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B8ZSN5

- GCSP_MYCLB

UniProt

B8ZSN5 - GCSP_MYCLB

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-2115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:MLBr02072
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Glycine dehydrogenase (decarboxylating)PRO_1000147967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi561304.MLBr_02072.

Structurei

3D structure databases

ProteinModelPortaliB8ZSN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiDSHRNIC.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZSN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVPNSSNKQ TCFTARHIGP NSEDVATMLA VIGVESLDDL AAKAVPSDIL
60 70 80 90 100
DNVTDTGVAP GLDRLPPPAT ESETLAELGA LARANTVAVS MIGQGYYDTL
110 120 130 140 150
TPAVLSRNIL ENPAWYTPYT PYQPEISQGR LEALLNFQTL VSDLTGLEIA
160 170 180 190 200
NASMLDEGTA AAEAMTLMYR AARSTASRVV VDVDVFAQTV AVFATRAKPL
210 220 230 240 250
GIDIVVADLR EGLPDGEFFG VITQLPGASG RITDWTALIA QAHSRGALVA
260 270 280 290 300
VGADLLALTL ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLALHTKHA
310 320 330 340 350
RQLPGRLVGV SVDSDGTPAY RLALQTREQH IRRDKATSNI CTAQVLLAVM
360 370 380 390 400
AAMYASYHGA EGLTGIARRV HAQARALAAG LSAAGVEVVH QAFFDTVLAR
410 420 430 440 450
VPGRTVQIQG AAKERGINVW LVDGDHVSVA CDEATTDEHI TAVLAAFAAT
460 470 480 490 500
PARASFAGPD IATRTSAFLT HPTFTKYRTE TSMMRYLRAL ADKDIALDRS
510 520 530 540 550
MIPLGSCTMK LNAAAEMESI TWQEFTRQHP FAPVSDTPGL RRLISDLESW
560 570 580 590 600
LVQITGYDAV SLQPNAGSQG EYAGLLAIHD YHVSRGEPHR NVCLIPSSAH
610 620 630 640 650
GTNAASAALV GMRVVVVGCH DNGDVDLDDL RIKLSEHANR LSVLMITYPS
660 670 680 690 700
THGVYEHDIA EICAAVHDAG GQVYVDGANL NALVGLARPG KFGGDVSHLN
710 720 730 740 750
LHKTFCIPHG GGGPGVGPVA VRSHLVSFLP GHPFAPELPQ GQPVSSAPYG
760 770 780 790 800
SASLLPITWA YIRMMGADGL RTASLTAIAS ANYIARRLDK YFPVLYTGEN
810 820 830 840 850
GMVAHECILD LRPITKSVGV TVDDVAKRLA DYGFHAPTMS FPVPGTLMVE
860 870 880 890 900
PTESESLAEI DAFCEAMIAI RGEIARVGAG EWSVEDNPLR GAPHTAECLL
910 920 930 940 950
ASDWDHPYTR EEAAYPLGKA FRPKVWPPVR RIDGVYGDRN LVCSCLPVEA

FV
Length:952
Mass (Da):101,283
Last modified:March 3, 2009 - v1
Checksum:iADC68B6265C3D8FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR72169.1.
RefSeqiWP_010908701.1. NC_011896.1.
YP_002504011.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR72169; CAR72169; MLBr02072.
GeneIDi7325141.
KEGGimlb:MLBr_02072.
PATRICi18047427. VBIMycLep121698_3922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR72169.1 .
RefSeqi WP_010908701.1. NC_011896.1.
YP_002504011.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZSN5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561304.MLBr_02072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR72169 ; CAR72169 ; MLBr02072 .
GeneIDi 7325141.
KEGGi mlb:MLBr_02072.
PATRICi 18047427. VBIMycLep121698_3922.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi DSHRNIC.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci MLEP561304:GJP6-2115-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiGCSP_MYCLB
AccessioniPrimary (citable) accession number: B8ZSN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3