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B8ZSN5

- GCSP_MYCLB

UniProt

B8ZSN5 - GCSP_MYCLB

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, MLBr02072
Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-2115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:MLBr02072
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000147967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi561304.MLBr_02072.

Structurei

3D structure databases

ProteinModelPortaliB8ZSN5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiDSHRNIC.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZSN5-1 [UniParc]FASTAAdd to Basket

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MSVPNSSNKQ TCFTARHIGP NSEDVATMLA VIGVESLDDL AAKAVPSDIL    50
DNVTDTGVAP GLDRLPPPAT ESETLAELGA LARANTVAVS MIGQGYYDTL 100
TPAVLSRNIL ENPAWYTPYT PYQPEISQGR LEALLNFQTL VSDLTGLEIA 150
NASMLDEGTA AAEAMTLMYR AARSTASRVV VDVDVFAQTV AVFATRAKPL 200
GIDIVVADLR EGLPDGEFFG VITQLPGASG RITDWTALIA QAHSRGALVA 250
VGADLLALTL ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLALHTKHA 300
RQLPGRLVGV SVDSDGTPAY RLALQTREQH IRRDKATSNI CTAQVLLAVM 350
AAMYASYHGA EGLTGIARRV HAQARALAAG LSAAGVEVVH QAFFDTVLAR 400
VPGRTVQIQG AAKERGINVW LVDGDHVSVA CDEATTDEHI TAVLAAFAAT 450
PARASFAGPD IATRTSAFLT HPTFTKYRTE TSMMRYLRAL ADKDIALDRS 500
MIPLGSCTMK LNAAAEMESI TWQEFTRQHP FAPVSDTPGL RRLISDLESW 550
LVQITGYDAV SLQPNAGSQG EYAGLLAIHD YHVSRGEPHR NVCLIPSSAH 600
GTNAASAALV GMRVVVVGCH DNGDVDLDDL RIKLSEHANR LSVLMITYPS 650
THGVYEHDIA EICAAVHDAG GQVYVDGANL NALVGLARPG KFGGDVSHLN 700
LHKTFCIPHG GGGPGVGPVA VRSHLVSFLP GHPFAPELPQ GQPVSSAPYG 750
SASLLPITWA YIRMMGADGL RTASLTAIAS ANYIARRLDK YFPVLYTGEN 800
GMVAHECILD LRPITKSVGV TVDDVAKRLA DYGFHAPTMS FPVPGTLMVE 850
PTESESLAEI DAFCEAMIAI RGEIARVGAG EWSVEDNPLR GAPHTAECLL 900
ASDWDHPYTR EEAAYPLGKA FRPKVWPPVR RIDGVYGDRN LVCSCLPVEA 950
FV 952
Length:952
Mass (Da):101,283
Last modified:March 3, 2009 - v1
Checksum:iADC68B6265C3D8FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR72169.1.
RefSeqiYP_002504011.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR72169; CAR72169; MLBr02072.
GeneIDi7325141.
KEGGimlb:MLBr_02072.
PATRICi18047427. VBIMycLep121698_3922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR72169.1 .
RefSeqi YP_002504011.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZSN5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561304.MLBr_02072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR72169 ; CAR72169 ; MLBr02072 .
GeneIDi 7325141.
KEGGi mlb:MLBr_02072.
PATRICi 18047427. VBIMycLep121698_3922.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi DSHRNIC.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci MLEP561304:GJP6-2115-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiGCSP_MYCLB
AccessioniPrimary (citable) accession number: B8ZSN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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