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B8ZSG0 (B8ZSG0_MYCLB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:lytB2 EMBL CAR72035.1
Synonyms:ispH HAMAP MF_00191
Ordered Locus Names:MLBr01938
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B8ZSG0 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 78961921ED619400

FASTA33536,542
        10         20         30         40         50         60 
MKGMPPTVNM GIPGASRSIV ENLKRKRVLL AEPRGYCAGV DRAVETVERS LRKYGPPVYV 

        70         80         90        100        110        120 
RHEIVHNRHV VETLERAGAV FVEETDYVPE GAIVIFSAHG VAPTVYAAAA ERNLRTIDAT 

       130        140        150        160        170        180 
CPLVTKVHNE VKRFARNDYD ILLIGHEGHE EVIATAGEAP THVQLVDGLA AVQQVVVRDE 

       190        200        210        220        230        240 
NKVVWLSQTT LSVDETMRIV ERLRQRFPKL QDPPSDDICY ATQNRQVAVK AMAPECELVI 

       250        260        270        280        290        300 
VVGSRNSSNS VRLVEVAMGS GAGAAYLVDW AKDIDPAWLA GVTTVGVTSG ASVPDILVQG 

       310        320        330 
VLKWLAERGY DVVQSVTTAN EALVFALPRE IRSAH

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR72035.1.
RefSeqYP_002503936.1. NC_011896.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZSG0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000087643; EBMYCP00000082050; EBMYCG00000086765.
GeneID7325548.
GenomeReviewsGene locus MLBr01938 in contig FM211192_GR.
PATRIC18046972. VBIMycLep121698_3695.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016858.
HOGENOMHBG335228.
OMAAMAPECD.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8ZSG0_MYCLB
AccessionPrimary (citable) accession number: B8ZSG0
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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