B8ZSV0 (B8ZSV0_MYCLB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370

Gene names

Name:	purM EMBL CAR72302.1
Ordered Locus Names:	MLBr02205

Organism

Mycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]

Taxonomic identifier

561304 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733
Subcellular location	Cytoplasm By similarity SAAS SAAS004733.
Sequence similarities	Belongs to the AIR synthase family. RuleBase RU004370

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS004733
Cellular component	Cytoplasm SAAS SAAS004733
Ligand	ATP-binding SAAS SAAS004733 Nucleotide-binding
Molecular function	Ligase RuleBase RU004370 SAAS SAAS004733
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8ZSV0 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: A51DD47CB3BEABD0	FASTA	364	38,352
	10 20 30 40 50 60 MMDPGKSPGG QLGNHGITYA STGVDIEAGD RSVELFKPMA VKAIRTEVLG GLGGFAGLFA 70 80 90 100 110 120 LRSGYREPVL AASTDGVGTK LAVAQAMDKH DTVGLDLVAM VVDDLVVCGA EPLFLQDYIA 130 140 150 160 170 180 VGRTVPERLS AIVDGIAEGC MLAGCALLGG ETAEHPGLME VDHYDIAATG VGVVEADDTL 190 200 210 220 230 240 GPDRVKPGDV IIALRSSGLH SNGYSLARSV LLEIDRMNLA GYVEEFGRTL GEELLEPTRI 250 260 270 280 290 300 YAKDCLALAA ETHVRTFCHV TGGGLAGNLQ RVIPHGLVAE VDRGTWTPAP VFAMIAQRGR 310 320 330 340 350 360 VAREEMEKTF NMGVGMIAVV APEDTDRALA ILTARHLDCW VLGTVCKGSK VGPRAKLVGQ HPRF

References

[1]

"Comparative genomic and phylogeographic analysis of Mycobacterium leprae." Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L. , Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T. Nat. Genet. 41:1282-1289(2009) [PubMed: 19881526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211192 Genomic DNA. Translation: CAR72302.1.
RefSeq	YP_002504076.1. NC_011896.1.
3D structure databases
ProteinModelPortal	B8ZSV0.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZSV0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000087729; EBMYCP00000082156; EBMYCG00000086549.
GeneID	7324830.
GenomeReviews	Gene locus MLBr02205 in contig FM211192_GR.
PATRIC	18047985. VBIMycLep121698_4196.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016383.
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8ZSV0_MYCLB

Accession

Primary (citable) accession number: B8ZSV0

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)