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B8ZSY2

- MEND_MYCLB

UniProt

B8ZSY2 - MEND_MYCLB

Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotation

    Catalytic activityi

    Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

    Cofactori

    Magnesium or manganese.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciMLEP561304:GJP6-2320-MONOMER.
    UniPathwayiUPA00079; UER00164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
    Short name:
    SEPHCHC synthaseUniRule annotation
    Alternative name(s):
    Menaquinone biosynthesis protein MenDUniRule annotation
    Gene namesi
    Name:menDUniRule annotation
    Ordered Locus Names:MLBr02270
    OrganismiMycobacterium leprae (strain Br4923)
    Taxonomic identifieri561304 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006900: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5565562-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthasePRO_1000187082Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi561304.MLBr_02270.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZSY2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1165.
    KOiK02551.
    OMAiSEIWNIT.
    OrthoDBiEOG6NWBQW.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01659. MenD.
    InterProiIPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    [Graphical view]
    PfamiPF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004983. MenD. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00173. menD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8ZSY2-1 [UniParc]FASTAAdd to Basket

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    MNPSTTQARV VVDELIRGGV RDVVLCPGSR NAPLAFALQD ADHAGRIRLH    50
    VRIDERTAGY LAIGLAVAAG APVCVAMTSG TAVANLGPAV VEANYARVPL 100
    IVLSANRPYE LLGTGANQTM EQLGYFGTQV RAAISLGLAE DAPERLDSLN 150
    ATWRSATCRV LVAATGSRTA NAGPVQFDIP LREPLIPDPE PHGAITPQGR 200
    PGGKPWTYIP QVTFDQPLEI DLSADTVVIA GHGAGVHPNL TELPIVAEPT 250
    APFGPYRPYP LHPLALPLLH PKQVIMLGRP TLHRPVSALL ADPQVPVYAL 300
    TTGPCWPDVS GNSQAAGTRA VTTGTPHPAW LQRCAEMNQH AISTVRSQLA 350
    AHPLITGLHV AAAVADALRP GDQLVLGASN PVRDMALVGL STDGIQVRSN 400
    RGVAGIDGTV STAIGAALAY ERSPGYAGST DRPARTVALI GDLAFVHDSS 450
    GLLIGPTEPT PQQLKIVVSN DNGGGIFELL EQGDPRLSAV SSRIFGTPHD 500
    VDVGALCRAY HVEGRQIEVD KLREALDEPG VGMRVLEVKA DRSSLRQLHA 550
    AITATL 556
    Length:556
    Mass (Da):58,351
    Last modified:March 3, 2009 - v1
    Checksum:i63646C2CCD41D1F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR72368.1.
    RefSeqiWP_010908798.1. NC_011896.1.
    YP_002504108.1. NC_011896.1.

    Genome annotation databases

    EnsemblBacteriaiCAR72368; CAR72368; MLBr02270.
    GeneIDi7324873.
    KEGGimlb:MLBr_02270.
    PATRICi18048313. VBIMycLep121698_4359.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR72368.1 .
    RefSeqi WP_010908798.1. NC_011896.1.
    YP_002504108.1. NC_011896.1.

    3D structure databases

    ProteinModelPortali B8ZSY2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561304.MLBr_02270.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR72368 ; CAR72368 ; MLBr02270 .
    GeneIDi 7324873.
    KEGGi mlb:MLBr_02270.
    PATRICi 18048313. VBIMycLep121698_4359.

    Phylogenomic databases

    eggNOGi COG1165.
    KOi K02551.
    OMAi SEIWNIT.
    OrthoDBi EOG6NWBQW.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00164 .
    BioCyci MLEP561304:GJP6-2320-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01659. MenD.
    InterProi IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    [Graphical view ]
    Pfami PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004983. MenD. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00173. menD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Br4923.

    Entry informationi

    Entry nameiMEND_MYCLB
    AccessioniPrimary (citable) accession number: B8ZSY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3