILHLLAIA HEADVTLSLE 

       310        320        330        340        350        360 
DFSRIGFKVP HIADVKPFGR HVMFDVDHIG GVPVVMKALL DAGLLHGDCL TVTGQTMAEN 

       370        380        390        400        410        420 
LASIAPPDPD GQVIRTLHNP IHPTGGITIL RGSLAPDGAV VKTAGLDSDV FEGTARVFDG 

       430        440        450        460        470        480 
ERAALDALKD GTIAKGDVVV IRYEGPKGGP GMREMLAITG AIKGAGLGKD VLLLTDGRFS 

       490        500        510        520        530        540 
GGTTGFCVGH IAPEAVEAGP IAFLRDGDRV LLDVVGCSLD VLVDPVEFSS RKKDFIPPAP 

       550        560 
RYTTGVLAKY VKLVSSATVG AVCG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR72708.1.
RefSeqYP_002504300.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZTH4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZTH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000086672; EBMYCP00000082714; EBMYCG00000085136.
GeneID7325521.
GenomeReviewsGene locus MLBr02608 in contig FM211192_GR.
PATRIC18049653. VBIMycLep121698_5025.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016366.
HOGENOMHBG671001.
OMANMPGAMI.
ProtClustDBPRK00911.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8ZTH4_MYCLB
AccessionPrimary (citable) accession number: B8ZTH4
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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